Articles tagged "Bone marrow transplantation"

2019 American Transplant Congress
Galectin-3 Levels Are Associated with the Incidence and Severity of Chronic GVHD One Year after Allogeneic Hematopoietic Cell Transplantation
N. Navarro-Alvarez¹, A. R. Andrews¹, Z. DeFilipp², Y. A. Chen², V. T. Ho³, J. Ritz³, T. R. Spitzer⁴, C. A. Huang⁵
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Blood and Marrow Transplant Program, Massachusetts General Hospital, Boston, MA, ³Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA, ⁴Hematology/Oncology, Massachusetts General Hospital, Boston, MA, ⁵Plastic & Reconstructive Surgery and Transplant Surgery Divisions, University of Colorado, Denver, Aurora, CO
*Purpose: Chronic graft-versus-host disease (cGVHD) is a frequent complication of allogeneic hematopoietic cell transplantation (HCT) and a leading cause of late morbidity and mortality. T-…
2019 American Transplant Congress
Quality of Life in Tolerant Living Donor Kidney Transplants vs. Standard of Care
D. Tollerud¹, J. Leventhal², J. Galvin², J. Mathew², L. Gallon², D. Stare², J. Miller², M. Abecassis², S. Ildstad³
¹Regenerex, Inc., Louisville, KY, ²Northwestern U, Chicago, IL, ³U of Louisville, Louisville, KY
*Purpose: 37 subjects have been transplanted since 2009 in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts. The protocol…
2019 American Transplant Congress
Prevention of Diabetes in the NOD Mice Reconstituted with Bone Marrow Cells from Allogeneic CD4 Knockout, CD8 Knockout or B-Cell Knockout B6 Mice
Y. Huang, H. Xu, Y. Wen, S. Ildstad
University of Louisville, Louisville, KY
*Purpose: Type 1 diabetes (T1D) is an autoimmune disorder characterized by destruction of the pancreatic beta cells by both humoral- and cell-mediated immune mechanisms. Transplantation…
2019 American Transplant Congress
Donor-Specific Tregs Prolong Peripheral Chimerism in Baboons Receiving GalTKO hCD47-tg Porcine Peripheral Blood Stem Cells
N. P. Llore¹, J. Stern¹, G. Pierre¹, E. Lopes¹, D. Ekanayake-Alper¹, P. Alonso-Guallart¹, K. Bruestle¹, H. Sakai¹, D. Ayares², M. Lorber², R. Hawley¹, D. H. Sachs¹, M. Sykes¹, A. D. Griesemer¹
¹Columbia Center for Translational Immunology, New York, NY, ²United Therapeutics, Silver Springs, MD
*Purpose: We have previously evaluated the ability of transplantation of polyclonal expanded recipient T regulatory cells to prolong xenogeneic chimerism and skin grafts after transplantation…
2018 American Transplant Congress
RNA Expression Profiling of Renal Allografts in a Non-Human Primate Identifies Inflammation as a Risk Factor in Chronic Antibody Mediated Rejection
R. Smith,¹ B. Adam,² A. Rosales,¹ M. Matsunami,³ T. Oura,³ B. Cosimi,³ T. Kawai,³ M. Mengel,² R. Colviin.¹
¹Pathology, Massachusetts General Hospital, Boston, MA; ²Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ³Surgery, Massachusetts General Hospital, Boston, MA.
IntroductionChronic alloantibody mediated rejection (CAMR) is a major risk factor in renal allografts. Some inflammation is commonly identified within CAMR, though mostly low grade, and…
2018 American Transplant Congress
RNA Expression Profiling of Renal Allografts in the Cynomolgus Monkey Identifies Tolerance
R. Smith,¹ M. Matsunami,³ B. Adam,² A. Rosales,¹ T. Oura,³ A. Cosimi,³ T. Kawai,³ M. Mengel,² R. Colvin.¹
¹Pathology, Massachusetts General Hospital, Boston, MA; ²Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ³Department of Surgery, Massachusetts General Hospital, Boston, MA.
IntroductionTolerance induction is a long standing clinical goal. However, identification remains elusive. Here we profile intra-renal allograft RNA expression in a mixed chimerism renal allograft…
2018 American Transplant Congress
Relationship between Mixed Chimerism and Acceptance of HLA-Matched and Mismatched Kidney Transplants after Withdrawal of Immunosuppressive Drugs
J. Scandling, S. Busque, R. Lowsky, J. Shizuru, K. Jensen, A. Shori, E. Engleman, E. Meyer, R. Hoppe, S. Strober.
Stanford University, Stanford, CA.
Classical studies in cattle and rodents showed that mixed chimerism (MXC) established in fetuses and neonates was permanent, linked to immune tolerance and graft acceptance…
2018 American Transplant Congress
Long-Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients
J. Leventhal,¹ J. Galvin,¹ J. Mathew,¹ L. Gallon,¹ D. Stare,¹ K. Kurtenbach,¹ K. Ravindra,³ M. Horwitz,³ J. Miller,¹ M. Abecassis,¹ S. Ildstad.²
¹Surgery, Northwestern U, Chicago; ²U of Louisville, Louisville; ³Duke U, Durham.
37 pts have been transplanted in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts (KTx). The protocol is based…
2018 American Transplant Congress
Immunity and Tolerance after Bilateral Orthotopic Lung Transplant (BOLT) in Tandem with a CD3+/CD19+ Depleted Vertebral Bone Marrow Transplant (BOLT+BMT) from 1 of 8 HLA-Matched Cadaveric Donors
P. Szabolcs,¹ X. Chen,¹ A. Donnenberg,² M. Hill,¹ J. Rowan,¹ S. Mcintyre,¹ G. Kurland,¹ J. Barnum,¹ J. McDyer.¹
¹BMT-CT, Children Hospital of Pittsburgh UPMC, Pittsburgh, PA; ²IDM-HCC, University of Pittsburgh, Pittsburgh, PA.
Primary immunodeficiency patients may develop pulmonary complications and most are ineligible for either lung transplant or BMT due to futility. We report our first 2…
2018 American Transplant Congress
Changes in Phenotype, Immune Suppressive, Function, and Gene Expression of Myeloid Derived Suppressor Cells in Patients Given Combined Kidney and Hematopoietic Cell Transplants in a Tolerance Protocol
K. Jensen,¹ P. Zheng,² J. Xuhuai,² A. Saraswathula,¹ J. Scandling,³ S. Busque,⁴ J. Shizuru,⁵ R. Lowsky,⁵ A. Shori,⁴ H. Maecker,² E. Engleman,¹ E. Meyer,⁵ S. Strober.¹
¹Immunology, Stanford School of Medicine, Stanford, CA; ²Human Immune Monitoring Center, Stanford School of Medicine, Stanford, CA; ³Nephrology, Stanford School of Medicine, Stanford, CA; ⁴Surgery, Stanford School of Medicine, Stanford, CA; ⁵Blood & Marrow Transplantation, Stanford School of Medicine, Stanford, CA.
Tolerance induction after combined organ and hematopoietic cell transplantation can be achieved using conditioning with total lymphoid irradiation (TLI) and anti-thymocyte globulin (ATG), in both…