ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Endothelial cells"

  • 2022 American Transplant Congress

    Bcl6b is a Putative Regulator of Endothelial Identity and Endmt

    N. M. Valenzuela

    Pathology and Laboratory Medicine, UCLA, Los Angeles, CA

    *Purpose: Loss of endothelial cell (EC) identity is central to endothelial to mesenchymal transition (EndMT) implicated in neointimal hyperplasia in transplant vasculopathy. However, the molecular…
  • 2022 American Transplant Congress

    HLA-II Subclasses Behave Differently Between Themselves and Between Humans: Cues to Understand Alloreactivity

    S. Beland, O. Desy, M. Marcoux, M. Thivierge, J. Desgagnes, S. A. De Serres

    Transplantation Unit, Renal Division, University Health Center of Quebec, Faculty of Medicine, Universite Laval, Quebec, QC, Canada

    *Purpose: De novo anti-HLA-II DSAs (dnDSA) are associated with antibody-mediated rejection. However, some patients with anti-HLA-II DSAs will not develop rejection, suggesting that the development…
  • 2022 American Transplant Congress

    HDAC Inhibitors Suppress Endothelial Inflammation but Alter Identity

    N. M. Valenzuela

    Pathology and Laboratory Medicine, UCLA, Los Angeles, CA

    *Purpose: Histone modifications such as acetylation control gene expression. Histone deacetylases (HDACs) have been proposed as an attractive therapeutic approach to counteract detrimental gene expression,…
  • 2022 American Transplant Congress

    Functional Recellularized Patient Derived Endothelium; A Human Vascular Graft Approach

    H. Tejeda Mora1, J. Willemse2, Y. den Hartog1, I. Schurink2, M. M. Verstegen2, J. de Jonge2, R. C. Minnee2, M. W. van den Hoogen2, C. C. Baan1, L. J. van der Laan2, M. J. Hoogduijn1

    1Transplant Institute - Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands, 2Transplant Institute - Department of Surgery, Erasmus Medical Center, Rotterdam, Netherlands

    *Purpose: In transplantation, the endothelial lining is the first barrier between the donor organ and recipient immune system. Damaged endothelium exposes extracellular matrix (ECM) molecules…
  • 2022 American Transplant Congress

    Stabilization of Cell-Cell Junctions Improves Outcomes in an Ex-Vivo Porcine Renal Ischemia-Reperfusion Injury Culture Model

    L. Plumblee1, K. Patel2, L. Langerude3, Z. Tu3, D. Nord4, T. Beduschi3, S. Nadig5, C. Atkinson6

    1MUSC College of Medicine, Gainesville, FL, 2University of Virgina, Charlottesville, VA, 3University of Florida, Gaineville, FL, 4Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida, Gainesville, FL, 5Northwestern University, Charleston, SC, 6Pulmonary Medicine, University of Florida, Gainesville, FL

    *Purpose: Renal transplant is an accepted therapy for end-stage renal failure. Chronic transplant dysfunction remains the leading cause of long-term graft loss and is, in…
  • 2022 American Transplant Congress

    Selective Vascular Decellularization and Endothelial Cells Replacement as a Strategy to Reduce Reperfusion Injury in Bioartificial Organs

    G. Haeublein1, G. Lombardi1, F. Caro1, R. Carla1, D. Guerrieri1, C. Incardona2, D. Casadei3, E. Chuluyan1

    1CEFYBO, Buenos Aires, Argentina, 2GADOR S.A., Buenos Aires, Argentina, 3Fundación Argentina de Trasplante, Tercer Milenio, Buenos Aires, Argentina

    *Purpose: The number of kidney transplants performed each year cannot meet the increasing demand of these organs. Several strategies aim to increasing the offer of…
  • 2022 American Transplant Congress

    Enhanced Delivery of Nanomedicine to Human Kidney During Ex Vivo Perfusion

    C. Albert1, L. Bracaglia1, A. Koide2, J. R. DiRito1, T. Lysyy1, E. Christopher1, J. Grundler1, J. T. Langford1, D. Haakinson1, J. S. Pober1, W. M. Saltzman1, S. Koide2, G. Tietjen1

    1Yale University, new haven, CT, 2Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY

    *Purpose: An efficient delivery of therapeutic agents to graft endothelial cells (ECs) prior to transplantation could render organs more resistant to injury, improving clinical outcomes…
  • 2022 American Transplant Congress

    Towards Bionic Organs: Biocompatibility Of Newly Developed Porcine Decm-based Hydrogels.

    M. Rachalewski, M. Klak, D. Ujazdowska, P. Cywoniuk, T. Dobrzanski, G. Tymicki, K. Kosowska, T. Bryniarski, A. Berman, M. Wszola

    Foundation of Research and Science Development, Warsaw, Poland

    *Purpose: There is a growing interest in fabrication of bioinks which on one hand biocompatible and on the other hand possess mechanical properties which would…
  • 2022 American Transplant Congress

    Treg Tissue Stability Depends on Adenosine Receptor Driven Lymphatic Endothelial Cell Responses

    V. Saxena1, W. Piao1, L. Li1, M. W. Shirkey1, R. Lakhan1, S. Walden2, K. L. Hippen2, B. R. Blazar2, J. S. Bromberg1

    1University of Maryland School of Medicine, Baltimore, MD, 2University of Minnesota, Minneapolis, MN

    *Purpose: Regulatory T cell (Treg) lymphatic migration and maintenance of transcription factor Foxp3 expression are required for suppressor function and allograft protection. Migrating Tregs were…
  • 2022 American Transplant Congress

    LGALS1 is Expressed in Glomerular Endothelial Cells and Induced Upon Stimulation with Anti-HLA Antibody

    A. Boshart1, S. Farkona1, S. Clotet-Freixas1, C. McEvoy1, J. Murphy1, S. Crome2, A. Konvalinka3

    1Toronto General Hospital Research Institute, Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada, 2Immunology, Toronto General Hospital Research Institute, Ajmera Transplant Centre, University of Toronto, University Health Network, Toronto, ON, Canada, 3Nephrology, Toronto General Hospital Research Institute, Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada

    *Purpose: Antibody-mediated rejection (AMR) accounts for >50% of premature kidney graft loss. AMR is caused by donor specific antibodies (DSA) against human leukocyte antigens (HLA)…
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