ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Biopsy"

  • 2019 American Transplant Congress

    Recipient Antibiotics Pretreatment Protects Liver Transplants from Ischemia-Reperfusion Injury via Prostaglandin E2: From Bench-to Bedside

    K. Nakamura, S. Kageyama, T. Ito, H. Hirao, K. Kadono, K. J. Dery, J. Aziz, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski

    Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA

    *Purpose: We and others have reported on benefits of endoplasmic reticulum (ER) stress modulation and autophagy enhancement to mitigate ischemia-reperfusion injury (IRI) in orthotopic liver…
  • 2019 American Transplant Congress

    Timing and Donor-Specific Antibodies, but Not C4d Deposition, Determine Leukocyte Infiltration in Renal Allograft Biopsies with the Histological Picture of Antibody-Mediated Rejection

    J. Callemeyn1, A. Senev1, E. Lerut2, M. Coemans1, D. Kuypers1, W. Gwinner3, M. Essig4, D. Anglicheau5, P. Marquet6, M. Naesens1

    1Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium, 2Department of Pathology, University Hospitals Leuven, Leuven, Belgium, 3Department of Nephrology, Hannover Medical School, Hannover, Germany, 4Department of Nephrology, Dialysis and Transplantation, University of Limoges, Limoges, France, 5Necker-Enfants Malades Institute, French National Institute of Health and Medical Research U1151, Paris, France, 6U850 INSERM, University of Limoges, Limoges, France

    *Purpose: Diagnosis of antibody-mediated rejection following kidney transplantation can be challenging, given the limited specificity of individual histological parameters and time-dependent occurrence of histological confounders.…
  • 2019 American Transplant Congress

    Incidence and Predictors of Post-Kidney Biopsy (KBx) Bleeding in Liver Transplant (LT) Candidates with Renal Dysfunction

    H. M. Wadei1, P. Abader1, N. Aslam2, T. Jarmi1, A. P. Keaveny1, K. Croome1, D. D. Lee1, C. Taner1

    1Department of Transplant, Mayo Clinic, Jacksonville, FL, 2Department of Medicine, Division of Nephrology, Mayo Clinic, Jacksonville, FL

    *Purpose: Pre-LT kidney biopsy is seldom performed in LT candidates with renal dysfunction and/or proteinuria partially due to the limited information regarding KBx bleeding. We…
  • 2019 American Transplant Congress

    Recipient TIM4 Expression is Essential for Hepatocellular Function in Liver Transplantation

    K. Kadono, S. Kageyama, H. Hirao, K. Nakamura, K. J. Dery, D. Oncel, T. Ito, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski

    Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA

    *Purpose: Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and predisposes to rejection in orthotopic liver transplantation (OLT). Previous studies…
  • 2019 American Transplant Congress

    Microsteatosis in Livers from Donation after Circulatory Death (DCD) Donors is Associated with Inferior Graft and Patient Survival Following Liver Transplantation (LTX)

    N. Bath, G. Leverson, D. Foley

    University of Wisconsin, Madison, WI

    *Purpose: The current theory is that severe macrosteatosis (MaS) (>50%) in livers recovered from donation after brain death (DBD) donors leads to increased rates of…
  • 2019 American Transplant Congress

    Comparing Antibody-Mediated Rejection with or without Detectable DSA: Similar Pathology and Similar Poor Prognosis

    G. Einecke1, J. Reeve2, P. F. Halloran3

    1Dpt. of Nephrology, Hannover Medical School, Hannover, Germany, 2Dpt. of Laboratory Medicine and Pathology and Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada, 3Dpt. of Nephrology and Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada

    *Purpose: Banff guidelines require the detection of donor-specific antibodies (DSA) in addition to microvascular inflammation (MVI) for a diagnosis of antibody-mediated rejection (ABMR), but MVI…
  • 2019 American Transplant Congress

    Replication of Diagnostic Biomarkers Using Orthogonal State-of-the-Art Technologies

    M. Cassidy, B. Dooley, A. Verma, H. Yang, T. Muthukumar, R. Ding, C. Li, C. Snopkowski, B. Botticelli, S. Albakry, E. Edusei, M. Lubetzky, D. Dadhania, J. Lee, O. Elemento, M. Suthanthiran

    WCM, New York, NY

    *Purpose: The failure to reproduce scientific findings (McNutt M. Science 2014;343:229, Baker M. Nature 2016;53:452) has brought to the forefront the need for replication studies…
  • 2019 American Transplant Congress

    Trimming the Fat?: Optimizing Utilization of Liver Allografts with Macrosteatosis >30% in Recipients with MELD Scores <35

    J. A. Steggerda1, M. B. Bloom1, T. Todo2, T. V. Brennan2, N. N. Nissen2, A. S. Klein2, I. K. Kim2

    1Surgery, Cedars-Sinai Medical Center, Los Angeles, Los Angeles, CA, 2Transplant Surgery, Cedars-Sinai Medical Center, Los Angeles, Los Angeles, CA

    *Purpose: Macrosteatosis (MaS) >30% in liver allografts has been associated with increased risk of primary non-function and poor graft survival. This study assesses the influence…
  • 2019 American Transplant Congress

    Association of Histological Findings in Renal Graft Biopsy with Non-Adherence to Immunosuppressive Treatment

    B. D. Cardoso1, J. Montagner2, K. Pegas3, R. Kist4, J. Neumann5, H. S. Pinheiro6, V. D. Garcia4, E. Keitel1

    1Department of Nephrology and Kidney Transplantation/ Post Graduation Program in Pathology, Irmandade Santa Casa de Misericórdia/ Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil, 2Transplant Immunology Laboratory,, Irmandade Santa Casa de Misericórdia, Porto Alegre, Brazil, 3Department of Pathology, Irmandade Santa Casa de Misericórdia, Porto Alegre, Brazil, 4Department of Nephrology and Kidney Transplantation, Irmandade Santa Casa de Misericórdia, Porto Alegre, Brazil, 5Transplant Immunology Laboratory, Irmandade Santa Casa de Misericórdia, Porto Alegre, Brazil, 6Renal Transplant Unit, NIEPEN/NIDEAL (UFJF), Porto Alegre, Brazil

    *Purpose: Non-adherence to immunosuppressive treatment after renal transplantation is a frequent issue, but the magnitude of its impact has been debated. It is unknown whether…
  • 2019 American Transplant Congress

    Correlation between Gene Expression and Histology in Transbronchial Lung Transplant Biopsies

    B. Adam, K. Du, S. Rotich, M. Mengel

    University of Alberta, Edmonton, AB, Canada

    *Purpose: Transbronchial lung transplant biopsies (TBBx) are limited by non-specific histologic lesions and suboptimal interobserver reproducibility. Gene expression offers a potentially more precise, objective and…
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