2017 American Transplant Congress
Ectopic Lymphoid Structures Are Present in Type I T-Cell Mediated Kidney Transplant Rejection.
BackgroundIn renal transplantation, many allograft recipients develop donor-specific antibodies associated with an increased risk for graft rejection. Current immunosuppressive agents are principally aimed at T-cell-mediated…2017 American Transplant Congress
Characterization of De Novo Donor-Specific HLA Antibodies and Correlations with C4d+ Antibody-Mediated Rejection of Kidney Transplants.
Aim: Characteristics of de novo donor-specific HLA antibodies (dnDSA) that are associated with C4d positive antibody-mediated rejection (C4d+ AMR) in kidney transplants have not been…2017 American Transplant Congress
Use of Forensic DNA Testing to Trace Unethical Organ Procurement and Organ Trafficking Practices.
The purpose of this study is to establish a methodology, which allows to identify evidence of transplant organs originating from Falun Gong prisoners of conscience…2017 American Transplant Congress
Clinical Correlation of Endomyocardial Biopsies Molecular Profiling: Taking Rejection Diagnosis Beyond Histology.
Histology grading of endomyocardial biopsies (EMB), the standard for diagnosing T-cell-mediated (TCMR) and antibody-mediated (ABMR) rejection, has serious issues with reproducibility (Transplantation 94 (11):1172177, 2012)…2017 American Transplant Congress
Biopsies (Bx) of Renal Allografts with Antibody- + Cell-Mediated Rejection (ABMR/CMR) Exhibit Gene Expression Signatures from Both Types of Rejection.
Background: In HLA-sensitized kidney transplant patients (Pts) the concomitant presence of ABMR/CMR on Bx is associated with a more severe and (&) usually irreversible injury…2017 American Transplant Congress
The Molecular Phenotypes of Rejection in Kidney Transplant Biopsies.
University of Alberta, Edmonton, AB, Canada
In a microarray analysis of 1208 kidney transplant indication biopsies, each biopsy was assigned molecular scores for seven phenotypes related to various aspects of TCMR,…2017 American Transplant Congress
Long-Term Immunosuppression Adherence After Kidney Transplant and Relationship to Allograft Histology.
Background: Loss of Medicare coverage for immunosuppression 3 years after kidney transplant may be associated with increased nonadherence. The goal of this study was to…2017 American Transplant Congress
C5b-9 Deposition in Glomerular Capillaries Is Responsible for Poor Allograft Survival in Antibody-Mediated Rejection.
1University Hospital, Montpellier, France; 2Cancer Research Institute, Montpellier, France
Introduction: C4d (scare of C4 cleavage) deposition in peritubular capillaries (PTC), a marker of complement activation, is associated with antibody-mediated rejection (AMR) in kidney transplantation.…2017 American Transplant Congress
Utility of Electron Microscopy in Kidney Transplant Biopsies.
1LSUHSC, New Orleans, LA; 2Children's Hospital, New Orleans, LA
Background: Banff 2013 criteria recommends performing ultra-structural studies with electron microscopy (EM) in most kidney transplant (KT) biopsies if the technology is available. We aimed…2017 American Transplant Congress
Procurement Kidney Biopsy versus KDRI for Predicting Graft Survival.
Background: The kidney donor risk index (KDRI) incorporates 10 variables to match organ quality with expected recipient survival. Though controversial, procurement biopsies are often performed…
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