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American Transplant Congress abstracts

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Articles tagged "Bioengineering"

  • 2021 American Transplant Congress

    Cross-Circulation for Extracorporeal Liver Support in a Swine Model

    W. K. Wu1, A. Tumen1, J. W. Stokes2, R. Ukita2, A. E. Hozain3, C. R. Flynn2, M. J. Lee3, J. R. Talackine2, N. L. Cardwell2, J. A. Reimer3, M. Pinezich3, C. Benson2, G. Vunjak-Novakovic3, S. P. Alexopoulos2, M. Bacchetta2

    1co-first authors, Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt University Medical Center, Nashville, TN, 3Columbia University Medical Center, New York, NY

    *Purpose: Although machine perfusion has gained momentum as an organ preservation strategy in liver transplantation, significant organ shortages and waitlist mortality persist, highlighting unmet needs…
  • 2020 American Transplant Congress

    Prolonged In Vivo Perfusion of a Re-Endothelialized Human-Scale Tissue Engineered Kidney Graft

    J. S. Uzarski1, E. E. Russell1, E. C. Beck1, M. Holzner2, V. Wadhera2, D. Adamson2, T. Gilbert1, S. Florman2, D. S. Davidow1, R. Shapiro2, J. Ross1

    1Research & Development, Miromatrix Medical Inc., Eden Prairie, MN, 2Recanati/Miller Institute, Mount Sinai, New York, NY

    *Purpose: Advances are desperately needed to increase the supply of transplantable kidneys for the 100,000 patients on the waiting list. Whole organ engineering is one…
  • 2020 American Transplant Congress

    Real-Time Viability Assessment During Normothermic Machine Perfusion with Resonance Raman Spectroscopy

    R. J. De Vries1, S. Raigani1, P. Romfh2, S. E. Cronin1, C. A. Pendexter1, C. Carroll1, T. M. Van Gulik3, P. Chen2, K. Uygun1, H. Yeh1, S. N. Tessier1

    1Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 2Pendar Technologies, Cambridge, MA, 3Surgery, Amsterdam University Medidical Centers, Location AMC, Amsterdam, Netherlands

    *Purpose: Viability assessment during normothermic machine perfusion (NMP) continues to lack objective metrics that facilitate accurate clinical decision making, in order to minimize discard rates…
  • 2020 American Transplant Congress

    The Impact of Transportation Innovation for Human Organs: Surgical Perspectives and Implications

    T. Talaie, S. Niederhaus, E. Villalonga, J. Bromberg, J. Scalea

    Transplant Surgery, Unviersity of Maryland Medical Center, Baltimore, MD

    *Purpose: Recent changes in allocation and the ongoing organ donor shortage have led to increased regional and national sharing, putting intense pressure on the organ…
  • 2020 American Transplant Congress

    A Novel Injectable Hydrogel-Based Approach to Localize and Tune the Actuation of Enhanced Costimulation Blockade to the Strength of Transplant Rejection

    A. Komin1, C. Liang2, P. Majumder2, X. Calderon-Colon3, O. Tiburzi3, M. Iglesias Lozano1, Y. Zhang1, G. Brandacher1, J. Patrone3, J. Schneider2, G. Raimondi1

    1Johns Hopkins School of Medicine, Baltimore, MD, 2NIH National Cancer Institute, Frederick, MD, 3JHU Applied Physics Laboratory, Laurel, MD

    *Purpose: Complications from long-term use of calcineurin inhibitors remain a major issue for transplant patients and alternative therapies are needed. The clinical efficacy of CTLA4-Ig…
  • 2020 American Transplant Congress

    Multimodal Theranostic Nanocolloid Platform for Imaging, Targeted Drug Delivery and Organ Preservation in Transplantation

    J. M. Janjic1, E. Lambert1, L. Liu1, M. Herneisey1, V. S. Gorantla2

    1School of Pharmacy, Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA, 2Wake Forest Institute for Regenerative Medicine, Winston- Salem, NC

    *Purpose: The goal of this project design and development of multifunctional nanomedicines to address unique and complex therapeutic outcomes in transplantation and organ preservation. Presented…
  • 2020 American Transplant Congress

    Development and Cell Surface Testing of a Novel Nanofiber Technology for Targeted Delivery of Therapeutic Regulatory T Cells

    J. M. Mathew1, S. Lee2, Y. Sambandam1, L. A. Fraser2, T. D. Clemons2, A. Kolberg2, J. He1, L. C. Palmer2, M. T. McClendon2, Z. J. Zhang1, J. R. Leventhal1, S. I. Stupp2, L. Gallon1

    1Surgery -Transplant, Northwestern University, Chicago, IL, 2Simpson Querrey Institute, Northwestern University, Chicago, IL

    *Purpose: Regulatory CD4+CD25+FOXP3+ T cells (Tregs) have been shown to induce tolerance in transplantation models, and to be increased in their numbers in tolerant human…
  • 2020 American Transplant Congress

    Building Kidneys from Stem Cells for Transplantation

    I. M. Rogers1, J. Whiteley2, T. Chow2, T. Bongolan2, L. Mazilescu3, P. Urbanellis3, S. Ganesh3, M. Selzner3

    1Physiology, University of Toronto, Toronto, ON, Canada, 2LTRI-Sinai Health System, Toronto, ON, Canada, 3MOTU, University Health Network, Toronto, ON, Canada

    *Purpose: Our vision is to build a human kidney by combining human stem cells with porcine kidney extracellular matrix.*Methods: Kidneys were decellularized followed by repopulation…
  • 2020 American Transplant Congress

    Prolonged Functional Human 3D Liver Organoids as an In Vitro Liver Disease Model

    W. Zhang1, A. Isidan1, A. M. Chen1, L. J. Smith2, H. L. Francis3, G. Alpini3, E. Gramelspacher1, P. Li1, B. Ekser1

    1Division of Transplant Surgery - Indiana University, Indianapolis, IN, 23D Bioprinting Core and Department of Radiology and Imaging Sciences - Indiana University, Indianapolis, IN, 3Division of Gastroenterology, Richard L. Roudebush VA Medical Center and Indiana University, Indianapolis, IN

    *Purpose: Animal models used for evaluating the mechanisms of liver disease do not fully mimic the complex architecture and metabolic functions of the human liver.…
  • 2020 American Transplant Congress

    Formation Of Artificial Blood Vessels Using ECM In 3D Bioprinting

    P. Cywoniuk, T. Bryniarski, T. Dobrzanski, K. Kosowska, M. Klak, G. Tymicki, P. Kowalska, M. Gomolka, P. Turowski, I. Zamora, A. Berman, M. Wszola

    Foundation of Research and Science Development, Warsaw, Poland

    *Purpose: Development of fully functional blood vessels in expanding field of artificial tissues and organs for transplantations in regenerative medicine is fundamental to provide proper…
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