2019 American Transplant Congress
Expansion of Regulatory T and B Cells in Swine Rendered Tolerant of Allogeneic Vascularized Composite Allografts via Mixed Chimerism
*Purpose: Prevention of acute rejection of vascularized composite allografts (VCAs) requires ongoing systemic immunosuppression, which subject patients to infectious, metabolic, reno-vascular and neoplastic complications. It…2019 American Transplant Congress
Ten Year Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients
1Northwestern U, Chicago, IL, 2Duke U, Durham, NC, 3U Louisville, Louisville, KY
*Purpose: 37 subjects have been transplanted in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts (KTx) based upon tolerogenic…2019 American Transplant Congress
After 10 Years: The Results of HLA Mismatched Combined Kidney and Bone Marrow Transplantation for Renal Allograft Tolerance
1Massachusetts General Hospital, Boston, MA, 2Columbia University, NYC, NY
*Purpose: Based on decades-long basic studies in animal models, we have applied combined kidney and donor bone marrow transplantation (CKBMT) for induction of allograft tolerance…2019 American Transplant Congress
Conceptual Extension of SNP Based Abundance Profiling to Infer Donor Derived Cell-Free DNA Fraction as an Indication of Organ Rejection
R&D, Viracor-Eurofins, Lee's Summit, MO
*Purpose: Rejection is a major post-transplant complication for organ transplant recipients. Biopsy remains the standard to diagnose rejection, but other non-invasive methods, such as transcript…2018 American Transplant Congress
Immunity and Tolerance after Bilateral Orthotopic Lung Transplant (BOLT) in Tandem with a CD3+/CD19+ Depleted Vertebral Bone Marrow Transplant (BOLT+BMT) from 1 of 8 HLA-Matched Cadaveric Donors
Primary immunodeficiency patients may develop pulmonary complications and most are ineligible for either lung transplant or BMT due to futility. We report our first 2…2018 American Transplant Congress
Changes in Phenotype, Immune Suppressive, Function, and Gene Expression of Myeloid Derived Suppressor Cells in Patients Given Combined Kidney and Hematopoietic Cell Transplants in a Tolerance Protocol
Tolerance induction after combined organ and hematopoietic cell transplantation can be achieved using conditioning with total lymphoid irradiation (TLI) and anti-thymocyte globulin (ATG), in both…2018 American Transplant Congress
Recipient Conditioning Results in IL-33 Support of Potent Th1 Alloimmune Responses after CD4+ T Cells Upregulate ST2 during Lymphopenia Induced Proliferation
Purpose: IL-33 is typically associated with support of Th2 and Treg responses. Yet, recipient conditioning before allogeneic hematopoietic cell transplantation (alloHCT) releases IL-33 to promote…2018 American Transplant Congress
Long-Term Nonhuman Primate Renal Allograft Survival without Ongoing Immunosuppression in Recipients of Delayed Donor Bone Marrow Transplantation
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
Background: We have previously reported induction of renal allograft tolerance in nonhuman primates following an initial post-transplant period of conventional immunosuppression (IS) using a nonmyeloablative…2018 American Transplant Congress
A Novel Conditioning Approach to Establish Chimerism Using Manipulation of JAK-STAT Pathways
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.
Hematopoietic chimerism establishes donor-specific tolerance to solid organ allografts. Targeting recipient immune cells (T, NK cells and macrophages) can effectively reduce the dose of total…2018 American Transplant Congress
Characterization of Renal Allograft Tolerance Induction via Transient Mixed Chimerism in Non-Human Primates
Background: We have previously reported long-term renal allograft tolerance after induction of transient mixed chimerism in non-human primates. However, some recipients developed late onset chronic…
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