ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "B cells"

  • 2022 American Transplant Congress

    Perturbing Proteostasis to Deplete Plasma Cells

    A. Rossi1, A. Burg1, K. Roskin1, A. Shields2, R. Alloway2, E. Woodle2, D. Hildeman1

    1Cincinnati Children's Hospital, Cincinnati, OH, 2University of Cincinnati College of Medicine, Cincinnati, OH

    *Purpose: Alloantibodies play critical roles in rejection and often prevent sensitized patients from receiving life-sustaining transplants. One approach for enhancing transplantation rates and survival for…
  • 2022 American Transplant Congress

    Alloprimed Antibody-Suppressor CD8+ T Cells Preferentially Kill Alloprimed Germinal Center B Cells

    J. Zimmerer, S. Chaudhari, G. Bumgardner

    OSUWMC, Columbus, OH

    *Purpose: Antibody-mediated rejection (AMR) is a significant contributor to transplant rejection. Our prior work identified a novel subset of CXCR5+CD8+ T cells (CD8+ TAb-supp cells)…
  • 2022 American Transplant Congress

    B and Plasma Cell Populations Drive Chronic Rejection After Lung Transplantation

    M. Bueno1, N. F. Smirnova2, K. Riemondy3, P. Suresh1, M. Brown1, X. Wang1, S. Collins4, J. Sembrat1, M. Koenigshoff1, M. Snyder1, J. McDyer1, O. Eickelberg1

    1Pulmonary and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, 2I2MC, INSERM UMR1297, Toulouse, France, 3Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, 4Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO

    *Purpose: Chronic lung allograft dysfunction (CLAD) remains the major determinant of morbidity and mortality post-lung transplantation (LTx). Bronchiolitis obliterans syndrome (BOS) is the most prevalent…
  • 2022 American Transplant Congress

    B Cells Fit for Germinal Center Activity Predict Response to a Third Dose of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients

    E. A. Thompson1, A. H. Karaba1, K. Cascino1, K. Roznik1, T. Chiang1, L. Biavatti1, A. T. Abedon1, J. L. Alejo1, S. L. Klein1, J. N. Blankson1, D. S. Warren1, C. X. Qin1, J. Mitchell1, J. M. Garonzik-Wang2, B. J. Boyarsky1, D. L. Segev1, A. A. Tobian1, W. A. Werbel1, A. L. Cox1, J. R. Bailey1

    1Johns Hopkins University, Baltimore, MD, 2University of Wisconsin School of Medicine and Health, Madison, WI

    *Purpose: While SARS-CoV-2 vaccination has dramatically reduced COVID-19 severity in the general population, fully vaccinated solid organ transplant recipients (SOTRs) demonstrate reduced seroconversion and increased…
  • 2022 American Transplant Congress

    Characterization Of Local Antibody Responses In Human Cardiac Allograft Vasculopathy

    S. B. See1, L. J. Stanton1, P. Roy1, S. Mashiko1, E. R. Vasilescu2, C. C. Marboe2, M. Szabolcs2, M. V. Habal3, M. Farr3, S. Restaino3, Y. Naka4, D. M. Mancini5, J. C. Madsen6, R. G. King7, E. P. Kransdorf8, E. Zorn1

    1CCTI, Columbia University Irving Medical Center, New York, NY, 2Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 3Medicine, Columbia University Irving Medical Center, New York, NY, 4Surgery, Columbia University Irving Medical Center, New York, NY, 5Cardiology, Icahn School of Medicine, New York, NY, 6CTS, Massachusetts General Hospital, Boston, MA, 7Microbiology, University of Alabama, Birmingham, AL, 8Cedars-Sinai Heart Institute, Los Angeles, CA

    *Purpose: Cardiac allograft vasculopathy (CAV) is the leading cause of heart graft recipient mortality after five years post-transplant. A major hurdle to improving outcomes is…
  • 2022 American Transplant Congress

    Synergistic Effect of CXCR5+CD8+ TAb-supp Cell Adoptive Cell Therapy and mTOR Inhibition (but Not Calcineurin Inhibition) in Suppressing Alloantibody Following Kidney Transplant in Mice

    J. L. Han1, J. M. Zimmerer1, Q. Zeng2, S. Chaudhari1, C. K. Breuer2, G. L. Bumgardner1

    1Dept. of Surgery, The Ohio State University, Columbus, OH, 2Center for Regen. Med., The Research Institute at Nationwide Children's Hospital, Columbus, OH

    *Purpose: We have reported that CXCR5+CD8+TAb-supp cells mediate suppression of alloantibody (alloAb) production and prolong graft survival in both hepatocellular and kidney transplant (KTx) mouse…
  • 2022 American Transplant Congress

    The Roles of Intrarenal B Cells in Regulating Antibody Mediated Rejection After Kidney Transplantation

    H. Zhang1, C. Cavazzoni1, E. Bechu1, B. Hanson1, M. A. Podestà1, D. Kreisel2, A. Alessandrini3, P. Sage1

    1Transplantation Research Center, Renal Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 2Department of Surgery, Washington University in St Louis, St. Louis, MO, 3Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard, Boston, MA

    *Purpose: Alloimmune rejection after kidney transplantation is associated with substantial infiltration of immune cells such as T and B cells in transplanted grafts. However, the…
  • 2022 American Transplant Congress

    High Dimensional Analysis of IL-10-Producing Human B Cells and Their Characterization in Operationally Tolerant Transplant Recipients

    M. C. Glass, D. Glass, J. Oliveria, B. Mbiribindi, C. Esquivel, S. M. Krams, S. C. Bendall, O. M. Martinez

    Stanford University Sch of Med, Stanford, CA

    *Purpose: Regulatory B cells (Breg) participate in control of alloimmune responses in murine models of graft tolerance and are associated with improved outcomes in clinical…
  • 2022 American Transplant Congress

    Faster B Cell Rebound is Observed Following Xenotransplantation Compared to Allotransplantation in a Highly Sensitized Nonhuman Primate Kidney Transplantation Model

    I. DeLaura, M. Manook, D. Olaso, J. Yoon, R. Baldi, S. Knechtle, J. Kwun

    Surgery, Duke Transplant Center, Durham, NC

    *Purpose: Xenotransplantation outcomes have been greatly improved due to the advent of genetically engineered pigs and agents targeting the CD40-CD40L signaling pathway. However, studies have…
  • 2022 American Transplant Congress

    Marginal Zone B Cells Support T Cell Reconstitution Following ATG Lymphoablation in Heart Allograft Recipients.

    Y. Yamamoto, R. Fan, M. Nicosia, V. Gorbacheva, R. Fairchild, A. Valujskikh

    Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH

    *Purpose: Lymphoablation with anti-thymocyte globulin (ATG) is a common therapy in solid organ transplantation. However homeostatic proliferation of pre-existing memory T cells undermines the graft-prolonging…
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