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American Transplant Congress abstracts

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Articles tagged "Calcineurin"

  • 2022 American Transplant Congress

    Evaluation of Different Initial Tacrolimus Dosing Regimens in Pediatric Post-Liver Transplantation

    A. F. Alghanem1, A. Alsmari1, H. Joharji2

    1Pharmaceutical Care, King Abdulaziz Medical City, Riyadh, Saudi Arabia, 2Pharmaceutical Care, King Faisal Specialized Hospital and Research Center, Riyadh, Saudi Arabia

    *Purpose: Tacrolimus is an immunosuppressant used in post-liver transplantation, has wide pharmacokinetic variability, particularly in pediatric patients. Therefore, this study aimed to evaluate different weight-based…
  • 2022 American Transplant Congress

    Long-Term Outcomes After Conversion to a Belatacept-Based Immunosuppression in Kidney Transplant: A Matched Cohort Study

    G. Divard, C. Debiais, C. Legendre, O. Aubert, C. Lefaucheur, A. Loupy

    Paris Transplant Group, INSERM, Paris, France

    *Purpose: Conversion to belatacept after transplant seems to be safe. However, no studies have reported the long-term efficacy and safety outcomes after conversion to belatacept…
  • 2022 American Transplant Congress

    Predicted Performance of Bayesian-Based Precision Dosing Software for Tacrolimus

    A. Seghezzo1, J. Kerr1, A. Gupta2, A. Ta2, L. Powell2, A. Feist3

    1University of California San Diego Health, San Diego, CA, 2PrecisePK, San Diego, CA, 3UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA

    *Purpose: Bayesian-based precision dosing software (BPDS) has been utilized for therapeutic drug monitoring to optimize medication use. However, BPDS for tacrolimus (TAC) is not routinely…
  • 2022 American Transplant Congress

    Conversion to Everolimus-Based Immunosuppression Regimen with Calcineurin Inhibitor Reduction Ameliorates Histological Damage in Kidney Transplant Recipients with Calcineurin Inhibitor-Induced Nephrotoxicity

    K. Hotta, N. Iwahara, T. Tanabe, N. Shinohara

    Hokkaido University Hospital, Sapporo, Japan

    *Purpose: In the last two decades, the short-term results for kidney transplantation (KTX) have improved owing to the use of calcineurin inhibitors (CNIs). However, long-term…
  • 2022 American Transplant Congress

    Kidney Transplant Recipients Not Reaching the Expected Post-Transplant Creatinine Range Most Likely Show Calcineurin-Inhibitor Nephrotoxicity Upon Histology

    S. von Moos1, K. Valkova1, L. Matter1, T. F. Müller1, T. Schachtner2

    1University Hospital Zürich, Zürich, Switzerland, 2University Hospital Zurich, Zürich, Switzerland

    *Purpose: Very recently, our own data suggested that approximately 25% of deceased-donor kidney transplant recipients (KTRs) and 10% of living-donor KTRs don’t reach the expected…
  • 2022 American Transplant Congress

    Impact of Early Calcineurin-Inhibitor Conversion to Belatacept on Renal Allograft Function in a Steroid-Free Maintenance Regimen: Results from a Randomized Controlled Study

    I. Tawhari1, P. Hallak1, S. Hartzell2, V. Mas3, P. Cravedi2, J. Leventhal1, J. Ansari1, L. Gallon1

    1Northwestern University, Chicago, IL, 2Mount Sinai, New York, NY, 3University of Maryland, Baltimore, MD

    *Purpose: Belatacept (Bela) was developed to minimize nephrotoxicity and cardiovascular risk associated with Calcineurin inhibitors (CNIs). Early steroid withdrawal (ESW) and simultaneous CNI avoidance (CNIA)…
  • 2021 American Transplant Congress

    Quantifying the Interaction Between Posaconazole and Tacrolimus in Liver Transplant Recipients: A Practical Approach

    B. Lane1, U. Kaszubski1, A. Freeman1, B. Wise1, L. Hutchinson1, M. Janusek1, G. Therapondos2, H. Bohorquez3, S. Anders1

    1Pharmacy, Ochsner Medical Center, New Orleans, LA, 2Hepatology, Ochsner Medical Center, New Orleans, LA, 3Transplant Surgery, Ochsner Medical Center, New Orleans, LA

    *Purpose: The interaction between tacrolimus (FK) and posaconazole (POSA) is well documented, however the extent of this interaction and the practical management has yet to…
  • 2021 American Transplant Congress

    Systematic Evaluation of Immunosuppressant Drug Tolerability in Lung Transplant Recipients with Short Telomere Syndrome

    R. Patolia1, R. Guzy2, L. Potter1

    1Department of Pharmacy, University of Chicago Medicine, Chicago, IL, 2Department of Medicine, Division of Pulmonology, University of Chicago Medicine, Chicago, IL

    *Purpose: Lung transplant recipients with short telomere syndrome are at high risk of hematologic complications. Consequently, patients with short telomere syndrome may require more frequent…
  • 2021 American Transplant Congress

    Unclear Implications of Tacrolimus Time in Therapeutic Range as a Predictor of Acute Rejection in Renal Transplant Recipients Undergoing Early Corticosteroid Withdrawal

    D. Pierce, P. West-Thielke, Z. Hajjiri, S. Gaitonde, I. Tzvetanov, E. Benedetti, A. Lichvar

    University of Illinois at Chicago, Chicago, IL

    *Purpose: Tacrolimus (TAC) demonstrates a wide intra- and inter-patient variability (IPV) necessitating therapeutic drug monitoring. The purpose of this study is to determine the impact…
  • 2021 American Transplant Congress

    Cognition After Belatacept Conversion (CAB) Trial

    W. Asch1, K. Belfield2, V. Do2, E. Cohen1

    1Yale University, New Haven, CT, 2Yale New Haven Hospital, New Haven, CT

    *Purpose: Extensive adverse effect profiles including neurotoxicity, manifesting as short-term memory loss, make CNIs less desirable despite their efficacy preventing acute rejection and increasing graft…
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