ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Endothelial cells"

  • 2020 American Transplant Congress

    The Role of Galectin-1 and Basement Membrane Remodeling in Kidney Antibody-Mediated Rejection

    S. Clotet-Freixas1, C. McEvoy1, I. Batruch2, M. Kotlyar3, C. Pastrello3, J. Van1, M. Arambewela1, A. Boshart1, S. Farkona1, A. Bozovic4, V. Kulasingam4, P. Chen1, I. Jurisica3, A. Chruscinski1, R. John4, A. Konvalinka5

    1Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 2Department of Laboratory Medicine and Pathobiology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, 3Krembil Research Institute, University Health Network, Toronto, ON, Canada, 4Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, 5Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada

    *Purpose: Antibody-mediated rejection (AMR), the leading cause of kidney graft loss, is caused by anti-HLA and non-HLA antibodies against proteins in two main kidney compartments:…
  • 2020 American Transplant Congress

    Treg Protection of the Allograft Depends on Lymphotoxin Beta Receptor Expression in Lymphatic Endothelial Cells

    V. Saxena1, W. Piao1, L. Li1, Y. Xiong1, C. Palusckievicz1, T. Simon1, M. Shirkey1, R. Abdi2, J. S. Bromberg1

    1University of Maryland, Baltimore, Baltimore, MD, 2Harvard U, Boston, MA

    *Purpose: Regulatory T cell (Treg) migration to afferent lymphatics and lymph nodes (LN), and suppressive function, require Treg lymphotoxin alpha (LTα) to stimulate LT beta-receptor…
  • 2020 American Transplant Congress

    Single Cell Analysis Reveals Endothelial Activation of Interleukin-6 Mediated Signaling Pathway in Microvascular Inflammation with and without c4d

    A. S. Naik1, R. Menon1, E. Farkash1, E. Otto1, C. C. Berthier1, S. Norman1, M. Samaniego2, M. Kretzler1

    1University of Michigan, Ann Arbor, MI, 2Henry Ford Hospital, Detroit, MI

    *Purpose: Microvascular inflammation (MVI) is a feature of antibody mediated rejection. MVI can be seen with or without activation of other effectors of antibody injury…
  • 2020 American Transplant Congress

    Cyclophilin-D Inhibition Mitigates Cardiac Allograft Ischemia-Reperfusion Injury and Rejection

    A. Qamar1, P. McLeod2, J. Jiang2, X. Huang2, A. M. Jevnikar2, Z. Zhang2

    1Pathology & Laboratory Medicine, University of Western Ontario, London, ON, Canada, 2London Health Sciences Center, London, ON, Canada

    *Purpose: The clinical relevance of ischemia-reperfusion injury (IRI) in the context of organ transplantation is well-established. IRI is associated with various forms of programmed cell…
  • 2020 American Transplant Congress

    Bone Marrow Mesenchymal Stem Cells Improve Rat Islet Angiogenesis by Upregulating of ISL1 and VEGF-A

    Y. Wang1, J. Wang2, X. Ding2

    1Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China, 2Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

    *Purpose: Islet transplantation is an important therapy to cure diabetes, but poor angiogenesis in the early stage of islet transplantation is one of the main…
  • 2020 American Transplant Congress

    Inflammatory Cytokines Have a Different Effect from One HLA-II Subclass to Another on Human Endothelium

    S. Beland, F. Bouchard-Boivin, A. Gama, O. Desy, S. A. De Serres

    Universite Laval, Quebec, QC, Canada

    *Purpose: Development of de novo donor-specific antibodies (DSAs) is associated with antibody-mediated rejection and allograft failure. More particularly, HLA-II DSAs, especially those against DQ are…
  • 2020 American Transplant Congress

    Novel Technique to Analyze Blood-Endothelial Cell Interactions Under Flow Conditions

    M. R. Connolly1, K. Petitpas1, L. Burdorf1, B. Cerel1, C. Laird2, D. Harris2, A. Azimzadeh1, R. N. Pierson III1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2University of Maryland, Baltimore, Baltimore, MD

    *Purpose: The Bioflux system has been used to study platelet-driven thrombosis and leukocyte adhesion. Typically, whole blood is stained with calcein (green) to evaluate platelet…
  • 2020 American Transplant Congress

    Autophagy Attenuates Renal Allograft Interstitial Fibrosis by Regulating the EndMT Induced by TNF-α

    Z. Gui, C. Suo, Z. Wang, S. Fei, Z. Han, J. Tao, H. Chen, L. Sun, X. Ju, R. Tan, M. Gu

    Jiangsu Province Hospital, Nanjing, China

    *Purpose: Kidney interstitial fibrosis is a significant cause of allograft failure in kidney transplantation. Autophagy is a self-digestive process that eliminates impaired or aged proteins…
  • 2020 American Transplant Congress

    Src Induces Endothelial-to-Mesenchymal Transition and Renal Allograft Fibrosis via Promoting WNT/β-catenin Pathway

    W. Zijie, Z. Gui, M. Zheng, Z. Han, J. Tao, H. Chen, L. Sun, X. Ju, R. Tan, M. Gu

    Jiangsu Province Hospital, Nanjing, China

    *Purpose: Endothelial-to-mesenchymal(EndMT)is recognized as an important source of myofibroblasts contributing to the pathogenesis of allograft interstitial fibrosis in our previous studies. Increased proto-oncogene tyrosine-protein kinase…
  • 2020 American Transplant Congress

    Treg-Lymphatic Interfaces: Unique Molecular Structures for Cell-Cell Interactions During Migration

    C. M. Paluskievicz, W. Piao, Y. Xiong, J. S. Bromberg

    U of Maryland, Baltimore, MD

    *Purpose: To promote transplant tolerance, T regulatory cells (Treg) must enter the afferent lymphatic vasculature by migrating across lymphatic endothelial cells (LECs), and then home…
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