Articles tagged "Gene polymorphism"

2022 American Transplant Congress
Impact of Cyp 3a5 Genotype on Lcp Tacrolimus Dosing and Monitoring in Kidney Transplantation
D. J. Taber, T. Carcella, N. Patel, F. Bartlett, A. Posadas, V. Rao, M. Casey, V. Rohan, D. Dubay, D. Taber
Med Univ of South Carolina, Charleston, SC
*Purpose: LCP Tacrolimus has a recommended de novo starting dose of 0.14 mg/kg/day in kidney transplantation (KTR). There is limited data on the influence of…
2022 American Transplant Congress
Identification of a Donor Kidney with Heterozygous COL4A3-related Alport Syndrome in a Homozygous Recipient Highlighting the Importance of Genetic Testing
K. Alrejjal¹, U. Abdullatif¹, L. Beretich², H. Tabriziani², A. Abdellatif³
¹CLS Health, Webster, TX, ²Natera, Inc., Austin, TX, ³Baylor College of Medicine, Houston, TX
*Purpose: Selection of an appropriate donor for kidney transplantation can mitigate the risk of rejection and increase the chances of graft survival. While immunologic matching…
2022 American Transplant Congress
Significance of Gene Polymorphism on Infectious Complications and Rejection After Liver Transplantation
H. Egawa¹, T. Kato¹, Y. Kotera¹, Y. Hirata¹, S. Yamashita¹, S. Ariizumi¹, T. Ishizuka¹, Y. Tanaka², H. Ohdan³
¹Tokyo Women's Medical University, Tokyo, Japan, ²Surgery, Hiroshima University, Hiroshima, Japan, ³Hiroshima University, Hiroshima, Japan
*Purpose: Clinical application of gene polymorphism is a key of precision medicine in the field of organ transplantation. Hiroshima group reported significance of Fc-gamma receptor…
2022 American Transplant Congress
Recipient MCPggaac Haplotype is Associated with Poor Graft Survival in Recipients with De Novo Thrombotic Microangiopathy
V. Petr¹, D. Csuka², P. Hruba³, Á. Szilágyi², Z. Prohászka², O. Viklicky¹
¹Dept. of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Dept. of Medicine and Hematology, Semmelweis University, Budapest, Hungary, ³Transplant Laboratory, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
*Purpose: De novo thrombotic microangiopathy (TMA) is associated with poor kidney graft survival. We aimed to assess the role of common complement haplotypes in kidney…
2022 American Transplant Congress
Study Of Matrix Metalloproteinase (mmp) And Tissue Inhibitors Of Metalloproteinase (timp) Gene Polymorphisms In Renal Allograft Outcome
J. P. Tom¹, J. Singh¹, A. Sharma², R. Aggarwal¹, R. Nada³, R. Ramachandran⁴, S. Anand¹, R. Minz¹
¹Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, ²Department of Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India, ³Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, ⁴Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
*Purpose: Our study aimed to find a role, if any, of functional gene polymorphisms of MMP and their inhibitors- TIMP in renal allograft outcome.*Methods: The…
2022 American Transplant Congress
Polymorphisms in Ctla-4 Predict De Novo Donor Specific Antibody Formation After Kidney Transplantation
K. Ono, K. Ide, H. Yamane, S. Akimoto, N. Tanimine, H. Tahara, M. Ohira, Y. Tanaka, H. Ohdan
Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health S, Hiroshima University, Hiroshima City, Japan
*Purpose: The post-transplant development of donor-specific antibodies (DSAs) initiates the antibody-mediated rejection, which is associated with an increased rate of graft loss. Therefore, risk prediction…
2022 American Transplant Congress
Broad Panel Genetic Testing for Chronic Kidney Disease in the Transplant Center
A. Bhalla¹, D. Raible², V. Balaraman¹, M. Talwar¹
¹James D. Eason Transplant Institute, Methodist University Hospital, Memphis, TN, ²Natera, Inc., Austin, TX
*Purpose: Genetic testing is an emerging tool for ‌the evaluation of patients with end-stage renal disease (ESRD). In kidney transplantation (KT), testing can identify disease…
2022 American Transplant Congress
Utility of Genetic Testing in Kidney Transplant Evaluation
N. Singh¹, A. Palermini², A. Qamar¹, M. S. Naseer¹, H. Shokouh-Amiri¹, G. Zibari¹, D. Aultman¹, L. Beretich³, D. Luksic³, J. Gibson³, S. McCormick³, H. Tabriziani³, P. Billings³
¹Willis Knighton Physician's Network, John C. McDonald Regional Transplant Center, Shreveport, LA, ²Arkansas College of Osteopathic Medicine, Fort Smith, AR, ³Natera, Inc., Austin, TX
*Purpose: Genetic testing is an emerging tool in pre-kidney transplant (KT) evaluations for individuals with end-stage renal disease (ESRD). A known genetic etiology can inform…
2022 American Transplant Congress
TNFRSF13B Genotype Determines the Properties of Donor-Specific B Cells
M. Cascalho¹, M. Garcia de Mattos Barbosa¹, T. Pasieka¹, E. Farkash², R. Sung³, M. Doshi⁴, J. Platt⁴
¹Surgery, University of Michigan, Ann Arbor, MI, ²Pathology, University of Michigan, Ann Arbor, MI, ³University of Michigan Health System, Ann Arbor, MI, ⁴University of Michigan, Ann Arbor, MI
*Purpose: The TNFRSF13B gene is among the 5% most polymorphic genes in humans. The phenotypes of the most frequent TNFRSF13B variants in humans and mice…
2022 American Transplant Congress
Use of Ancestral Genetic SNP Phenotyping to Define Genotypic Ethnicity in Solid Organ Transplant Patients
P. Jindra, T. Tu, N. D'Silva, C. T. Stewart, J. Magana, N. Chitnis
Surgery, Baylor College of Medicine, Houston, TX
*Purpose: Transplantation research has mainly categorized ethnicity into four main groups African American, Caucasian, Hispanic, and Asian Pacific Islander. Our world has increased in admixure…

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