ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Long-Term Low-Dose Corticosteroid Therapy Can Suppress Calcineurin Inhibitor Induced Nephrotoxicity without Steroid-Related Complication in Living Kidney Transplant Recipient

H. Sasaki, H. Harada, D. Takamoto, Y. Takada, S. Harada, H. Tanaka

Sapporo City General Hospital, Sapporo, Japan

Meeting: 2022 American Transplant Congress

Abstract number: 1375

Keywords: Calcineurin, Induction therapy, Kidney transplantation, Nephrotoxicity

Topic: Clinical Science » Kidney » 37 - Kidney Immunosuppression: Induction Therapy

Session Information

Session Name: Kidney Immunosuppression: Induction Therapy

Session Type: Poster Abstract

Date: Monday, June 6, 2022

Session Time: 7:00pm-8:00pm

 Presentation Time: 7:00pm-8:00pm

Location: Hynes Halls C & D

*Purpose: The induction of calcineurin inhibitors (CNI) greatly reduced the rate of allograft rejection, although their chronic use resulted in vascular inflammation in kidney transplant recipients. We evaluated whether corticosteroid therapy as anti-inflammatory agent may prevent CNI nephrotoxicity.

*Methods: 91 patients who underwent ABO compatible kidney transplant (KT) from living-related donors in our hospital were enrolled. Among 91, 43 recipients received daily low-dose methylprednisolone in addition to tacrolimus (TAC) and mycophenolate mofetil (MMF) (Chronic steroid group). Historical control group was composed of 48 recipients who were treated with TAC, MMF and only 3-days of perioperative methylprednisolone (Corticosteroid early discontinuation: CSED group). Basiliximab was also used as induction mAb in each group. Patient and graft survival, the incidence of acute and chronic rejection, Banff aah-score indicating CNI nephrotoxicity,steroid-related adverse effects were analyzed retrospectively.

*Results: There were no statistical differences in age at transplant, sex, donor age, HLA- mismatch and duration of renal replacement therapy between the two groups, but observed period was significantly longer in chronic steroid group. (14y vs 10y, p<0.001) Patient and graft survival were comparable at 10 years after KT between Chronic steroid and CSED group. (97% vs 89% p=0.09, 91% vs 85% p=0.74, respectively) Incidence of acute and chronic rejection was also similar. In pathological study, however, aah-score was markedly decreased in chronic steroid at 5 year after KT compared to CSED group (0.22 vs 0.97, p=0.04) (Fig. 1) despite of no difference in TAC-trough during 5 years (Fig.2), suggesting that chronic steroid may suppress CNI nephrotoxicity. On the other hand, the incidence of de novo DM, infection and cancer was equivalent as well as lumbar bone density which was shown by % young adult mean. (Fig. 3 and 4)

*Conclusions: Long-term low-dose corticosteroid therapyhas achieved promising graft outcome with suppressing CNI nephrotoxicityin addition to steroid associated complication.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Sasaki H, Harada H, Takamoto D, Takada Y, Harada S, Tanaka H. Long-Term Low-Dose Corticosteroid Therapy Can Suppress Calcineurin Inhibitor Induced Nephrotoxicity without Steroid-Related Complication in Living Kidney Transplant Recipient [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/long-term-low-dose-corticosteroid-therapy-can-suppress-calcineurin-inhibitor-induced-nephrotoxicity-without-steroid-related-complication-in-living-kidney-transplant-recipient/. Accessed June 23, 2025.

« Back to 2022 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences