2022 American Transplant Congress
Zfyve21 Activates T Cell Intrinsic, Nlrp3 Inflammasomes to Promote Allograft Vasculopathy
*Purpose: Allograft vasculopathy (AV) is a complication of chronic allograft rejection whose underlying mechanism(s) of etiopathogenesis are poorly defined. We examined the role of ZFYVE21,…2022 American Transplant Congress
Fibrinolysis Shutdown Subtype of Early Allograft Dysfunction Represents the Predominant Cohort of Patients with Graft Failure Following Liver Transplantation
*Purpose: Early allograft dysfunction (EAD) is associated with an increased rate of graft failure in liver transplantation (LT), but a mechanism remains unclear. Recent experience…2022 American Transplant Congress
Overexpression of Human Ectonucleoside Triphosphate Diphosphohydrolase 1 (entpd1; Hcd39) Did Not Afford Significant Protection on Porcine Endothelial Cells
*Purpose: The thromboregulatory and anti-inflammatory potential of human CD39 (hCD39) makes it a gene of interest in xenotransplantation. In porcine endothelium, CD39 activity is generally…2022 American Transplant Congress
Selective Vascular Decellularization and Endothelial Cells Replacement as a Strategy to Reduce Reperfusion Injury in Bioartificial Organs
*Purpose: The number of kidney transplants performed each year cannot meet the increasing demand of these organs. Several strategies aim to increasing the offer of…2022 American Transplant Congress
Novel Phenotype of Intragraft Endothelial Cells That Modulates CD4+ T Effector-Mediated Rejection
Boston Children's Hospital, Boston, MA
*Purpose: Previous studies have suggested that early adoptive transfer of Teff into Rag KO mice bearing cardiac transplants results in acute rejection. However, if transfer…2022 American Transplant Congress
Bcl6 Regulates NFκB-Controlled Endothelial Inflammation and Apoptosis
Pathology and Laboratory Medicine, UCLA, Los Angeles, CA
*Purpose: Endothelial cells (EC) centrally regulate leukocyte access to peripheral tissue and immune cell activation, and exhibit remarkable tissue-specific diversity. However, the molecular mechanisms underlying…2021 American Transplant Congress
A Molecular Classifier Identifies Antibody-Mediated Rejection-Associated Changes in Lung Transplant Biopsies
*Purpose: Identifying lung transplant antibody-mediated rejection (ABMR) has been controversial. We compared gene expression in donor-specific antibody (DSA) positive vs. DSA negative lung transbronchial biopsies…2021 American Transplant Congress
Extracellular Vesicles from Patients with Diabetic Nephropathy Induce Endothelial Dysfunction Through Icam-1 and Vcam-1 in an In Vitro Model
*Purpose: Extracellular Vesicles (EVs) are membranous structures produced by cells which contain different cytoplasmic compounds and that have been described as potentially pathogenic elements in…2021 American Transplant Congress
Transgenic Overexpression of Human Ectonucleoside Triphosphate Diphosphohydrolase 1 (entpd1, Or Hcd39) in Pig to Primate Xenotransplantation Models
*Purpose: Human CD39 (hCD39) is the gene of interest in xenotransplantation due to its reported capacity to prevent platelet aggregation by metabolizing extracellular ATP to…2020 American Transplant Congress
Extracellular Vesicles Mediate Endothelial to Mesenchymal Transition and Tubular Senescence in Renal Antibody- Mediated Rejection by Inducing Complement Activation
Emergency and Organ Transplantation, University of Bari, Bari, Italy
*Purpose: EVs (Extracellular vesicles), circulating microparticles able to mediate cell-to cell communication, are emerging as pivotal in different kidney diseases. Renal Antibody-Mediated Rejection (AMR) is…
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