Articles tagged "Biopsy"

2016 American Transplant Congress
Clinical Significance of Isolated v1 Arteritis in Renal Transplantation.
D. Mikhail,^1,3 J. Wei,³ D. Kleinsteuber,² M. Gabril,^2,3 A. Sener,^1,3 M. Moussa,^2,3 P. Luke.^1,3
¹Department of Surgery, Division of Urology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; ²Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; ³Undergraduate Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
INTRO: The presence of intimal arteritis (v) in renal transplant biopsies (Bx) establishes Grade II-III AVR (Acute Vascular Rejection) according to the Banff Classification. The…
2016 American Transplant Congress
Late Outcome Surrogate Score (LOSS) for Kidney Allograft Failure.
B. Ho, L. Zhao, S. Montag, D. Ladner, M. Abecassis, A. Skaro.
Comprehensive Transplant Center, Northwestern University, Chicago, IL.
Background. Early outcomes following kidney transplant have steadily improved. Longer-term outcomes, while not the focus of regulatory oversight, are of vital importance. Clinical trials are…
2016 American Transplant Congress
Systematic Pathological Component Scores for Skin-Containing Vascularized Composite Allografts.
I. Rosales,¹ M. DeFazio,² R. Foreman,¹ D. Sachs,² C. Cetrulo,² D. Leonard,^2,3 R. Colvin.¹
¹Pathology, Massachusetts General Hospital, Boston; ²Transplantation Biology Research Center, Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston; ³Plastic and Reconstructive Surgery, Countess of Chester Hospital, Chester, United Kingdom.
Successful application of skin-containing vascularized composite allografts (VCA) depends on accurate assessment of the graft status typically based on skin biopsies. A working classification (Banff…
2015 American Transplant Congress
De Novo DSA Would Not Necessarily Cause Graft Rejection After Renal Transplantation: Characteristics of DSA Developing Biopsy-Proven Chronic Antibody-Mediated Rejection
T. Yamamoto, Y. Watarai, A. Takeda, M. Okada, M. Tsujita, H. Takahisa, N. Goto, S. Narumi, T. Kobayashi.
Kidney Center, Nagoya Daini Red Cross Hospital, Nagoya, Japan.
Introduction:De novo donor-specific HLA antibodies (dn DSA) production after renal transplantation has been reported to be associated with chronic antibody mediated rejection (CAMR), which leads…
2015 American Transplant Congress
A Single Center Study on Pregnacy and Allograf Function Outcomes Post Heart Transplant
S. Adams, M. Wigger.
Heart Transplant, Vanderbilt Medical Center, Nasvhille, TN.
Pregnancy is a special time during a young woman's life, especially more so in those young women who are post heart transplant. The purpose of…
2015 American Transplant Congress
Reduction of Tacrolimus With Everolimus Addition in Maintenance Immunosuppression Improves Calcineurin Inhibitor-Induced Arteriolopathy in Kidney Allografts
M. Miura,¹ H. Higashiyama,¹ Y. Fukasawa.²
¹Department of Renal Transplant Surgery, Sapporo Hokuyu Hospital, Sapporo, Japan; ²Department of Pathology, Sapporo City General Hospital, Sapporo, Japan.
Objectives: Although conversion of calcineurin inhibitor (CNI)-based immunosuppression to everolimus (EVR) has been shown to improve graft function, no histopathological evidence has been reported. The…
2015 American Transplant Congress
Late Antibody-Mediated Rejection in a Large Cross-Sectional Cohort of Kidney Transplant Recipients – Results of the Screening Phase of the BORTEJECT Study
F. Eskandary,¹ G. Bond,¹ H. Regele,² N. Kozakowski,² Z. Kikic,¹ M. Wahrmann,¹ H. Haslacher,³ R. Oberbauer,¹ V. Ramassar,⁴ P. Halloran,⁴ G. Böhmig.¹
¹Nephrology and Dialysis, Medical University Vienna, Vienna, Austria; ²Clinical Institute of Pathology, Medical University Vienna, Vienna, Austria; ³Department of Laboratory Medicine, Medical University Vienna, Vienna, Austria; ⁴4Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Antibody-mediated rejection (ABMR) is well established to be a leading cause of graft failure. Here, we investigated the prevalence of late ABMR in a large…
2015 American Transplant Congress
Mitochondrial Feedback Mechanisms in Kidney Cell Senescence
K. De Vusser,¹ K. Hochstenbach,² E. Winckelmans,² E. Lerut,³ D. Kuypers,¹ T. Nawrot,² M. Naesens.¹
¹Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium; ²Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium; ³Department of Pathology, University Hospitals Leuven, Leuven, Belgium.
BackgroundProgressive DNA damage (telomere attrition) is considered one of the key instigators of ageing. Different models for ageing where DNA damage leads to accelerated senescence…
2015 American Transplant Congress
Prognostic Relevance of Rejection Episodes Detected Within the First 3 Weeks After Kidney Transplantation
V. Arelin,¹ H. Schrem,² F. Lehner,² W. Gwinner,¹ H. Haller,¹ M. Schiffer.¹
¹Division of Nephrology and Hypertension, Department of Medicine, Hannover Medical School, Hannover, Lower Saxony, Germany; ²General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Lower Saxony, Germany.
Background:The relevance of cellular rejection events detected in the early phase after kidney transplantation for graft survival and function remains to be elucidated. Especially the…
2015 American Transplant Congress
Distinct Blood and Biopsy Meta-Signatures for Acute Rejection Post Kidney Transplant
W. Zhang,¹ Z. Yi,¹ Z. Li,¹ M. Menon,¹ L. Li,¹ C. Xi,¹ I. Greene,¹ C. Wei,¹ L. Gallon,² M. Samaniego,³ A. Djamali,⁴ S. Alexander,⁵ B. Schroppel,¹ B. Nankivell,⁵ J. Chapman,⁵ I. Rosales,⁶ R. Neal Smith,⁶ R. Colvin,⁶ P. O'Connell,⁵ P. Heeger,¹ B. Murphy.¹
¹Icahn School of Medicine at Mount Sinai, New York; ²North Western University, Chicago; ³University of Michigan, Michigan; ⁴University of Wisconsin, Madison; ⁵The University of Sydney, Sydney, Austria; ⁶Massachusetts General Hospital, Boston.
Acute rejection (AR) is a major cause of allograft dysfunction. Molecular signatures of AR from blood and biopsy have been identified by several independent cohort…