Articles tagged "Bioengineering"

2021 American Transplant Congress
Development of a Lateral Flow Assay Detecting CXCL9 within Antibody Mediated and Acute T Cell Mediated Rejections After Kidney Transplantation
L. K. Seiler¹, R. Jonczyk¹, P. Lindner¹, L. Phung¹, C. Falk², C. Blume¹
¹Faculty of Natural Sciences, Institute of Technical Chemistry, Hannover, Germany, ²Institute of Transplant Immunology, Medical School Hannover, Hannover, Germany
*Purpose: Despite tremendous improvements in quality and tolerability of immunosuppressive medications after successful kidney transplantation, numerous kidney grafts undergo acute and chronic rejections with following…
2020 American Transplant Congress
Recruitment of Regulatory T Cells Promotes Donor-Specific Tolerance in Vascularized Composite Allotransplantation
J. D. Fisher¹, W. Zhang², S. C. Balmert³, A. M. Aral¹, Y. Kulahci⁴, A. P. Acharya⁴, J. Li², H. R. Turnquist⁵, A. W. Thomson⁵, M. G. Solari², V. S. Gorantla⁶, S. R. Little⁴
¹Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, ²Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, ³Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, ⁴Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, ⁵Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, ⁶Department of Bioengineering, Wake Forest University, Winston-Salem, NC
*Purpose: Vascularized composite allotransplantation (VCA) encompasses face and limb transplantation, but as with organ transplantation, it requires lifelong regimens of immunosuppressive drugs to prevent rejection.*Methods:…
2020 American Transplant Congress
Concept Discussion: Five Experimental Stages to Establish the Methodologies for Organ Farming
R. F. Smith
George Washington University, Bristow, VA
*Purpose: Most of the technologies to grow human organs in vitro already exist, but experimentation (and policy development support) will be required to ensure that:*Methods:…
2020 American Transplant Congress
New Strategy to Maximize Nanomedicine Delivery During Ex Vivo Organ Perfusion
C. Albert¹, L. Bracaglia¹, A. Koide², C. M. Edwards³, T. Lysyy³, J. S. Pober⁴, M. Saltzman¹, S. Koide², G. Tietjen³
¹Biomedical Engineering, Yale University, New Haven, CT, ²Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, ³Surgery, Yale University, New Haven, CT, ⁴Immunobiology, Yale University, New Haven, CT
*Purpose: Organ transplant is a highly successful therapy for patients facing end stage organ failure. However, there is a severe lack of transplantable organs which…
2020 American Transplant Congress
3D Bioprinted Intrahepatic Cholangiocarcinoma Model and 7-Day Perfusion with Gemcitabine and Cisplatin: Modeling the Tumor Microenvironment and Response to Chemotherapy
A. M. Chen¹, W. Zhang¹, J. Sterner², L. Kennedy³, A. Isidan¹, E. Gramelspacher¹, H. L. Francis³, G. Alpini³, L. J. Smith², P. Li¹, B. Ekser¹
¹Division of Transplant Surgery - Indiana University, Indianapolis, IN, ²3D Bioprinting Core and Department of Radiology and Imaging Sciences - Indiana University, Indianapolis, IN, ³Division of Gastroenterology, Richard L. Roudebush VA Medical Center and Indiana University, Indianapolis, IN
*Purpose: Over 8,000 patients are newly diagnosed with cholangiocarcinoma (CCA) in the United States each year.Understanding the CCA microenvironment will facilitate the development of novel…
2020 American Transplant Congress
Regulatory T Cells Engineered with TCR-Signaling-Responsive Il-2 Nanogels Suppress Alloimmunity in Sites of Antigen Encounter
S. K. Eskandari¹, J. B. Alhaddad¹, I. Sulkaj², M. B. Melo², N. Li², H. Allos¹, B. Kollar¹, M. A. Seelen³, D. J. Irvine⁴, J. Azzi¹
¹Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Koch Institute for Integrative Cancer Research, Massachusetts Insitute of Technology, Cambridge, MA, ³Nephrology, University Medical Center Groningen, Groningen, Netherlands, ⁴Medicine, Koch Institute for Integrative Cancer Research, Massachusetts Insitute of Technology, Cambridge, MA
*Purpose:
2020 American Transplant Congress
Tonic-Signaling Chimeric Antigen Receptors Drive Exhaustion in Regulatory T Cells
C. Lamarche¹, C. Mackall², E. Weber³, M. Levings⁴
¹University of British Columbia, Vancouver, BC, Canada, ²Stanford University School of Medicine, Standford, CA, ³Stanford University School of Medicine, Stanford, CA, ⁴Surgery, University of British Columbia and BC Children's Hospital Research Institute, Vancouver, BC, Canada
*Purpose: Regulatory T cells (Tregs) and chimeric antigen receptor (CAR) Tregs are a promising cell therapy to prevent or treat autoimmune diseases or allograft rejection.…
2020 American Transplant Congress
Prolonged In Vivo Perfusion of a Re-Endothelialized Human-Scale Tissue Engineered Kidney Graft
J. S. Uzarski¹, E. E. Russell¹, E. C. Beck¹, M. Holzner², V. Wadhera², D. Adamson², T. Gilbert¹, S. Florman², D. S. Davidow¹, R. Shapiro², J. Ross¹
¹Research & Development, Miromatrix Medical Inc., Eden Prairie, MN, ²Recanati/Miller Institute, Mount Sinai, New York, NY
*Purpose: Advances are desperately needed to increase the supply of transplantable kidneys for the 100,000 patients on the waiting list. Whole organ engineering is one…
2020 American Transplant Congress
Real-Time Viability Assessment During Normothermic Machine Perfusion with Resonance Raman Spectroscopy
R. J. De Vries¹, S. Raigani¹, P. Romfh², S. E. Cronin¹, C. A. Pendexter¹, C. Carroll¹, T. M. Van Gulik³, P. Chen², K. Uygun¹, H. Yeh¹, S. N. Tessier¹
¹Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ²Pendar Technologies, Cambridge, MA, ³Surgery, Amsterdam University Medidical Centers, Location AMC, Amsterdam, Netherlands
*Purpose: Viability assessment during normothermic machine perfusion (NMP) continues to lack objective metrics that facilitate accurate clinical decision making, in order to minimize discard rates…
2020 American Transplant Congress
The Impact of Transportation Innovation for Human Organs: Surgical Perspectives and Implications
T. Talaie, S. Niederhaus, E. Villalonga, J. Bromberg, J. Scalea
Transplant Surgery, Unviersity of Maryland Medical Center, Baltimore, MD
*Purpose: Recent changes in allocation and the ongoing organ donor shortage have led to increased regional and national sharing, putting intense pressure on the organ…