2020 American Transplant Congress
Acute Kidney Injury And Chronic Kidney Disease After Lung Transplantation: Incidence And Risk Factors In A Large Single-center Cohort
Lewis Katz School of Medicine, Temple University, Philadelphia, PA
*Purpose: Chronic kidney disease (CKD) is a common complication after lung transplant. The reported incidence in small studies varies ranges from10-90%. Furthermore, data on risk…2020 American Transplant Congress
Delayed Introduction of Mammalian Inhibitors of Rapamycin (mTOR) Post Kidney Transplantation Might Avoid the Chronic Nephrotoxicity of Calcineurin Inhibitors. Herein We Are Reporting an Eight-Years Single Center Experience of mTOR-Based Immunosuppression Regimen in Comparison with Cyclosporin-Based Regimen
*Purpose: Delayed introduction of mTOR inhibitors post kidney transplantation might avoid the chronic nephrotoxicity of CNI: eight-years single center experience.*Methods: This is a retrospective analysis…2020 American Transplant Congress
Clinical Study of Standard versus Reduced Dose Tacrolimus Combined with Generic Mycophenolate Mofetil in De Novo Kidney Transplantation
Department of Surgery, Ajou University Medical School, Suwon, Korea, Republic of
*Purpose: The lowering of calcineurin inhibitor exposure is possibly considered as the proper strategy to prevent calcineurin inhibitor induced nephrotoxicity in kidney transplant. This clinical…2020 American Transplant Congress
Prospective, Randomized Study of Conversion from Calcineurin Inhibitor (CNI)- to Belatacept (BELA)-Based Maintenance Immunosuppression in Renal Transplant Recipients
*Purpose: CNIs are associated with adverse systemic and nephrotoxic effects that negatively impact long-term patient and graft survival. In a phase 2 study, switching renal…2020 American Transplant Congress
Sirolimus Combined with Low-Dose Calcineurin Inhibitor in Kidney Transplant Recipients from Expanded Criteria Donors
Beijing Friendship Hospital, Capital Medical University, Beijing, China
*Purpose: To evaluate the efficacy and safety of conversion from calcineurin inhibitor-based immunosuppressive regimen to sirolimus combined with low-dose calcineurin inhibitor in recipients with abnormal…2020 American Transplant Congress
Prospective Donor-Specific CellUlar Alloresponse Assessment for Immunosuppression MinImization in De Novo Renal Transplantation: Results of a Randomized Controlled Biomarker-Guided Trial
*Purpose: Early immunosuppression minimization is associated with higher rates of BPAR. Preformed donor-specific T-cell alloreactivity (DST) assessed with an IFN-γ ELISPOT assay has shown to…2020 American Transplant Congress
Early Tacrolimus-LCP Conversion Due to Adverse Effects in Pancreas Transplant Recipients Improves Tolerance But Not Graft Survival
*Purpose: Tacrolimus-LCP (LCPT) is an extended release formulation of tacrolimus which has been shown to have fewer adverse drug effects (ADE) than immediate release tacrolimus…2020 American Transplant Congress
MTOR-Inhibitor Regimens and Malignancy after Kidney Transplantation: Can the Risk Be Modified by Considering Human Leukocyte Antigen (HLA) Mismatch in Immunosuppression Selection?
*Purpose: We investigated the outcomes of mammalian target of rapamycin inhibitor (MTORI) regimens in adult kidney transplant (KT) recipients (KTRs) in categories of donor/recipient pre-transplant…2020 American Transplant Congress
Steroids Ameriplate the Progression of Calcineurin Inhibitors Nephrotoxicity in Kidney Allografts
1Hokkaido University, Sapporo, Japan, 2Sapporo City General Hospital, Sapporo, Japan
*Purpose: Although calcineurin inhibitors (CNI) lead to excellent short-term kidney allograft outcome, chronic nephrotoxicity is a major concern which affects long-term allograft survival. It has…2020 American Transplant Congress
Impact of CYP3A5 Phenotype on Early Time in Therapeutic Range among Pediatric Renal and Heart Transplant Recipients
University of Michigan, Ann Arbor, MI
*Purpose: Tacrolimus time in therapeutic range (TTR) as a measure of intra-patient variability has been associated with poor long-term outcomes. Multiple factors may contribute to…
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