ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "B cells"

  • 2019 American Transplant Congress

    Iguratimod Inhibits the Donor Specific Antibodies Production and Attenuates the Antibody Mediated Rejection in Rat Kidney Transplantation

    Z. Wang, M. Zheng, H. Chen, S. Li, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu

    No.300 Guangzhou Road of Nanjing, Nanjing, China

    *Purpose: Our study was designed to investigate the efficacy and related mechanisms of Iguratimod (T-614) in the inhibition of DSAs following kidney transplantation.*Methods: A rat…
  • 2019 American Transplant Congress

    Treg-Lymphatic Crosstalk: Lymphotoxin Signals as Modulators of Immunity and Suppression

    W. Piao1, L. Li2, V. Saxena2, Y. Xiong2, C. Paluskievicz2, J. Bromberg3

    1Microbiology and Immunology, U. Maryland, Baltimore, baltimore, MD, 2Surgery, U. Maryland, Baltimore, Baltimore, MD, 3Surgery and Microbiology and Immunology, U. Maryland, Baltimore, Baltimore, MD

    *Purpose: Little is known about the molecular cues that regulate the entry of leukocytes across lymphatic vessels. Regulatory T cells (Treg) express high amounts of…
  • 2019 American Transplant Congress

    Tolerance to ABO A-Antigen Following Treatment of Infant Mice with A-Expressing MHC-Identical Erythrocytes

    B. Motyka1, J. Fersovich1, M. Sulzer1, I. Adam1, J. Pearcey1, K. Tao1, C. W. Cairo2, P. J. Cowan3, L. J. West1

    1Dept Pediatrics, Alberta Transplant Institute, Canadian Donation and Transplant Research Program, University of Alberta, Edmonton, AB, Canada, 2Department of Chemistry, University of Alberta, Edmonton, AB, Canada, 3Immunology Research Centre, St Vincent's Hospital, Melbourne, Australia

    *Purpose: ABO-incompatible heart transplantation (ABOi HTx) is safe in young children and increases donor access. Post-ABOi HTx, B cell tolerance develops to donor ABO blood…
  • 2019 American Transplant Congress

    Decay Accelerating Factor (DAF) Regulates Germinal Center B-cell and Alloantibody Formation

    A. Cumpelik1, G. Varano2, D. Heja1, D. Homann3, S. Lira4, D. Dominguez-Sola2, P. S. Heeger1

    1Nephrology, Mount Sinai School of Medicine, New York, NY, 2Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, 3Medicine, Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, NY, 4Clinical Immunology, Mount Sinai School of Medicine, New York, NY

    *Purpose: High affinity IgG antibodies including alloantibodies result from germinal center (GC) reactions in which somatic hypermutation and positive selection cause affinity maturation. When we…
  • 2019 American Transplant Congress

    B Cell Derived Exosomes Are Associated with Antibody Mediated Rejection in Kidney Transplant Recipients Desensitized for a Positive Cross-Match

    D. Cucchiari1, V. Tubita2, M. J. Ramirez-Bajo2, J. Rovira2, F. E. Borràs3, L. Carreras-Planella3, A. Hertig4, F. Oppenheimer1, F. Diekmann1, I. Revuelta1

    1Renal Transplant Unit, Hospital Clínic, Barcelona, Spain, 2Laboratori Experimental de Nefrologia i Trasplantament, IDIBAPS, Barcelona, Spain, 3REMAR-IVECAT group, IGTP, Badalona, Spain, 4Department of Nephrology and Kidney Transplantation, Hôpital Tenon, Paris, France

    *Purpose: Kidney transplant recipients undergoing desensitization for a positive cross-match are at very high risk of developing Antibody-Mediated Rejection (AMR). Because of desensitization, peripheral circulating…
  • 2019 American Transplant Congress

    Acquired Resistance to Transplantation Tolerance as a Result of Prior Pregnancy Requires B Cells

    D. V. Tran, A. N. Suah, S. Khiew, J. S. Young, Q. Wang, D. Yin, M. Alegre, A. S. Chong

    Departments of Surgery and Medicine, University of Chicago, Chicago, IL

    *Purpose: Clinical data suggest allogeneic pregnancy is a sensitizing event; however, data from mouse models suggests it induces fetal-specific regulatory T cell (Treg) expansion and…
  • 2019 American Transplant Congress

    Tertiary Lymphoid Organs in Renal Chronic Allograft Rejection

    K. Abou-Daya, D. Zhao, A. Williams, M. Oberbarnscheidt

    Starzl Transplantation Institute, Pittsburgh, PA

    *Purpose: Chronic allograft rejection remains a major obstacle to long-term allograft survival. Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues…
  • 2019 American Transplant Congress

    Effect of Everolimus on IgM and IgG Memory B Cell Growth and Survival In Vitro and Applications for Effective Administration in Clinical Practice

    Y. Matsuda

    Osaka University Graduate School of Medicine, Osaka, Japan

    *Purpose: Everolimus (EVR), which is converted from CNI, is reported to improve renal function and reduce renal toxicity, DSA production, and rejection development. However, there…
  • 2019 American Transplant Congress

    CyTOF and RNAseq Analyses Unravel Early Phenotypic and Transcriptional Changes in Antibody-Secreting and Memory B Cells >1 Year Prior to Antibody-Mediated Rejection

    C. Fischman1, M. Fribourg1, J. Ansari2, L. Gallon2, F. Ginevri3, P. Comoli4, M. Cioni3, A. Nocera3, M. Bruschi3, C. Cantarelli1, L. Perin5, P. Cravedi1

    1Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 2Department of Medicine, Northwestern University, Chicago, IL, 3Department of Medicine, IRCCS Istituto G. Gaslini, Genoa, Italy, 4Department of Medicine, IRCCS San Matteo Hospital, Pavia, Italy, 5Department of Urology, Children's Hospital Los Angeles, Los Angeles, CA

    *Purpose: While the negative impact of anti-HLA donor specific antibodies (DSA) on graft outcomes has been extensively investigated, little is known about early changes in…
  • 2019 American Transplant Congress

    ICOS+PD-1+ Circulating T Follicular Helper Cells Are a Biomarker of Humoral Alloreactivity and Predict Donor-Specific Antibody Generation Following Transplantation

    G. M. La Muraglia II, M. E. Wagener, M. L. Ford, I. R. Badell

    Emory Transplant Center, Atlanta, GA

    *Purpose: Mounting evidence in kidney transplantation suggests that donor-specific antibodies (DSA) significantly contribute to renal allograft loss. However, biomarkers to guide clinical management of DSA…
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