2022 American Transplant Congress
Study Of Matrix Metalloproteinase (mmp) And Tissue Inhibitors Of Metalloproteinase (timp) Gene Polymorphisms In Renal Allograft Outcome
*Purpose: Our study aimed to find a role, if any, of functional gene polymorphisms of MMP and their inhibitors- TIMP in renal allograft outcome.*Methods: The…2022 American Transplant Congress
Polymorphisms in Ctla-4 Predict De Novo Donor Specific Antibody Formation After Kidney Transplantation
*Purpose: The post-transplant development of donor-specific antibodies (DSAs) initiates the antibody-mediated rejection, which is associated with an increased rate of graft loss. Therefore, risk prediction…2022 American Transplant Congress
Broad Panel Genetic Testing for Chronic Kidney Disease in the Transplant Center
*Purpose: Genetic testing is an emerging tool for the evaluation of patients with end-stage renal disease (ESRD). In kidney transplantation (KT), testing can identify disease…2022 American Transplant Congress
Utility of Genetic Testing in Kidney Transplant Evaluation
*Purpose: Genetic testing is an emerging tool in pre-kidney transplant (KT) evaluations for individuals with end-stage renal disease (ESRD). A known genetic etiology can inform…2022 American Transplant Congress
TNFRSF13B Genotype Determines the Properties of Donor-Specific B Cells
*Purpose: The TNFRSF13B gene is among the 5% most polymorphic genes in humans. The phenotypes of the most frequent TNFRSF13B variants in humans and mice…2022 American Transplant Congress
Use of Ancestral Genetic SNP Phenotyping to Define Genotypic Ethnicity in Solid Organ Transplant Patients
Surgery, Baylor College of Medicine, Houston, TX
*Purpose: Transplantation research has mainly categorized ethnicity into four main groups African American, Caucasian, Hispanic, and Asian Pacific Islander. Our world has increased in admixure…2022 American Transplant Congress
A Pathway for Establishing Etiology of Kidney Failure: An Academic Transplant Center’s Experience with a Broad Kidney Gene Panel
1Loyola University Medical Center, Maywood, IL, 2Natera, Inc., Austin, TX
*Purpose: Assessing genetic causes of kidney failure can inform pre-transplant decision making and may improve post-transplant outcomes. Here we describe an academic transplant center’s experience…2022 American Transplant Congress
Protocolized, Broad-Based Renal Genetic Testing in the Management of Patients at a Transplant Center
*Purpose: Studies show that ~10% of adult chronic kidney diseases (CKD) cases have genetic etiologies. In the nephrology setting, the use of a broad, unbiased…2022 American Transplant Congress
Impact of Cyp 3a5 Genotype on Lcp Tacrolimus Dosing and Monitoring in Kidney Transplantation
Med Univ of South Carolina, Charleston, SC
*Purpose: LCP Tacrolimus has a recommended de novo starting dose of 0.14 mg/kg/day in kidney transplantation (KTR). There is limited data on the influence of…2022 American Transplant Congress
Identification of a Donor Kidney with Heterozygous COL4A3-related Alport Syndrome in a Homozygous Recipient Highlighting the Importance of Genetic Testing
1CLS Health, Webster, TX, 2Natera, Inc., Austin, TX, 3Baylor College of Medicine, Houston, TX
*Purpose: Selection of an appropriate donor for kidney transplantation can mitigate the risk of rejection and increase the chances of graft survival. While immunologic matching…
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