2019 American Transplant Congress
Galectin-3 Levels Are Associated with the Incidence and Severity of Chronic GVHD One Year after Allogeneic Hematopoietic Cell Transplantation
*Purpose: Chronic graft-versus-host disease (cGVHD) is a frequent complication of allogeneic hematopoietic cell transplantation (HCT) and a leading cause of late morbidity and mortality. T-…2019 American Transplant Congress
Quality of Life in Tolerant Living Donor Kidney Transplants vs. Standard of Care
1Regenerex, Inc., Louisville, KY, 2Northwestern U, Chicago, IL, 3U of Louisville, Louisville, KY
*Purpose: 37 subjects have been transplanted since 2009 in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts. The protocol…2019 American Transplant Congress
Prevention of Diabetes in the NOD Mice Reconstituted with Bone Marrow Cells from Allogeneic CD4 Knockout, CD8 Knockout or B-Cell Knockout B6 Mice
University of Louisville, Louisville, KY
*Purpose: Type 1 diabetes (T1D) is an autoimmune disorder characterized by destruction of the pancreatic beta cells by both humoral- and cell-mediated immune mechanisms. Transplantation…2019 American Transplant Congress
Donor-Specific Tregs Prolong Peripheral Chimerism in Baboons Receiving GalTKO hCD47-tg Porcine Peripheral Blood Stem Cells
*Purpose: We have previously evaluated the ability of transplantation of polyclonal expanded recipient T regulatory cells to prolong xenogeneic chimerism and skin grafts after transplantation…2018 American Transplant Congress
Low Intensity Conditioning Protocol for Inducing Chimerism-Based Tolerance in Non-Obese Diabetic Mice
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.
Type 1 diabetes is the most common chronic disease affecting children. Islet cell or pancreas transplantation offer the most physiologic approach to glucose homostasis. However…2018 American Transplant Congress
Outcomes after Kidney Transplantation in Patients with AL Amyloid Following Autologous Stem Cell Transplantation
BackgroundAL amyloidosis results in kidney failure in about 15-30% of patients and is considered a relative contraindication for kidney transplantation. There is limited data on…2018 American Transplant Congress
A Novel Protocol to Improve Kidney Transplant Outcomes in Patients with Renal Disease Due to Amyloidosis
Vanderbilt University Medical Center, Nashville, TN.
In 2011, members from 10 different medical disciplines formed the Vanderbilt Amyloid Multidisciplinary Program (VAMP) in an effort to improve regional recognition of this rare…2018 American Transplant Congress
Building a Third-Party VST Bank from Scratch- The Cincinnati Experience
BackgroundViral infections remain a challenge to treat and significantly contribute to morbidity and mortality. Virus specific T cells (VSTs) have shown clinical efficacy, with minimal…2018 American Transplant Congress
RNA Expression Profiling of Renal Allografts in a Non-Human Primate Identifies Inflammation as a Risk Factor in Chronic Antibody Mediated Rejection
IntroductionChronic alloantibody mediated rejection (CAMR) is a major risk factor in renal allografts. Some inflammation is commonly identified within CAMR, though mostly low grade, and…2018 American Transplant Congress
RNA Expression Profiling of Renal Allografts in the Cynomolgus Monkey Identifies Tolerance
IntroductionTolerance induction is a long standing clinical goal. However, identification remains elusive. Here we profile intra-renal allograft RNA expression in a mixed chimerism renal allograft…
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