ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Endothelial cells"

  • 2021 American Transplant Congress

    PD-1/PD-L1 Selectively Regulates Treg Lymphatic Migration

    W. Piao1, L. Li1, C. Paluskievicz1, Y. Zhang2, V. Saxena3, K. Hippen2, B. Blazar2, L. Riella4, J. Bromberg1

    1Surgery, U Maryland, Baltimore, MD, 2U Minnesota, Minneapolis, MN, 3U Maryland, Baltimore, MD, 4Harvard U, Boston, MA

    *Purpose: The molecules that regulate Treg migration are incompletely identified. Programmed death-1 (PD-1) and its ligand PD-L1 are immune checkpoint proteins which regulate immune cell…
  • 2021 American Transplant Congress

    LTβR Engagement Regulates Treg Migration, Stability and Suppressor Function

    V. Saxena1, W. Piao1, L. Li1, Y. Xiong1, M. W. Shirkey1, J. Iyyathurai1, R. Lakhan1, R. Abdi2, J. Bromberg1

    1U Maryland, Baltimore, MD, 2Harvard U, Boston, MA

    *Purpose: Regulatory T cell (Treg) lymphatic migration and maintenance of transcription factor Foxp3 expression are required for suppressor function and allograft protection. Treg stimulate lymphotoxin…
  • 2021 American Transplant Congress

    Atg16l-Dependent Autophagy Attenuates Procession of Renal Interstitial Fibrosis in Chronic Renal Graft Dysfunction via Regulating Tumor Necrosis Factor Alpha (tnf-α) Induced Endmt

    Z. Gui, Z. Wang, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu

    The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: Chronic renal graft dysfunction is characterized by inflammation, tubular injury, and interstitial fibrosis. We have confirmed that endothelial-mesenchymal transition (EndMT) was one of important…
  • 2021 American Transplant Congress

    Single-Cell RNA-seq Identifies Intra-Graft Population Heterogeneity in Acute Heart Allograft Rejection in the Mouse

    C. Wu1, Y. Tang1, X. Shi1, X. He1, X. Li2

    1The First Affiliated Hospital,Sun Yat-sen University, Guangzhou, China, 2Immunobiology & Transplant Sciences Houston Methodist Hospital, Houston, TX

    *Purpose: Transplant rejection remains a major barrier to graft survival and involves a diversity of cell types. But the heterogeneity in a given cell type…
  • 2021 American Transplant Congress

    Extracellular Matrix Injury of Kidney Allografts in Antibody-mediated Rejection

    S. Clotet Freixas1, C. McEvoy1, I. Batruch2, C. Pastrello3, M. Kotlyar3, J. Van1, M. Arambewela1, A. Boshart1, S. Farkona1, Y. Niu3, Y. Li1, O. Famure1, A. Bozovic4, V. Kulasingam4, P. Chen1, J. S. Kim1, E. Chan5, S. Moshkelgosha1, S. A. Rahman6, J. Das6, T. Martinu1, S. Juvet1, I. Jurisica3, A. Chruscinski1, R. John1, A. Konvalinka1

    1Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 2Department of Laboratory Medicine and Pathobiology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, 3Krembil Research Institute, University Health Network, Toronto, ON, Canada, 4Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, 5Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada, 6Center for Systems Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA

    *Purpose: Antibody-mediated rejection (AMR) accounts for >50% of kidney graft losses. AMR is caused by donor-specific antibodies (DSA) against HLA and non-HLA antigens in glomeruli…
  • 2021 American Transplant Congress

    Digital Spatial Mrna Profiling Reveals Distinct Endothelial Transcripts in Dsa+ and Dsa- Endarteritis in Kidney Allografts

    K. Tomaszewski1, M. Araujo Medina1, A. Bruce1, P. Divakar2, R. Smith1, T. Kawai3, R. Colvin1, I. Rosales1

    1Department of Pathology, Massachusetts General Hospital, Boston, MA, 2NanoString Technologies, Inc., Seattle, WA, 3Department of Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: Renal allograft biopsy transcript analysis is typically performed by microarray, which lacks spatial resolution. We initiated a systematic program using the NanoString GeoMx® Digital…
  • 2021 American Transplant Congress

    Lymphotoxin Beta Receptor Regulates Treg Migration and Suppression by Modulating Draining Lymphatic Structure

    V. Saxena1, W. Piao1, L. Li1, M. W. Shirkey1, J. Iyyathurai1, R. Lakhan1, R. Abdi2, J. Bromberg1

    1U Maryland, Baltimore, MD, 2Harvard U, Boston, MA

    *Purpose: Regulatory T cells (Treg) must migrate from tissues via lymphatic vessels (LV) to the draining lymph node (dLN) to induce tolerance. During migration, Treg…
  • 2021 American Transplant Congress

    Versatile Strategy to Enhance Nanomedicine Delivery to Graft Endothelial Cells

    C. Albert1, L. G. Bracaglia1, A. Koide2, J. DiRito1, T. Lysyy1, C. Edwards1, J. T. Langford1, D. Haakinson1, S. A. Hosgood3, M. L. Nicholson3, J. S. Pober1, W. M. Saltzman1, S. Kiode2, G. Tietjen1

    1Yale University, new haven, CT, 2Perlmutter Cancer Center, New York University, Langone Medical Center, New York, NY, 3University of Cambridge, Cambridge, United Kingdom

    *Purpose: Efficient delivery of therapeutics to graft endothelial cells (EC) can potentially render organs more resistant to injury, improving clinical outcomes. Specific targeting of polymeric…
  • 2021 American Transplant Congress

    Src Kinase Inhibitor Pp1 Blunts Tgf-β1 Dependent Endothelial‐to‐Mesenchymal Transition to Alleviate Allograft Kidney Fibrosis Through Orchestrating β-catenin Signaling

    Z. Gui, Z. Wang, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu

    Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: Allograft fibrosis is an important contributor to graft loss in chronic renal allograft injury. Endothelial‐to‐mesenchymal transition (EndMT), dysfunction of endothelial cells, played a vital…
  • 2021 American Transplant Congress

    Extracellular Vesicles from Patients with Diabetic Nephropathy Induce Endothelial Dysfunction Through Icam-1 and Vcam-1 in an In Vitro Model

    E. Montagud-Marrahi1, S. Torramadé-Moix2, M. Ramirez-Bajo3, J. Rovira3, E. Bañón-Maneus3, E. Hermida1, F. Diekmann1, M. Palomo4, M. Díaz-Ricart2, P. Ventura-Aguiar1

    1Nephrology and Kidney Transplantation Department, Hospital Clínic de Barcelona, Barcelona, Spain, 2Hematopathology Department, Hospital Clínic de Barcelona, Barcelona, Spain, 3Nephrology and Transplant Experimental Laboratory (LENIT), Hospital Clínic de Barcelona, Barcelona, Spain, 4Josep Carreras Leukaemia Research Institute, Hospital Clínic de Barcelona, Barcelona, Spain

    *Purpose: Extracellular Vesicles (EVs) are membranous structures produced by cells which contain different cytoplasmic compounds and that have been described as potentially pathogenic elements in…
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