Articles tagged "Biopsy"

2016 American Transplant Congress
Interaction Between Kidney Tissue Proteome and Humoral Immunity in Antibody Mediated Rejection.
A. Konvalinka,¹ A. Chruscinski,² S. Kim,¹ K. Tinckam,¹ I. Jurisica,³ R. John.⁴
¹Medicine/Division of Nephrology, Toronto General Hospital, Toronto, ON, Canada; ²Medicine/Division of Cardiology, Toronto General Hospital, Toronto, ON, Canada; ³Medical Biophysics and Computational Science, University of Toronto, Toronto, ON, Canada; ⁴Pathology, Toronto General Hospital, Toronto, ON, Canada.
PURPOSE: Antibody-mediated rejection (AMR) is caused by antibodies against human leukocyte antigens (HLA) on graft endothelium, and non-HLA antibodies that target endothelial and epithelial proteins.…
2016 American Transplant Congress
Role of Natural Killer Cells in Kidney Transplant Outcome.
E. Carta,¹ R. Littera,² M. Murgia,¹ M. Michittu,¹ B. Onano,¹ G. Piredda,¹ D. Argiolas.¹
¹Renal Transplant Unit, Azienda Brotzu, Cagliari, Italy; ²Regional Transplant Coordination, ASL 8, Cagliari, Italy.
Aim of the study was to evaluate the relationship between killer cell immunoglobulin-like receptor (KIR) phenotype and kidney transplant rejection. NK-target cell interaction depends on…
2016 American Transplant Congress
Microarray Analysis of Transbronchial and Mucosal Biopsies in Lung Transplant Recipients Detects Molecular Changes of T-Cell Mediated Inflammation.
K. Halloran,¹ J. Chang,² V. Ramassar,² J. Weinkauf,¹ A. Kapasi,¹ D. Lien,¹ J. Reeve,² P. Halloran.^1,2
¹Medicine, University of Alberta, Edmonton, Canada; ²Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, Canada.
Purpose: The main diagnostic platform for rejection in lung transplant recipients is histology of transbronchial biopsies (TBB), a test with a poor performance and safety…
2016 American Transplant Congress
Criteria for the Diagnosis of Microvascular Inflammation (MVI) in Kidney Transplant Biopsies (KTxBx).
J. Grande,¹ R. Leduc,² The DeKAF Study Group.
¹Dept. of Lab Medicine & Pathology, Mayo Clinic College of Medicine, Rochester, MN; ²Division of Biostatistics, U. Minnesota School of Public Health, Minneapolis, MN.
The presence of MVI (Banff glomerulitis "g" score and Banff peritubular capillary "ptc" score) in KTxBx, often related to antibody mediated rejection (AMR), is associated…
2016 American Transplant Congress
Results of Biopsies in Pancreas and Kidney-Pancreas Patients with Graft Dysfunction.
P. Uva, L. Leon, E. Minue, I. Cabrera, A. Giunippero, M. Norese, M. Toniolo, E. Chuluyan, D. Casadei.
Nephrology, Buenos Aires, Argentina.
In pancreas transplantation there is no reliable laboratory test or imaging study for detection of graft rejection. There is an increasing interest in obtaining pancreas…
2016 American Transplant Congress
Management and Outcomes of Upper Extremity Deep Venous Thrombosis in Heart Transplant Patients.
A. Panakos,¹ D. Kramer,¹ M. McCarey,¹ P. Mather.²
¹Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA; ²Cardiology, Thomas Jefferson University Hospital, Philadelphia, PA.
Upper extremity deep venous thrombosis (UEDVT) is common in post-heart transplant (OHT) patients, likely due to their multiple intravascular catheters and post-surgical state. The clinical…
2016 American Transplant Congress
Comparison of C4d Deposition in Renal Biopsies with Luminex-Based C3d Single Antigen Bead (SAB) Detection.
R. Pelletier,¹ I. Balazs,² P. Adams,³ P. Steller,³ N. DiPaola,⁴ L. Rankin,³ A. Diez,⁵ M. Henry.¹
¹Surgery/Transplant, The Ohio State University Wexner Medical Center, Columbus, OH; ²Discovery Research, Immucor, Inc, Stamford, CT; ³Tissue Typing, The Ohio State University Wexner Medical Center, Columbus, OH; ⁴Methodist Hospital, Houston, TX; ⁵Nephrology, The Ohio State University Wexner Medical Center, Columbus, OH.
Recent interest in characterizing the complement-fixing ability of post-transplant donor specific alloantibodies (DSA) resulted in the enhancement of luminex solid phase alloantibody assays to determine…
2016 American Transplant Congress
Age-Based High GFR Associates with Clinical Risk Among Potential Living Donors, but Only with Increased Nephron Number Among Approved Donors.
H. Chakkera,¹ E. Poggio,³ A. Denic,² J. Mathew,² W. Kremers,² J. Larson,² H. Amer,² F. Cosio,² M. Stegall,² S. Taler,² A. Rule.²
¹Mayo Clinic, Arizona; ²Mayo Clinic, Rochester; ³Cleveland Clinic, OH.
Background:Association of high GFR with clinical and kidney structural characteristics among living donors has not been studied.Methods: Study cohort:potential kidney donors evaluated at Mayo Clinic…
2016 American Transplant Congress
Glomerular Capillary C4d Staining without Evidence of Rejection Is Associated with Worse Graft Function in ABO-Incompatible Kidney Transplantation.
D. Toki,¹ M. Inui,¹ M. Okumi,² H. Ishida,² K. Setoguchi,¹ T. Shimizu,² K. Unagami,² K. Tanabe.²
¹Urology, Tokyo Women's Medical University Yachiyo Medical Center, Chiba, Japan; ²Urology, Tokyo Women's Medical University, Tokyo, Japan.
Objectives: C4d staining in the peritubular capillaries (C4d-PTC) is often observed without evidence of rejection in ABO-incompatible kidney transplantation (ABOI-KTx), and this phenomenon is generally…
2016 American Transplant Congress
Long-Term Death-Censored Graft Loss in the DeKAF Study.
A. Matas,¹ A. Fieberg,¹ R. Leduc,¹ F. Cosio,² R. Gaston,³ R. Mannon,³ M. Cecka,⁴ D. Rush,⁷ B. Kasiske,⁵ S. Gourishankar,⁶ J. Connett,¹ J. Grande.²
¹U of MN, Mpls, MN; ²Mayo, Rochester, MN; ³UAB, Birmingham, AB; ⁴UCLA, LA, CA; ⁵HCMC, Mpls, MN; ⁶U Alberta, Edmonton, AB, Canada; ⁷UMB, Winnipeg, MB, Canada.
The aim of the Deterioration of Kidney Allograft Function study (DeKAF) was to identify and assess the pathologies of troubled kidney grafts, that is, those…