Articles tagged "Biopsy"

2019 American Transplant Congress
Recipient TIM4 Expression is Essential for Hepatocellular Function in Liver Transplantation
K. Kadono, S. Kageyama, H. Hirao, K. Nakamura, K. J. Dery, D. Oncel, T. Ito, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski
Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and predisposes to rejection in orthotopic liver transplantation (OLT). Previous studies…
2019 American Transplant Congress
Microsteatosis in Livers from Donation after Circulatory Death (DCD) Donors is Associated with Inferior Graft and Patient Survival Following Liver Transplantation (LTX)
N. Bath, G. Leverson, D. Foley
University of Wisconsin, Madison, WI
*Purpose: The current theory is that severe macrosteatosis (MaS) (>50%) in livers recovered from donation after brain death (DBD) donors leads to increased rates of…
2019 American Transplant Congress
Comparing Antibody-Mediated Rejection with or without Detectable DSA: Similar Pathology and Similar Poor Prognosis
G. Einecke¹, J. Reeve², P. F. Halloran³
¹Dpt. of Nephrology, Hannover Medical School, Hannover, Germany, ²Dpt. of Laboratory Medicine and Pathology and Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada, ³Dpt. of Nephrology and Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada
*Purpose: Banff guidelines require the detection of donor-specific antibodies (DSA) in addition to microvascular inflammation (MVI) for a diagnosis of antibody-mediated rejection (ABMR), but MVI…
2019 American Transplant Congress
Replication of Diagnostic Biomarkers Using Orthogonal State-of-the-Art Technologies
M. Cassidy, B. Dooley, A. Verma, H. Yang, T. Muthukumar, R. Ding, C. Li, C. Snopkowski, B. Botticelli, S. Albakry, E. Edusei, M. Lubetzky, D. Dadhania, J. Lee, O. Elemento, M. Suthanthiran
WCM, New York, NY
*Purpose: The failure to reproduce scientific findings (McNutt M. Science 2014;343:229, Baker M. Nature 2016;53:452) has brought to the forefront the need for replication studies…
2019 American Transplant Congress
Trimming the Fat?: Optimizing Utilization of Liver Allografts with Macrosteatosis >30% in Recipients with MELD Scores <35
J. A. Steggerda¹, M. B. Bloom¹, T. Todo², T. V. Brennan², N. N. Nissen², A. S. Klein², I. K. Kim²
¹Surgery, Cedars-Sinai Medical Center, Los Angeles, Los Angeles, CA, ²Transplant Surgery, Cedars-Sinai Medical Center, Los Angeles, Los Angeles, CA
*Purpose: Macrosteatosis (MaS) >30% in liver allografts has been associated with increased risk of primary non-function and poor graft survival. This study assesses the influence…
2019 American Transplant Congress
Association of Histological Findings in Renal Graft Biopsy with Non-Adherence to Immunosuppressive Treatment
B. D. Cardoso¹, J. Montagner², K. Pegas³, R. Kist⁴, J. Neumann⁵, H. S. Pinheiro⁶, V. D. Garcia⁴, E. Keitel¹
¹Department of Nephrology and Kidney Transplantation/ Post Graduation Program in Pathology, Irmandade Santa Casa de Misericórdia/ Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil, ²Transplant Immunology Laboratory,, Irmandade Santa Casa de Misericórdia, Porto Alegre, Brazil, ³Department of Pathology, Irmandade Santa Casa de Misericórdia, Porto Alegre, Brazil, ⁴Department of Nephrology and Kidney Transplantation, Irmandade Santa Casa de Misericórdia, Porto Alegre, Brazil, ⁵Transplant Immunology Laboratory, Irmandade Santa Casa de Misericórdia, Porto Alegre, Brazil, ⁶Renal Transplant Unit, NIEPEN/NIDEAL (UFJF), Porto Alegre, Brazil
*Purpose: Non-adherence to immunosuppressive treatment after renal transplantation is a frequent issue, but the magnitude of its impact has been debated. It is unknown whether…
2019 American Transplant Congress
Correlation between Gene Expression and Histology in Transbronchial Lung Transplant Biopsies
B. Adam, K. Du, S. Rotich, M. Mengel
University of Alberta, Edmonton, AB, Canada
*Purpose: Transbronchial lung transplant biopsies (TBBx) are limited by non-specific histologic lesions and suboptimal interobserver reproducibility. Gene expression offers a potentially more precise, objective and…
2019 American Transplant Congress
Digital Imaging Software vs. the “Eyeball” Method in Quantifying Steatosis in a Liver Biopsy
J. Long¹, J. Motter¹, S. Besharati¹, S. Jerman², R. Anders¹, A. Ortiz², D. Bowman², T. Dunn³, D. Lee⁴, A. Massie¹, R. Barth⁵, B. Philosophe¹
¹Johns Hopkins, Baltimore, MD, ²Indica Labs, Corrales, NM, ³UPenn, Philadelphia, PA, ⁴Mayo Clinic, Jacksonville, FL, ⁵University of MD, Baltimore, MD
*Purpose: The use of steatotic livers is controversial, but may represent an underutilized resource to increase the donor pool. Although
2019 American Transplant Congress
Comparison with Solid Organ Transplants Reveals Distinct Face Transplant Rejection Gene Signature That Reflects the Unique Immunobiology of Skin
T. Win, B. Dyring-Andersen, R. Lopdrup, J. Teague, N. Murakami, A. Chandraker, S. G. Tullius, B. Pomahac, L. V. Riella, R. A. Clark
Brigham and Women's Hospital, Boston, MA
*Purpose: Skin containing transplants, such as face transplants, are immunologically unique. We compared the gene expression profiles of acute cellular rejection in human face transplants…
2019 American Transplant Congress
The Molecular Profile of Kidney Allografts Unveil Specific Biomarkers for Subclinical Acute Rejection (SAR). Towards an Early Detection and a Targeted Treatment
S. N. Cox, S. Chiurlia, F. P. Schena
Schena Foundation, Valenzano-Bari, Italy
*Purpose: SAR diagnosed by protocol biopsy is an independent risk factor for chronic allograft injury. We organized a molecular study on 24 AB0 compatible cadaveric…