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American Transplant Congress abstracts

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Articles tagged "Bone marrow transplantation"

  • 2019 American Transplant Congress

    Galectin-3 Levels Are Associated with the Incidence and Severity of Chronic GVHD One Year after Allogeneic Hematopoietic Cell Transplantation

    N. Navarro-Alvarez1, A. R. Andrews1, Z. DeFilipp2, Y. A. Chen2, V. T. Ho3, J. Ritz3, T. R. Spitzer4, C. A. Huang5

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Blood and Marrow Transplant Program, Massachusetts General Hospital, Boston, MA, 3Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA, 4Hematology/Oncology, Massachusetts General Hospital, Boston, MA, 5Plastic & Reconstructive Surgery and Transplant Surgery Divisions, University of Colorado, Denver, Aurora, CO

    *Purpose: Chronic graft-versus-host disease (cGVHD) is a frequent complication of allogeneic hematopoietic cell transplantation (HCT) and a leading cause of late morbidity and mortality. T-…
  • 2019 American Transplant Congress

    Quality of Life in Tolerant Living Donor Kidney Transplants vs. Standard of Care

    D. Tollerud1, J. Leventhal2, J. Galvin2, J. Mathew2, L. Gallon2, D. Stare2, J. Miller2, M. Abecassis2, S. Ildstad3

    1Regenerex, Inc., Louisville, KY, 2Northwestern U, Chicago, IL, 3U of Louisville, Louisville, KY

    *Purpose: 37 subjects have been transplanted since 2009 in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts. The protocol…
  • 2019 American Transplant Congress

    Prevention of Diabetes in the NOD Mice Reconstituted with Bone Marrow Cells from Allogeneic CD4 Knockout, CD8 Knockout or B-Cell Knockout B6 Mice

    Y. Huang, H. Xu, Y. Wen, S. Ildstad

    University of Louisville, Louisville, KY

    *Purpose: Type 1 diabetes (T1D) is an autoimmune disorder characterized by destruction of the pancreatic beta cells by both humoral- and cell-mediated immune mechanisms. Transplantation…
  • 2019 American Transplant Congress

    Donor-Specific Tregs Prolong Peripheral Chimerism in Baboons Receiving GalTKO hCD47-tg Porcine Peripheral Blood Stem Cells

    N. P. Llore1, J. Stern1, G. Pierre1, E. Lopes1, D. Ekanayake-Alper1, P. Alonso-Guallart1, K. Bruestle1, H. Sakai1, D. Ayares2, M. Lorber2, R. Hawley1, D. H. Sachs1, M. Sykes1, A. D. Griesemer1

    1Columbia Center for Translational Immunology, New York, NY, 2United Therapeutics, Silver Springs, MD

    *Purpose: We have previously evaluated the ability of transplantation of polyclonal expanded recipient T regulatory cells to prolong xenogeneic chimerism and skin grafts after transplantation…
  • 2018 American Transplant Congress

    Low Intensity Conditioning Protocol for Inducing Chimerism-Based Tolerance in Non-Obese Diabetic Mice

    A. Chhabra, Y. Huang, H. Xu, A. Merchak, S. Ildstad.

    Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.

    Type 1 diabetes is the most common chronic disease affecting children. Islet cell or pancreas transplantation offer the most physiologic approach to glucose homostasis. However…
  • 2018 American Transplant Congress

    Outcomes after Kidney Transplantation in Patients with AL Amyloid Following Autologous Stem Cell Transplantation

    V. Gutgarts,1,2 I. Jaffer Sathick,2 C. Rosenbaum,3 T. Muthukumar,1 H. Hassoun,4 C. Flombaum,2 H. Landau.4

    1Nephrology, Weill Cornell, NY; 2Renal Medicine, Memorial Sloan Kettering, NY; 3Hematology, Weill Cornell, NY; 4Hematology, Memorial Sloan Kettering, NY.

    BackgroundAL amyloidosis results in kidney failure in about 15-30% of patients and is considered a relative contraindication for kidney transplantation. There is limited data on…
  • 2018 American Transplant Congress

    A Novel Protocol to Improve Kidney Transplant Outcomes in Patients with Renal Disease Due to Amyloidosis

    A. Langone, B. Concepcion, D. Slosky, R. Cornell, S. Horst, S. Goodman.

    Vanderbilt University Medical Center, Nashville, TN.

    In 2011, members from 10 different medical disciplines formed the Vanderbilt Amyloid Multidisciplinary Program (VAMP) in an effort to improve regional recognition of this rare…
  • 2018 American Transplant Congress

    Building a Third-Party VST Bank from Scratch- The Cincinnati Experience

    A. S. Nelson,1 D. Heyenbruch,2 X. Zhu,3 S. M. Davies,1 C. Lutzko,3 C. Bollard,4 P. Hanley,4 T. Leemhuis,2 L. Danziger-Isakov,5 M. S. Grimley.1

    1Bone Marrow Transplant & Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; 2Hoxworth Blood Center, Univeristy of Cincinnati, Cincinnati, OH; 3Experimental Hematology & Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; 4Proram for Cell Enhancement and Technologies for Immunotherapy, Children's National Health System, Washington, DC; 5Depatment of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

    BackgroundViral infections remain a challenge to treat and significantly contribute to morbidity and mortality. Virus specific T cells (VSTs) have shown clinical efficacy, with minimal…
  • 2018 American Transplant Congress

    RNA Expression Profiling of Renal Allografts in a Non-Human Primate Identifies Inflammation as a Risk Factor in Chronic Antibody Mediated Rejection

    R. Smith,1 B. Adam,2 A. Rosales,1 M. Matsunami,3 T. Oura,3 B. Cosimi,3 T. Kawai,3 M. Mengel,2 R. Colviin.1

    1Pathology, Massachusetts General Hospital, Boston, MA; 2Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; 3Surgery, Massachusetts General Hospital, Boston, MA.

    IntroductionChronic alloantibody mediated rejection (CAMR) is a major risk factor in renal allografts. Some inflammation is commonly identified within CAMR, though mostly low grade, and…
  • 2018 American Transplant Congress

    RNA Expression Profiling of Renal Allografts in the Cynomolgus Monkey Identifies Tolerance

    R. Smith,1 M. Matsunami,3 B. Adam,2 A. Rosales,1 T. Oura,3 A. Cosimi,3 T. Kawai,3 M. Mengel,2 R. Colvin.1

    1Pathology, Massachusetts General Hospital, Boston, MA; 2Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; 3Department of Surgery, Massachusetts General Hospital, Boston, MA.

    IntroductionTolerance induction is a long standing clinical goal. However, identification remains elusive. Here we profile intra-renal allograft RNA expression in a mixed chimerism renal allograft…
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