2019 American Transplant Congress
Anti CD45RB Antibody Therapy Attenuates Renal Ischemia Reperfusion Injury by Inducing Regulatory B Cells
*Purpose: Regulatory B cells (Bregs) are a new B cell subset that suppresses immune responses. Recently, both anti-CD45RB and anti-Tim-1 treatments have been found to…2019 American Transplant Congress
TACI Polymorphisms Associated with Increased Alloimmunity and Allograft Rejection
*Purpose: Transmembrane activator and CAML interactor (TACI) controls B cell differentiation. The TACI gene is highly polymorphic (>95% of all genes) and frequently variants exhibit…2019 American Transplant Congress
Epstein Barr Virus DNA Integration in B Cell Lymphomas of Post-Transplant Lymphoproliferative Disorder
Surgery, Division of Abdominal Transplant, Stanford University School of Medicine, Stanford, CA
*Purpose: Epstein Barr virus-positive (EBV+) B cell lymphomas can arise in immunosuppressed individuals, such as organ transplant recipients in the context of post-transplant lymphoproliferative disorder…2019 American Transplant Congress
Role of MHC Class II in B Cell and Regulatory T Cell Development
Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Therapies involving CD4 regulatory T cells (Tregs) are promising approaches to mitigate graft rejection and autoimmunity. Understanding of the activation mechanisms that initiate Treg…2019 American Transplant Congress
BCMA Expression by Alloreactive B Cells Increases during De Novo Alloantibody Responses
Comprehensive Transplant Center, Cedars-Sinai Med Ctr, Los Angeles, CA
*Purpose: BCMA(TNFRSF17) belongs to tumor necrosis factor receptor superfamily. It is selectively expressed during B/plasma cell differentiation while being nearly absent on naive and memory…2019 American Transplant Congress
A Step-Wise Desensitization Using Rituximab&Bortezomib Combined with Antithymocyte Globulin for Highly Sensitized Kidney Transplant Candidates
Hiroshima University, Hiroshima, Japan
*Purpose: In highly HLA sensitized patients, both memory B and T cells responding to donor-specific HLA in addition to plasma cells secreting anti-HLA Abs are…2019 American Transplant Congress
Iguratimod Inhibits the Donor Specific Antibodies Production and Attenuates the Antibody Mediated Rejection in Rat Kidney Transplantation
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: Our study was designed to investigate the efficacy and related mechanisms of Iguratimod (T-614) in the inhibition of DSAs following kidney transplantation.*Methods: A rat…2019 American Transplant Congress
Treg-Lymphatic Crosstalk: Lymphotoxin Signals as Modulators of Immunity and Suppression
*Purpose: Little is known about the molecular cues that regulate the entry of leukocytes across lymphatic vessels. Regulatory T cells (Treg) express high amounts of…2019 American Transplant Congress
Tolerance to ABO A-Antigen Following Treatment of Infant Mice with A-Expressing MHC-Identical Erythrocytes
*Purpose: ABO-incompatible heart transplantation (ABOi HTx) is safe in young children and increases donor access. Post-ABOi HTx, B cell tolerance develops to donor ABO blood…2019 American Transplant Congress
Decay Accelerating Factor (DAF) Regulates Germinal Center B-cell and Alloantibody Formation
*Purpose: High affinity IgG antibodies including alloantibodies result from germinal center (GC) reactions in which somatic hypermutation and positive selection cause affinity maturation. When we…
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