Articles tagged "Calcineurin"

2016 American Transplant Congress
Impact on Wound Healing Events After Early Conversion to Everolimus in De Novo Renal Transplant Recipients: 24-Month Results from the Randomized ELEVATE Study.
B. Nashan,¹ M. van der Giet,¹ H. Holdaas,¹ M. Zeier,¹ J. Pascual,¹ Y. Avihingsanon,¹ P. Lopez,² J. Aguilar-Sanchez,² J. Kochuparampil,² Z. Wang,³ J. Cruzado,¹ J. De Fijter.¹
¹ELEVATE Study Group, Hamburg, Germany; ²Novartis, Basel, Switzerland; ³Novartis Pharmaceutical Corporation, East Hanover.
BackgroundWound healing events (WHE) are probably the most common type of post-transplant (Tx) surgical complication. Due to its antiproliferative properties, mammalian target of rapamycin inhibitors…
2016 American Transplant Congress
The Use of Sofosbuvir (SOF)-Containing Direct Antiviral Agents (DAA)-Based Regimens Requires Increase in Tacrolimus (Tac) Doses in Kidney Transplant (KT) Recipients with Hepatitis C Virus (HCV) Infection.
N. Polanco Fernandez,¹ A. García Santiago,¹ M. Fernández Ruiz,² R. Muñoz,³ C. Alvarez Vazquez,⁴ A. Hernandez,¹ V. Mercado,¹ E. González Monte,¹ I. Fernández,³ J. Aguado,² M. Praga,¹ A. Andres.¹
¹Nephrology, Hospital Universitario “12 de Octubre”, Madrid, Spain; ²Unit of Infectious Diseases, Hospital Universitario “12 de Octubre”, Madrid, Spain; ³Gastroenterology, Hospital Universitario “12 de Octubre”, Madrid, Spain; ⁴Biochemistry, Hospital Universitario “12 de Octubre”, Madrid, Spain.
Background: The use of SOF-containing regimens based on NS5A inhibitors has not been shown interactions with Tac in liver transplant.Specific data on KT recipients are…
2016 American Transplant Congress
Prospective Randomized Study of a Steroid Free, Low Dose Tacrolimus with Everolimus Regimen in Kidney Transplant.
A. Shetty, O. Traitanon, M. Ansari, J. Mathew, J. Leventhal, V. Mas, L. Gallon.
Northwestern University, Chicago, IL; University of Virginia, Chicago, IL.
Calcineurin inhibitors (CNI) serve as the cornerstone of immunosuppression (IS) after kidney transplant. However chronic CNI nephrotoxicity has been implicated in allograft dysfunction. We hypothesize…
2016 American Transplant Congress
Everolimus and Low Dose Cyclosporine Immunosuppressive Regimen and Development of Anti HLA Donor Specific Antibodies.
E. Minetti,¹ L. Di Maria,¹ L. Caroti,¹ E. Buti,² P. Carta.¹
¹Nephrology unit, Careggi University Hospital, Florence, Italy; ²Nephrology Unit, Mayer Univerity Hospital, Florence, Italy.
Few data are available on the rate of de novo anti-HLA donor specific antibodies (DSA) with the use of everolimus in kidney transplant recipients.MaterialsWe selected…
2016 American Transplant Congress
Calcineurin Inhibitor (CNI) Delay with ATG Induction: Teaching an Old Dog, New Tricks.
A. Aliabadi,¹ J. Goekler,¹ O. Salameh,¹ T. Haberl,¹ B. Steinlechner,² P. Opfermann,² A. Kaider,¹ K. Uyanik-Uenal,¹ G. Laufer,¹ A. Zuckermann.¹
¹Cardiac Surgery, Medical University of Vienna, Vienna, Austria; ²Cardiothoracic and Vascular Anaesthisiology, Medical University of Vienna, Vienna, Austria.
CNI delay early after heart transplantation is a recommended therapeutic option according to ISHLT guidelines. However, there exist only few published data on feasibility of…
2016 American Transplant Congress
Pharmakokinetics of Prolonged-Release Formulation of Tacrolimus: Comparison of AUC0-24 and Concentration at 10 Time Points.
K. Unagami,¹ M. Okumi,² M. Furusawa,² T. Hirai,² T. Shimizu,² K. Omoto,² M. Inui,² H. Ishida,² K. Nitta,¹ K. Tanabe.²
¹Nephrology, Tokyo Women's Medical University, Tokyo, Japan; ²Urology, Tokyo Women's Medical University, Tokyo, Japan.
Background:Use of an appropriate immunosuppressant is necessary for good graft survival in kidney transplantation (KTx). Currently, a prolonged-release formulation of tacrolimus (Graceptor or Adovagraf, Astellas…
2016 American Transplant Congress
Calcineurin Inhibitor (CNI) Nephrotoxicity Is Mediated by Defective Amp-Activated Protein Kinase (AMPK) Activation.
A. Zmijewska, J. Chen, J. Zmijewski, R. Mannon.
Medicine, UAB, Birmingham, AL.
Background: CNIs are potent immunosuppressant therapies, but associated with nephrotoxicity manifested by interstitial fibrosis and progressive graft dysfunction. AMPK is a major sensor and regulator…
2016 American Transplant Congress
Novel Nuclear Factor-κB Activation Inhibitor, Dehydroxymethylepoxyquinomicin, Prevents the Development of Chronic Cyclosporine Nephropathy in Rats.
S. Morita,¹ K. Shinoda,¹ S. Tamaki,¹ H. Kono,² Y. Kanno,³ K. Umezawa,⁴ K. Nakagawa,² M. Oya.¹
¹Urology, Keio University School of Medicine, Tokyo, Japan; ²Urology, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Chiba, Japan; ³Nephrology, Tokyo Medical University, Tokyo, Japan; ⁴Molecular Target Medicine Screening, Aichi Medical University, Nagakute, Aichi, Japan.
Purpose:The nephrotoxicity of the calcineurin inhibitors including cyclosporine is a major problem in the kidney transplantation. We investigated the effect of a novel nuclear factor-κB…
2016 American Transplant Congress
Genomic-Derived Markers to Identify Calcineurin Inhibitor Nephrotoxicity in Pediatric Kidney Transplant Recipients.
E. Rhone,¹ R. Gehrau,² S. Bontha,² P. Walker,³ C. Dumur,⁴ D. Maluf,² V. Mas.²
¹Pediatrics, University of Virginia, Charlottesville, VA; ²Surgery, University of Virginia, Charlottesville, VA; ³Nephropath, Little Rock, AR; ⁴Pathology, Virginia Commonwealth University, Richmond, VA.
Background:Calcineurin inhibitor nephrotoxicity (CNIT) is a well-known contributor to chronic allograft dysfunction in kidney transplant recipients (KTRs). Pediatric KTRs are particularly at risk given their…
2016 American Transplant Congress
Adding an Antimetabolite to a Calcineurin-Inhibitor-Based Immunosuppression Regimen Leads to Improved Native Renal Function After Liver Transplantation.
A. Karim, D. Conway, G. Leverson, J. Mezrich, L. Fernandez, A. D'Alessandro, D. Foley.
Surgery, University of Wisconsin, Madison, WI.
Background: Nephrotoxic side effects of calcineurin inhibitors (CNI) have been well established. The addition of anti-metabolites (AM) to CNI-based immunosuppression (IS) regimens has been proposed…