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American Transplant Congress abstracts

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Articles tagged "Gene polymorphism"

  • 2020 American Transplant Congress

    Gasdermin-D Mutation is Protective against Renal Ischemia Reperfusion Injury

    J. Li, N. Rogers, S. Alexander

    Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Westmead, Australia

    *Purpose: Pyroptosis, a pro-inflammatory form of cell death, is dependent on membrane pore formation through the assembly of cleaved Gasdermin-D molecules. We hypothesized that this…
  • 2020 American Transplant Congress

    Combining Pharmacy and Genome-Wide Genotyping Data to Examine Medication Regimen Complexity Indices (MRCI), Drug-Drug and Gene-Drug Interactions in Transplant Patients

    L. Callans, J. Obayemi, H. Gao, A. Shaked, B. Chang, B. Keating

    Penn Transplant Institute, Hospital of the University of Pennsylvania, Philadelphia, USA, Philadelphia, PA

    *Purpose: Polypharmacy, typically defined as the use of five or more medications, is a barrier to adherence, and the resulting complex medication regimens result in…
  • 2020 American Transplant Congress

    Impact of CYP3A5 Phenotype on Early Time in Therapeutic Range among Pediatric Renal and Heart Transplant Recipients

    A. Leino, A. Pasternak

    University of Michigan, Ann Arbor, MI

    *Purpose: Tacrolimus time in therapeutic range (TTR) as a measure of intra-patient variability has been associated with poor long-term outcomes. Multiple factors may contribute to…
  • 2020 American Transplant Congress

    FcγRIIIb Inhibits Renal Transplant Rejection by Inducing Neutrophils Apoptosis

    J. Zhang, J. Chen

    Kidney Disease Center, The First Affiliated Hospital of Zhejiang University, Hangzhou, China

    *Purpose: Fcγ receptors (FcγR) have been proposed to be involved in the pathogenesis of acute rejection (AR) after organ transplantation. However, the mechanisms by which…
  • 2020 American Transplant Congress

    A Single Nucleotide Polymorphism of Tweak Predicts Arterio- and Arteriolohyalinosis in Kidney Transplants and is Associated with Allograft Survival

    A. Karolin1, D. Thottan1, J. Zinsli1, S. Rudloff1, U. Huynh-Do1, V. Banz2, T. Berney3, M. Pascual4, T. Müller5, P. d’Amico6, I. Binet7, D. Sidler1

    1Nephrology and Hypertension, University Bern, Bern, Switzerland, 2University Bern, Bern, Switzerland, 3University Hospital Genevia, Genevia, Switzerland, 4University Hospital Lausanne, Lausanne, Switzerland, 5University Hospital Zurich, Zurich, Switzerland, 6Hospital St.Gallen, St.Gallen, Switzerland, 7University Hospital Basel, Basel, Switzerland

    *Purpose: We have recently demonstrated that the TNF superfamily member is critical for the pathogenesis of Calcineurin Inhibitor Toxicity (CNT). CNT is a common side…
  • 2020 American Transplant Congress

    Impact of Donor Race on Tacrolimus Dose Requirement for Liver Transplant Recipients

    N. Nesselhauf1, S. January1, J. Hagopian1, K. Progar1, A. Khan2

    1Pharmacy, Barnes-Jewish Hospital, St. Louis, MO, 2Surgery, Washington University School of Medicine, St. Louis, MO

    *Purpose: It is well described that there is interpatient variability in tacrolimus dose requirements among transplant recipients. CYP3A5 plays a role in this variability. Black…
  • 2020 American Transplant Congress

    Attempted Validation of Lims1 Variant Rs893403 with Acute Rejection Risk

    W. S. Oetting1, G. Weihua1, C. R. Dorr1, R. B. Mannon2, A. J. Matas1, P. A. Jacobson1, A. K. Israni1

    1University of Minnesota, Minneapolis, MN, 2University of Alabama, Birmingham, AL

    *Purpose: Acute rejection (AR) in kidney allograft recipients is a significant risk factor for reduced graft survival. Identifying individuals at risk for AR could facilitate…
  • 2020 American Transplant Congress

    Pre-Transplant Pharmacogenetics Identifies CYP3A4 and CYP3A5 Heterogeneity among Caucasian Kidney Transplant Recipients

    N. Oliver1, L. Lindberg1, S. LeCorchick1, D. Morris1, S. Anand1, T. Srinivas2

    1Intermountain Medical Center, Murray, UT, 2University Hospitals Cleveland Medical Center, Cleveland, OH

    *Purpose: Tacrolimus has always been dosed based on therapeutic drug monitoring, however pharmacogenomics is becoming increasingly more utilized in the era of precision based medicine…
  • 2020 American Transplant Congress

    Precision Dosing for Tacrolimus Using Genotypes and Clinical Factors

    M. Al-Kofahi1, W. Oetting1, A. Israni2, D. Schladt3, W. Guan4, B. Wu4, C. Dorr5, R. Remmel6, R. Mannon7, N. Pankratz8, A. Matas9, P. Jacobson1

    1Experimental and Clinical Pharmacology, Univ of MN, College of Pharmacy, Minneapolis, MN, 2Nephrology, Univ of MN and Hennepin HealthCare, Minneapolis, MN, 3Hennepin HealthCare Research Institute, Hennepin HealthCare, Minneapolis, MN, 4Biostatistics, Univ of MN, Minneapolis, MN, 5Nephrology, Hennepin HealthCare, Minneapolis, MN, 6Medicinal Chemistry, Univ of MN, College of Pharmacy, Minneapolis, MN, 7Nephrology, Univ of Alabama, Minneapolis, MN, 8Lab Medicine Pathology, Univ of MN, Minneapolis, MN, 9Surgery, Univ of MN, Minneapolis, MN

    *Purpose: Variants in CYP3A4/5 genes, clinical factors and drug-drug interactions are associated with tacrolimus (TAC) clearance and dose. This results in high intra- and inter-…
  • 2019 American Transplant Congress

    CNV Screening For End-stage Renal Disease

    C. E. Fishman, B. Chang, A. Shaked, B. J. Keating

    Surgery, University of Pennsylvania, Philadelphia, PA

    *Purpose: The prevalence of ESRD in the United States was 2,160.7 cases per one million individuals in 2016, and a primary cause of ESRD was…
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