ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Endothelial cells"

  • 2022 American Transplant Congress

    Pd-1 Licenses Activated Treg for Lymphatic Migration

    W. Piao1, L. Li1, V. Saxena1, K. Hippen2, M. Shirkey1, B. Blazar2, I. Lape3, y. zhang3, J. Bromberg1

    1Surgery, University of Maryland, Baltimore, MD, 2University of Minnesota, Minneapolis, MN, 3Harvard Medical School, Boston, MA

    *Purpose: In addition to serving as fluid conduits, lymphatic vessels are critical portals for immune cell migration. Lymphatic endothelial cells (LECs) constitutively express high levels…
  • 2022 American Transplant Congress

    Treg Migration and Suppression Require Engagement with Lymphotoxin Beta Receptor on Lymphatic Endothelial Cells to Protect Islet Allografts

    V. Saxena1, W. Piao1, L. Li1, M. WillsonShirkey1, R. Lakhan1, S. Walden2, K. L. Hippen2, B. R. Blazar2, J. S. Bromberg1

    1University of Maryland School of Medicine, Baltimore, MD, 2University of Minnesota, Minneapolis, MN

    *Purpose: Treg sequential migration from graft to draining lymph nodes (dLN) via afferent lymphatics is required for Treg suppressive function. Treg lymphotoxin alpha beta (LTαβ)…
  • 2022 American Transplant Congress

    Polarized Il-6 Secretion from Lymphatic Endothelial Cells Promotes Treg Conversion to Extregs

    V. Saxena1, W. Piao1, L. Li1, M. W. Shirkey1, R. Lakhan1, S. Walden2, K. L. Hippen2, B. Blazar2, J. S. Bromberg1

    1University of Maryland School of Medicine, Baltimore, MD, 2University of Minnesota, Minneapolis, MN

    *Purpose: Regulatory T cell (Treg) suppressor function and allograft protection depend on maintenance of transcription factor Foxp3 expression and lymphatic migration. Lymphatic endothelial cell (LEC)…
  • 2022 American Transplant Congress

    Cd80 on Effector T Cell Binds Pd-l1 on Lymphatic Endothelial Cells to Fine Tune Migration

    W. Piao1, V. Saxena1, L. Li1, K. Hippen2, Y. Zhang2, B. Blazar2, I. Lape3, L. Riella3, J. Bromberg1

    1Surgery, University of Maryland, Baltimore, MD, 2University of Minnesota, Minneapolis, MN, 3Harvard Medical School, Boston, MA

    *Purpose: Antigen presenting cell (APC) CD80 trans-binds CD28 and CTLA4 on T cells, boosting or inhibiting immunity, respectively. CD80 has another ligand, Programmed Death-1 Ligand…
  • 2022 American Transplant Congress

    Sting but Not Mtor Signaling Regulates Exogenous Mitochondrion-Induced Endothelial Cell Mitophagy

    H. Xu, L. Wang, A. D. Kirk, H. Xu

    Duke University School of Medicine, Durham, NC

    *Purpose: We have previously demonstrated activation and increasing mitophagy of human endothelial cells (ECs) following exogenous mitochondrion-stimulation. The objectives of this study were to evaluate…
  • 2022 American Transplant Congress

    Bcl6b is a Putative Regulator of Endothelial Identity and Endmt

    N. M. Valenzuela

    Pathology and Laboratory Medicine, UCLA, Los Angeles, CA

    *Purpose: Loss of endothelial cell (EC) identity is central to endothelial to mesenchymal transition (EndMT) implicated in neointimal hyperplasia in transplant vasculopathy. However, the molecular…
  • 2022 American Transplant Congress

    HLA-II Subclasses Behave Differently Between Themselves and Between Humans: Cues to Understand Alloreactivity

    S. Beland, O. Desy, M. Marcoux, M. Thivierge, J. Desgagnes, S. A. De Serres

    Transplantation Unit, Renal Division, University Health Center of Quebec, Faculty of Medicine, Universite Laval, Quebec, QC, Canada

    *Purpose: De novo anti-HLA-II DSAs (dnDSA) are associated with antibody-mediated rejection. However, some patients with anti-HLA-II DSAs will not develop rejection, suggesting that the development…
  • 2022 American Transplant Congress

    HDAC Inhibitors Suppress Endothelial Inflammation but Alter Identity

    N. M. Valenzuela

    Pathology and Laboratory Medicine, UCLA, Los Angeles, CA

    *Purpose: Histone modifications such as acetylation control gene expression. Histone deacetylases (HDACs) have been proposed as an attractive therapeutic approach to counteract detrimental gene expression,…
  • 2022 American Transplant Congress

    Functional Recellularized Patient Derived Endothelium; A Human Vascular Graft Approach

    H. Tejeda Mora1, J. Willemse2, Y. den Hartog1, I. Schurink2, M. M. Verstegen2, J. de Jonge2, R. C. Minnee2, M. W. van den Hoogen2, C. C. Baan1, L. J. van der Laan2, M. J. Hoogduijn1

    1Transplant Institute - Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands, 2Transplant Institute - Department of Surgery, Erasmus Medical Center, Rotterdam, Netherlands

    *Purpose: In transplantation, the endothelial lining is the first barrier between the donor organ and recipient immune system. Damaged endothelium exposes extracellular matrix (ECM) molecules…
  • 2022 American Transplant Congress

    Stabilization of Cell-Cell Junctions Improves Outcomes in an Ex-Vivo Porcine Renal Ischemia-Reperfusion Injury Culture Model

    L. Plumblee1, K. Patel2, L. Langerude3, Z. Tu3, D. Nord4, T. Beduschi3, S. Nadig5, C. Atkinson6

    1MUSC College of Medicine, Gainesville, FL, 2University of Virgina, Charlottesville, VA, 3University of Florida, Gaineville, FL, 4Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida, Gainesville, FL, 5Northwestern University, Charleston, SC, 6Pulmonary Medicine, University of Florida, Gainesville, FL

    *Purpose: Renal transplant is an accepted therapy for end-stage renal failure. Chronic transplant dysfunction remains the leading cause of long-term graft loss and is, in…
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