ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Biopsy"

  • 2017 American Transplant Congress

    Molecular Analysis of Acute Rejection in Formalin-Fixed Paraffin-Embedded Clinical Face Transplant Biopsies.

    T. Win,1 B. Dyring-Andersen,1 V. Barrera,2 S. Ho Sui,2 R. Lopdrup,1 H. Kiwanuka,1 N. Murakami,1 J. Teague,1 E. Lowry,1 E. Bueno,1 A. Chandraker,1 L. Riella,1 B. Pomahac,1 R. Clark.1

    1Brigham and Women's Hospital, Boston, MA; 2Harvard T.H. Chan School of Publich Health, Boston

    BackgroundDiagnosis of acute rejection in face transplants relies on the histological evaluation of allograft skin biopsies using BANFF classification, an approach with significant limitations including…
  • 2017 American Transplant Congress

    Development of Transplant Glomerulopathy in Recipients with Antibody Mediated Rejection: Activation of Inflammatory Pathway Through Renal Poly (ADP-Ribose) Polymerase (PARP).

    B. Ozdemir,1 F. Ozdemir,2 E. Baskin,2 M. Haberal.3

    1Pathology, Baskent University, Ankara, Turkey; 2Pediatric Nephrology, Baskent University, Ankara, Turkey; 3Transplant Surgery, Baskent University, Ankara, Turkey

    Activation of PARP is a critical factor in the pathogenesis of various inflammatory and fibrotic process. Thus we aimed to show the integral of PARP…
  • 2017 American Transplant Congress

    Outcomes for Plasma Cell Rich Rejection in Pediatric Kidney Transplant Patients.

    O. Moussa, S. Self, K. Twombley.

    Medical University of South Carolina, Charleston

    Introduction and Objective:Plasma cell rich rejection (PCR) has historically been associated with poor outcomes, but there has been minimal data published to date on pediatric…
  • 2017 American Transplant Congress

    Endoscopic Ultrasound Guided Biopsy Sampling of the Pancreas Transplant- The Future of Graft Surveillance?

    E. Nordheim,1 V. Paulsen,2 A. Lars,2 R. Horneland,3 K. Brabrand,4 A. Hartmann,1 T. Jenssen.1,5

    1Section of Nephrology, Department of Transplantation, Oslo University Hospital, Oslo, Norway; 2Section of Gastroenterology, Department of Transplantation, Oslo University Hospital, Oslo, Norway; 3Department of Transplantation, Oslo University Hospital, Oslo, Norway; 4Department of Radiology, Oslo University Hospital, Oslo, Norway; 5Metabolic and Renal Research Group, The Arctic University of Norway, Tromsø, Norway

    Background:Pancreas transplantation (PTX) can improve morbidity and potentially increase survival in selected patients with brittle diabetes. Development of a successful and safe biopsy monitoring program…
  • 2017 American Transplant Congress

    Molecular Significance of Peritubular Capillaritis in Early Transplant Kidney Biopsies of Donor-Specific Antibody Negative Patients.

    M. Ajaimy, P. O Broin, Y. Bao, E. Akalin.

    Montefiore Medical Center Transplant Center, Albert Einstein College of Medicine, Bronx

    Background: Peritubular capillaritis (PTC) is a part of microvascular inflammation seen in antibody-mediated rejection. However, it can be observed as an isolated lesion in early…
  • 2017 American Transplant Congress

    Prospective DSA Monitoring and Significance of De Novo DSA in Adult Liver Transplantation.

    S. Kubal,1 R. Mangus,1 J. Fridell,1 B. Ekser,1 R. Saxena,2 N. Rush,2 N. Higgins,4 M. Ghabril,3 M. Lacerda,3 A. Lobashevsky.4

    1Department of Surgery, Division of Transplantation, Indiana University School of Medicine, Indianapolis, IN; 2Department of Pathology, Indiana University School of Medicine, Indianapolis, IN; 3Department of Gastroenterology, Division of Hepatology, Indiana University School of Medicine, Indianapolis, IN; 4Department of Medicine, Immunology/Histocompatibility Laboratory, Indiana University School of Medicine, Indianapolis, IN

    Background: Post transplant course of circulating de novo donor specific antibodies (DSA) remains unknown after liver transplantation (LT).Methods: In a prospective study, sera from 92…
  • 2017 American Transplant Congress

    Ectopic Lymphoid Structures Are Present in Type I T-Cell Mediated Kidney Transplant Rejection.

    K. de Leur,1,2 M. Clahsen-van Groningen,3 G. de Graav,1 D. Hesselink,1 J. Samsom,4 C. Baan,1 K. Boer.1

    1Internal Medicine, Erasmus MC, Rotterdam, Netherlands; 2Surgery, Division HPB and Transplant Surgery, Erasmus MC, Rotterdam, Netherlands; 3Pathology, Erasmus MC, Rotterdam, Netherlands; 4Pediatrics, Erasmus MC, Rotterdam, Netherlands

    BackgroundIn renal transplantation, many allograft recipients develop donor-specific antibodies associated with an increased risk for graft rejection. Current immunosuppressive agents are principally aimed at T-cell-mediated…
  • 2017 American Transplant Congress

    C1q+ and IgG3+ De Novo Donor Specific Antibody Are Associated with Allograft Failure in a Multicenter Cohort.

    C. Schinstock,1 M. Everly,2 M. Samaniego,3 M. Gandhi,1 R. Parikh,4 V. Sharma,4 M. Stegall,1 D. Dadhania.4

    1Mayo Clinic, Rochester, MN; 2Terasaki Research Institute, Los Angelos, CA; 3University of Michigan, Ann Arbor, Mi; 4Cornell University, New York, NY

    Introduction: De novo donor specific antibody (dnDSA) is a risk factor for antibody mediated rejection and allograft loss, but dnDSA does not always lead to…
  • 2017 American Transplant Congress

    Biomarkers of Epithelial-Mesenchymal Transition (EMT) in Chronic Allograft Nephropathy: Potential for Early Detection and Development of Novel Therapeutic Agents.

    S. Kanangat, R. Miller, S. Rezaeian, H. Eldib, D. Cimbaluk, C. Fhied, I. Kurbegovic-Skaljic, M. Prod, J. Borgia, M. Flaws, D. Castillo, R. DeCresce.

    Pathology, BioChemistry and Medical Laboratory Sciences, Rush University Medical Center, Chicago, IL

    Purpose: To detect markers and novel treatment targets related to fibrogenesis and eventual graft loss by focusing on Epithelial Mesenchymal transition (EMT) which requires understanding…
  • 2017 American Transplant Congress

    Clinical Correlation of Endomyocardial Biopsies Molecular Profiling: Taking Rejection Diagnosis Beyond Histology.

    L. Potena,1 L. Borgese,1 A. Gaudenzi,1 V. Agostini,1 J. Reeve,2 M. Masetti,1 F. Grigioni,1 O. Leone,1 P. Halloran.

    1University of Bologna, Bologna, Italy; 2Alberta Transplant Applied Genomics Centre, Edmonton, Canada

    Histology grading of endomyocardial biopsies (EMB), the standard for diagnosing T-cell-mediated (TCMR) and antibody-mediated (ABMR) rejection, has serious issues with reproducibility (Transplantation 94 (11):1172177, 2012)…
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