Articles tagged "B cells"

2019 American Transplant Congress
Anti CD45RB Antibody Therapy Attenuates Renal Ischemia Reperfusion Injury by Inducing Regulatory B Cells
S. Lee¹, S. Park¹, J. Hwang¹, J. Ryu², T. Koo², C. Ahn², J. Yang³
¹Biomedical Research Institute, Transplantation Center, Seoul National University Hospital, Seoul, Korea, Republic of, ²Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ³Department of surgery, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Regulatory B cells (Bregs) are a new B cell subset that suppresses immune responses. Recently, both anti-CD45RB and anti-Tim-1 treatments have been found to…
2019 American Transplant Congress
TACI Polymorphisms Associated with Increased Alloimmunity and Allograft Rejection
M. Garcia de Mattos-Barbosa¹, E. A. Farkash², J. L. Platt¹, M. Cascalho¹
¹Transplant Surgery, University of Michigan, Ann Arbor, MI, ²Pathology, University of Michigan, Ann Arbor, MI
*Purpose: Transmembrane activator and CAML interactor (TACI) controls B cell differentiation. The TACI gene is highly polymorphic (>95% of all genes) and frequently variants exhibit…
2019 American Transplant Congress
Epstein Barr Virus DNA Integration in B Cell Lymphomas of Post-Transplant Lymphoproliferative Disorder
M. C. McPherson, O. M. Martinez
Surgery, Division of Abdominal Transplant, Stanford University School of Medicine, Stanford, CA
*Purpose: Epstein Barr virus-positive (EBV+) B cell lymphomas can arise in immunosuppressed individuals, such as organ transplant recipients in the context of post-transplant lymphoproliferative disorder…
2019 American Transplant Congress
Role of MHC Class II in B Cell and Regulatory T Cell Development
S. K. Germana, Z. Wang, C. A. Huang, L. Kojima, C. G. Rickert, J. F. Markmann, C. LeGuern
Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Therapies involving CD4 regulatory T cells (Tregs) are promising approaches to mitigate graft rejection and autoimmunity. Understanding of the activation mechanisms that initiate Treg…
2019 American Transplant Congress
BCMA Expression by Alloreactive B Cells Increases during De Novo Alloantibody Responses
N. Chai, G. Wu, I. Kim, A. Klein, S. Jordan
Comprehensive Transplant Center, Cedars-Sinai Med Ctr, Los Angeles, CA
*Purpose: BCMA(TNFRSF17) belongs to tumor necrosis factor receptor superfamily. It is selectively expressed during B/plasma cell differentiation while being nearly absent on naive and memory…
2019 American Transplant Congress
A Step-Wise Desensitization Using Rituximab&Bortezomib Combined with Antithymocyte Globulin for Highly Sensitized Kidney Transplant Candidates
H. Ohdan, K. Ide, M. Ohira, H. Tahara, Y. Tanaka
Hiroshima University, Hiroshima, Japan
*Purpose: In highly HLA sensitized patients, both memory B and T cells responding to donor-specific HLA in addition to plasma cells secreting anti-HLA Abs are…
2019 American Transplant Congress
Iguratimod Inhibits the Donor Specific Antibodies Production and Attenuates the Antibody Mediated Rejection in Rat Kidney Transplantation
Z. Wang, M. Zheng, H. Chen, S. Li, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: Our study was designed to investigate the efficacy and related mechanisms of Iguratimod (T-614) in the inhibition of DSAs following kidney transplantation.*Methods: A rat…
2019 American Transplant Congress
Treg-Lymphatic Crosstalk: Lymphotoxin Signals as Modulators of Immunity and Suppression
W. Piao¹, L. Li², V. Saxena², Y. Xiong², C. Paluskievicz², J. Bromberg³
¹Microbiology and Immunology, U. Maryland, Baltimore, baltimore, MD, ²Surgery, U. Maryland, Baltimore, Baltimore, MD, ³Surgery and Microbiology and Immunology, U. Maryland, Baltimore, Baltimore, MD
*Purpose: Little is known about the molecular cues that regulate the entry of leukocytes across lymphatic vessels. Regulatory T cells (Treg) express high amounts of…
2019 American Transplant Congress
Tolerance to ABO A-Antigen Following Treatment of Infant Mice with A-Expressing MHC-Identical Erythrocytes
B. Motyka¹, J. Fersovich¹, M. Sulzer¹, I. Adam¹, J. Pearcey¹, K. Tao¹, C. W. Cairo², P. J. Cowan³, L. J. West¹
¹Dept Pediatrics, Alberta Transplant Institute, Canadian Donation and Transplant Research Program, University of Alberta, Edmonton, AB, Canada, ²Department of Chemistry, University of Alberta, Edmonton, AB, Canada, ³Immunology Research Centre, St Vincent's Hospital, Melbourne, Australia
*Purpose: ABO-incompatible heart transplantation (ABOi HTx) is safe in young children and increases donor access. Post-ABOi HTx, B cell tolerance develops to donor ABO blood…
2019 American Transplant Congress
Decay Accelerating Factor (DAF) Regulates Germinal Center B-cell and Alloantibody Formation
A. Cumpelik¹, G. Varano², D. Heja¹, D. Homann³, S. Lira⁴, D. Dominguez-Sola², P. S. Heeger¹
¹Nephrology, Mount Sinai School of Medicine, New York, NY, ²Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, ³Medicine, Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, NY, ⁴Clinical Immunology, Mount Sinai School of Medicine, New York, NY
*Purpose: High affinity IgG antibodies including alloantibodies result from germinal center (GC) reactions in which somatic hypermutation and positive selection cause affinity maturation. When we…