2018 American Transplant Congress
Circulating Wnt Pathway Factors Are Non-Invasive Biomarkers of Transplant Vascular Injury
Purpose: Transplant vascular injury (TVI) is a major cause of renal allograft failure and is resistant to treatment. Non-invasive pathogenic biomarkers of TVI would provide…2018 American Transplant Congress
Ex Vivo Lung Perfusion Using the Portable OCS Maintains Endothelial Integrity in the Context of Reduced Severe PGD Rates
PurposeThe INSPIRE trial revealed significant reduction of PGD grade 3, i.e. less ischemia reperfusion injury (IRI) using the Organ Care System (OCS) compared to controls…2018 American Transplant Congress
An Increase in Spot Urine Protein Excretion during the First Year after Kidney Transplantation Associates with Subclinical De-Novo Donor-Specific Antibodies and Microvascular Inflammation at 1-Year Surveillance Biopsies
Introduction. We investigated whether an increase in spot urine protein excretion during the first year after kidney transplantation associates with subclinical de-novo donor-specific antibodies (DSA)…2018 American Transplant Congress
Assessing the Impact of Flow in Hypothermic Machine Perfusion on Human Venous Endothelium Using a Novel Ex Vivo Model
BACKGROUNDHypothermic machine perfusion (HMP) involves dynamic flow of chilled preservation fluid through an allograft's vasculature. This study describes a simple, reproducible, human model that allows…2018 American Transplant Congress
Peripheral but Not Follicular T Helper Cells Are Activated by Allogeneic Human Endothelial Cells under IRI-Like Conditions and Promote Donor Specific Antibody
Background: Perioperative ischemia reperfusion injury (IRI) is a consequence of solid organ allograft transplantation that primes the graft for future rejection.Methods: We developed an in…2018 American Transplant Congress
Anti-Angiotensin II Type 1-Receptor Antibodies (AT1R-Ab) Induce a Specific Phenotype of Rejection Distinct from HLA Antibody-Mediated Rejection
AT1R-Ab have been associated with kidney allograft rejection; however, their ability to induce a specific rejection phenotype, independent of HLA-DSAs, has not been defined.In a…2018 American Transplant Congress
The Utility of a CD31/CD68 Dual Immunohistochemical Stain to Improve Accurate Diagnosis of Antibody Mediated Rejection in Cardiac Transplantation
Thoracic Pathology, University of Texas Southwestern Medical Center, Dallas, TX.
Antibody mediated rejection (AMR) occurs in 10%-20% of cardiac transplant patients and is associated with increased mortality. The endomyocardial biopsy, used to identify microvascular injury…2018 American Transplant Congress
Endothelial Cell Heterogeneity Governs Basal and Inducible Inflammatory Responses Relevant to Allograft Injury
Pathology and Laboratory Medicine, UCLA, Los Angeles, CA.
PurposeTransplanted tissues are differentially susceptible to ischemia/reperfusion and rejection. Endothelial cells (EC) are active regulators of inflammation. But model EC may not adequately reflect the…2017 American Transplant Congress
Preceeding the Rejection: Clinical Results of a Saliva Test After Renal Transplantation.
Introduction There remains a need for biomarker in transplantation for monitoring and early identification of rejection episodes (R). We developed a colorimetric assay to detect…2017 American Transplant Congress
TRPV4 Channels Mediate Pulmonary Edema and Inflammation During Ischemia-Reperfusion Injury.
University of Virginia, Charlottesville, VA
Rationale: Lung ischemia-reperfusion (IR) injury remains a major challenge in post-transplant patients. Transient receptor potential vanilloid 4 (TRPV4) cation channels mediate cellular calcium influx, and…
American Transplant Congress abstracts