ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Calcineurin"

  • 2022 American Transplant Congress

    Post Transplant Virologic Outcomes in DCD Kidney Transplant Recipients Treated with Thymoglobulin Induction Immunosuppression and Maintenance Belatacept vs Calcineurin Inhibitor Therapy

    T. Engebretsen1, M. Kueht1, A. Lea2, M. Mujtaba3

    1Abdominal Transplant Surgery, University of Texas Medical Branch, Galveston, TX, 2Infectious Disease, University of Texas Medical Branch, Galveston, TX, 3Nephrology, University of Texas Medical Branch, Galveston, TX

    *Purpose: Belatacept is an inhibitor of the T-Cell costimulatory pathway that can be used in recipients of Donation after Circulatory Death (DCD) where the intended…
  • 2022 American Transplant Congress

    Pediatric Liver Transplant Factors That Influence Tacrolimus Absorption

    M. Chandran1, D. Yoeli1, A. Sater2, F. Karrer1, M. Adams1

    1Children's Hospital Colorado, Aurora, CO, 2University of Colorado, Aurora, CO

    *Purpose: The aim of this study was to investigate the association between various pediatric recipient characteristics at time of liver transplant and FK506 absorption 6…
  • 2022 American Transplant Congress

    Impact of Biliary Reconstruction on Tacrolimus Absorption in Pediatric Liver Transplant

    M. Chandran1, D. Yoeli1, A. Sater2, M. Adams1, F. Karrer1

    1Children's Hospital Colorado, Aurora, CO, 2University of Colorado, Aurora, CO

    *Purpose: Tacrolimus (FK506) oral bioavailability in pediatric liver transplant recipients (LTR) is poor. Enteral FK506 is primarily absorbed in the small intestine and subject to…
  • 2022 American Transplant Congress

    Post-Kidney Transplant Dementia Risk by Modifiable Risk Factors and CNIs Among Older Recipients

    Y. Chen1, J. Ahn1, N. Chu1, S. Bae1, M. A. Schnitzler2, G. Hess3, K. Lentine4, D. Segev5, M. McAdams-DeMarco1

    1Johns Hopkins School of Medicine, Baltimore, MD, 2Surgery, Saint Louis University, O Fallon, IL, 3Drexel University School of Medicine, Philadelphia, PA, 4Saint Louis University, St. Louis, MO, 5Johns Hopkins University, Baltimore, MD

    *Purpose: Up to 17% of older recipients develop dementia after kidney transplant (KT). While there are known modifiable risk factors for dementia among community-dwelling older…
  • 2022 American Transplant Congress

    Evaluation of Different Initial Tacrolimus Dosing Regimens in Pediatric Post-Liver Transplantation

    A. F. Alghanem1, A. Alsmari1, H. Joharji2

    1Pharmaceutical Care, King Abdulaziz Medical City, Riyadh, Saudi Arabia, 2Pharmaceutical Care, King Faisal Specialized Hospital and Research Center, Riyadh, Saudi Arabia

    *Purpose: Tacrolimus is an immunosuppressant used in post-liver transplantation, has wide pharmacokinetic variability, particularly in pediatric patients. Therefore, this study aimed to evaluate different weight-based…
  • 2022 American Transplant Congress

    Long-Term Outcomes After Conversion to a Belatacept-Based Immunosuppression in Kidney Transplant: A Matched Cohort Study

    G. Divard, C. Debiais, C. Legendre, O. Aubert, C. Lefaucheur, A. Loupy

    Paris Transplant Group, INSERM, Paris, France

    *Purpose: Conversion to belatacept after transplant seems to be safe. However, no studies have reported the long-term efficacy and safety outcomes after conversion to belatacept…
  • 2021 American Transplant Congress

    A Comparison of Belatacept Conversion Regimens from Calcineurin Inhibitor-Based Immunosuppression

    E. Huang, A. Vo, A. Peng, R. Najjar, S. Sethi, S. Jordan

    Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: Outcomes with varying belatacept conversion protocols from calcineurin inhibitor (CNI)-based immunosuppression have been published but no standard protocol has been established. Beginning in 2012,…
  • 2021 American Transplant Congress

    Higher Calcineurin Inhibitor Levels Associate with Graft Outcomes in Kidney Recipients with De Novo Donor-specific Antibodies of Either Hla Class I or II

    M. Béland, S. De Serres

    Nephrology, CHU de Québec- Université Laval, Québec, QC, Canada

    *Purpose: The development of de novo anti-HLA donor specific antibodies (dnDSA) is associated with poorer outcomes in kidney transplant recipients. We and other previously reported…
  • 2021 American Transplant Congress

    Evaluation of the Conversion from Tacrolimus to Sirolimus in Liver Transplant Recipients

    H. Bakhtiari1, S. Todd2, H. Snyder2, D. Lo2, M. Flynn2

    1Mercer University College of Pharmacy, Atlanta, GA, 2Emory University Hospital, Atlanta, GA

    *Purpose: The purpose of this study was to compare outcomes in liver transplant patients maintained on standard calcineurin inhibitor (CNI) therapy with tacrolimus versus those…
  • 2021 American Transplant Congress

    Early Reduction of Tacrolimus Trough Levels Improves Long-term Kidney Function without Increase in Incidence of Acr

    M. Chen1, B. Loza1, A. Chang1, R. Byfield2, K. Olthoff1, A. Shaked1

    1Department of Surgery, University of Pennsylvania, Philadelphia, PA, 2Data Analytics Center, Penn Medicine Information Systems, University of Pennsylvania Health System, Philadelphia, PA

    *Purpose: We examined the impact of clinical practice management of tacrolimus trough levels in liver transplant recipients on kidney function and incidence of rejection in…
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