2022 American Transplant Congress
Preoperative Blood Pressure and Risk of Delayed Graft Function in Deceased Donor Kidney Transplantation
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Evaluate association between preoperative blood pressure and delayed graft function (DGF) in deceased donor kidney transplantation (DDKT)*Methods: In this single center study of adult…2022 American Transplant Congress
Cd80 on Effector T Cell Binds Pd-l1 on Lymphatic Endothelial Cells to Fine Tune Migration
*Purpose: Antigen presenting cell (APC) CD80 trans-binds CD28 and CTLA4 on T cells, boosting or inhibiting immunity, respectively. CD80 has another ligand, Programmed Death-1 Ligand…2022 American Transplant Congress
Pro- and Anti-Tolerogenic Microbiota Induce Distinct Gut Microbiome Metabolic Pathways and Loco-Regional Immune Responses
1University of Maryland School of Medicine, Baltimore, MD, 2University of Maryland, Baltimore, MD
*Purpose: Colitis-associated Desulfovibrio desulfuricans (Desulfo) induces pro-inflammatory cytokine responses in dendritic cell and macrophage cell lines as well as primary cells. In contrast, Bifidobacterium pseudolongum…2022 American Transplant Congress
Deficiency of Antibody-Suppressor CXCR5+CD8+ T Cells (Not CD4+ Tregs) Drive High Alloantibody Production in CCR5 KO Kidney Transplant Recipients
*Purpose: Kidney transplant (KTx) into CCR5 KO mice is an excellent model to study AMR immunobiology due to high alloantibody (alloAb) production, rapid allograft rejection,…2022 American Transplant Congress
Alloimmune Recognition Blocks Recipient Macrophage Differentiation into Reparative Subsets
*Purpose: Monocytes differentiate into macrophage subsets that orchestrate tissue repair in response to damage signals and local cytokines. After heart transplant (Tx), graft IL-33 acts…2022 American Transplant Congress
Multidimensional Immunological Profiling of CMV Dnaemia in Kidney Transplant Recipients
*Purpose: Human cytomegalovirus (CMV) infects over half the global population, leading to a mostly asymptomatic but lifelong infection. Primary infection or reactivation in immunocompromised individuals…2022 American Transplant Congress
Off-the-Shelf Allogeneic Invariant NKT Cells Are Safe in the Dog and Induce Both Killer and Regulatory Immune Cells
University of Pennsylvania Veterinary School of Medicine, Philadelphia, PA
*Purpose: Allogeneic invariant Natural Killer T cells (allo-iNKT) are attractive for transplant as they prevent graft rejection and maintain anti-tumor/pathogen effects but do not induce…2022 American Transplant Congress
Hypothermic Pulsatile Flush of Hepatitis C Virus (HCV) RNA Positive Kidney Reduces Viral Load
*Purpose: Does Hypothermic pulsatile flush of hepatitis C virus (HCV) RNA positive kidney reduce the viral load?*Methods: Unutilized, HCV RNA-positive deceased donor kidneys were obtained…2021 American Transplant Congress
CRISPR Screens to Map CTLA-4 Regulatory Networks in Primary Human T Cells
1UCSF, San Francisco, CA, 2Stanford University, Stanford, CA
*Purpose: For most cell types, the pathways that regulate the levels of critical disease-relevant genes are not known. Recent advances in gene editing have enabled…2020 American Transplant Congress
Pre-Transplant Monocyte HDAC6 Expression and Risk of Primary Graft Dysfunction in Clinical Lung Transplant Recipients
*Purpose: Lung transplantation (Tx) in ~30% of cases is subject to primary graft dysfunction (PGD), the severe acute lung injury that occurs within 72 hours…
- 1
- 2
- 3
- 4
- Next Page »