Articles tagged "Endothelial cells"

2021 American Transplant Congress
Single-Cell RNA-seq Identifies Intra-Graft Population Heterogeneity in Acute Heart Allograft Rejection in the Mouse
C. Wu¹, Y. Tang¹, X. Shi¹, X. He¹, X. Li²
¹The First Affiliated Hospital,Sun Yat-sen University, Guangzhou, China, ²Immunobiology & Transplant Sciences Houston Methodist Hospital, Houston, TX
*Purpose: Transplant rejection remains a major barrier to graft survival and involves a diversity of cell types. But the heterogeneity in a given cell type…
2021 American Transplant Congress
Extracellular Matrix Injury of Kidney Allografts in Antibody-mediated Rejection
S. Clotet Freixas¹, C. McEvoy¹, I. Batruch², C. Pastrello³, M. Kotlyar³, J. Van¹, M. Arambewela¹, A. Boshart¹, S. Farkona¹, Y. Niu³, Y. Li¹, O. Famure¹, A. Bozovic⁴, V. Kulasingam⁴, P. Chen¹, J. S. Kim¹, E. Chan⁵, S. Moshkelgosha¹, S. A. Rahman⁶, J. Das⁶, T. Martinu¹, S. Juvet¹, I. Jurisica³, A. Chruscinski¹, R. John¹, A. Konvalinka¹
¹Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, ²Department of Laboratory Medicine and Pathobiology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, ³Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁴Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, ⁵Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada, ⁶Center for Systems Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: Antibody-mediated rejection (AMR) accounts for >50% of kidney graft losses. AMR is caused by donor-specific antibodies (DSA) against HLA and non-HLA antigens in glomeruli…
2021 American Transplant Congress
Digital Spatial Mrna Profiling Reveals Distinct Endothelial Transcripts in Dsa+ and Dsa- Endarteritis in Kidney Allografts
K. Tomaszewski¹, M. Araujo Medina¹, A. Bruce¹, P. Divakar², R. Smith¹, T. Kawai³, R. Colvin¹, I. Rosales¹
¹Department of Pathology, Massachusetts General Hospital, Boston, MA, ²NanoString Technologies, Inc., Seattle, WA, ³Department of Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Renal allograft biopsy transcript analysis is typically performed by microarray, which lacks spatial resolution. We initiated a systematic program using the NanoString GeoMx® Digital…
2021 American Transplant Congress
Lymphotoxin Beta Receptor Regulates Treg Migration and Suppression by Modulating Draining Lymphatic Structure
V. Saxena¹, W. Piao¹, L. Li¹, M. W. Shirkey¹, J. Iyyathurai¹, R. Lakhan¹, R. Abdi², J. Bromberg¹
¹U Maryland, Baltimore, MD, ²Harvard U, Boston, MA
*Purpose: Regulatory T cells (Treg) must migrate from tissues via lymphatic vessels (LV) to the draining lymph node (dLN) to induce tolerance. During migration, Treg…
2021 American Transplant Congress
Versatile Strategy to Enhance Nanomedicine Delivery to Graft Endothelial Cells
C. Albert¹, L. G. Bracaglia¹, A. Koide², J. DiRito¹, T. Lysyy¹, C. Edwards¹, J. T. Langford¹, D. Haakinson¹, S. A. Hosgood³, M. L. Nicholson³, J. S. Pober¹, W. M. Saltzman¹, S. Kiode², G. Tietjen¹
¹Yale University, new haven, CT, ²Perlmutter Cancer Center, New York University, Langone Medical Center, New York, NY, ³University of Cambridge, Cambridge, United Kingdom
*Purpose: Efficient delivery of therapeutics to graft endothelial cells (EC) can potentially render organs more resistant to injury, improving clinical outcomes. Specific targeting of polymeric…
2021 American Transplant Congress
Src Kinase Inhibitor Pp1 Blunts Tgf-β1 Dependent Endothelial‐to‐Mesenchymal Transition to Alleviate Allograft Kidney Fibrosis Through Orchestrating β-catenin Signaling
Z. Gui, Z. Wang, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu
Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Allograft fibrosis is an important contributor to graft loss in chronic renal allograft injury. Endothelial‐to‐mesenchymal transition (EndMT), dysfunction of endothelial cells, played a vital…
2021 American Transplant Congress
Extracellular Vesicles from Patients with Diabetic Nephropathy Induce Endothelial Dysfunction Through Icam-1 and Vcam-1 in an In Vitro Model
E. Montagud-Marrahi¹, S. Torramadé-Moix², M. Ramirez-Bajo³, J. Rovira³, E. Bañón-Maneus³, E. Hermida¹, F. Diekmann¹, M. Palomo⁴, M. Díaz-Ricart², P. Ventura-Aguiar¹
¹Nephrology and Kidney Transplantation Department, Hospital Clínic de Barcelona, Barcelona, Spain, ²Hematopathology Department, Hospital Clínic de Barcelona, Barcelona, Spain, ³Nephrology and Transplant Experimental Laboratory (LENIT), Hospital Clínic de Barcelona, Barcelona, Spain, ⁴Josep Carreras Leukaemia Research Institute, Hospital Clínic de Barcelona, Barcelona, Spain
*Purpose: Extracellular Vesicles (EVs) are membranous structures produced by cells which contain different cytoplasmic compounds and that have been described as potentially pathogenic elements in…
2021 American Transplant Congress
HLA I Antibody-Activated Endothelium Polarized M2-Like Macrophages with Increased Efferocytic and Phagocytic Capacity
J. Nevarez-Mejia¹, X. Wei¹, N. M. Valenzuela¹, M. Rossetti¹, H. Pickering¹, G. A. Fishbein¹, A. Mulder², E. F. Reed¹
¹Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, ²Immunohematology and Blood Transfusion, LUMC, Leiden, Netherlands
*Purpose: The role of intragraft macrophages (Mϕs) during antibody-mediated rejection (AMR) remains unclear. Anti-HLA Abs during AMR drives vascular inflammation as seen by monocyte recruitment…
2020 American Transplant Congress
The Role of Galectin-1 and Basement Membrane Remodeling in Kidney Antibody-Mediated Rejection
S. Clotet-Freixas¹, C. McEvoy¹, I. Batruch², M. Kotlyar³, C. Pastrello³, J. Van¹, M. Arambewela¹, A. Boshart¹, S. Farkona¹, A. Bozovic⁴, V. Kulasingam⁴, P. Chen¹, I. Jurisica³, A. Chruscinski¹, R. John⁴, A. Konvalinka⁵
¹Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, ²Department of Laboratory Medicine and Pathobiology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, ³Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁴Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, ⁵Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada
*Purpose: Antibody-mediated rejection (AMR), the leading cause of kidney graft loss, is caused by anti-HLA and non-HLA antibodies against proteins in two main kidney compartments:…
2020 American Transplant Congress
Treg Protection of the Allograft Depends on Lymphotoxin Beta Receptor Expression in Lymphatic Endothelial Cells
V. Saxena¹, W. Piao¹, L. Li¹, Y. Xiong¹, C. Palusckievicz¹, T. Simon¹, M. Shirkey¹, R. Abdi², J. S. Bromberg¹
¹University of Maryland, Baltimore, Baltimore, MD, ²Harvard U, Boston, MA
*Purpose: Regulatory T cell (Treg) migration to afferent lymphatics and lymph nodes (LN), and suppressive function, require Treg lymphotoxin alpha (LTα) to stimulate LT beta-receptor…

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