2016 American Transplant Congress
Randomized Controlled Study Evaluating Adherence Monitoring with Electronic Feedback on Reducing Renal Allograft Rejection.
Transplant Center, University of Chicago, Chicago, IL.
Purpose: The negative impact of non-adherence to the immunosuppressant medication (IM) regimen on transplant outcomes is well recognized. In an attempt to improve outcomes, the…2016 American Transplant Congress
A Novel Quantitative CD45 Immunofluorescence Assay Can Measure Inflammatory Load in Renal Transplant Biopsies with Excellent Reproducibility and Repeatability.
1UCSF, San Francisco, CA; 2Rho, Chapel Hill, NC.
Purpose: The interobserver reproducibility of the current standard semiquantitative (Banff) grading of inflammation in renal transplant biopsies (TxBx) is suboptimal. We have recently developed a…2016 American Transplant Congress
Unexpected Early Calcineurin Inhibitor Nephrotoxicity in Pediatric Kidney Transplant Recipients.
Background: Calcineurin inhibitors effectively suppress the recipient immune response and facilitate early success in kidney transplantation. However, these drugs are potent nephrotoxins and contribute to…2015 American Transplant Congress
Is Electron Microscopy Adding a Diagnostic Advantage in the Evaluation of Renal Allograft Biopsies for Antibody Mediated Rejection (AMR)?
Pathology and Medicine, University of Maryland School of Medicine, Baltimore, MD.
Some electron microscopy (EM) findings have been consistently associated with antibody mediated microvascular injury; however, no large studies have been performed examining the concrete advantage…2015 American Transplant Congress
The Impact of Therapy On the Inflammatory Infiltrate in Renal Allografts With Acute and Chronic Antibody Mediated Rejection
Little is known about the effect of usual treatment for acute and chronic antibody mediated rejection (aAMR and cAMR) on inflammatory cells within the allograft.…2015 American Transplant Congress
Single Center Experience of C4d Staining of Kidney Transplant Biopsies
Division of Nephrology and Transplant Institute, Henry Ford Hospital, Detroit, MI.
Introduction: While a diffuse positivity (>50%) of C4d in kidney transplant peritubular capillaries strongly co-relates with the presence of acute or chronic antibody mediated rejection,…2015 American Transplant Congress
Clinical Subclassifiation of ABMR Phenotypes: Recognizing Variation in Presentation
Alberta Transplant Applied Genomics Centre, Edmonton, Canada.
The diagnosis of ABMR in kidney transplants is based on ptc-, g- and cg-lesions in biopsies and donor-specific antibody (DSA). To recognize the actual phenotypes…2015 American Transplant Congress
NK-Cell Subset Distribution, Renal Function and Biopsy Findings in Kidney Transplant Recipients With HLA Donor-Specific Antibodies
Background: Detection of post-transplant donor-specific anti-HLA antibodies(DSA) constitutes a risk factor for kidney transplant (KT) loss. NK-cell antibody-dependent cell mediated cytotoxicity(ADCC) has been proposed to…2015 American Transplant Congress
Gene Expression Profiles Indicate That Many Discarded Kidneys Are Potentially Transplantable
1University of Alberta, Edmonton, Canada; 2University of Marlyland, Baltimore.
We previously showed that the molecular kidney injury-repair response (AKI score) in implantation core biopsies (Bx) predict future graft function better than histology. This could…2015 American Transplant Congress
Arterial Blood Pressure at Time of Liver Transplant (LT) Evaluation Correlates With Kidney Biopsy Findings in LT Candidates With Renal Dysfunction
Transplant, Mayo Clinic, Jacksonville, FL.
Renal dysfunction is common in LT candidates; however, predicting post-LT renal recovery is sometimes difficult. Kidney biopsy is helpful in identifying reversible renal injury but…
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