2019 American Transplant Congress
Cyclo (his-pro) Protects Against Gentamicin Induced Cell Apoptosis And Cisplatin Induced Acute Kidney Injury Through Inhibiting P53 Mediated Apoptotic Pathway.
*Purpose: Cyclo(His-Pro) (CHP) is an endogenous cyclic dipeptide that exerts cellular protective effects against anti-oxdative damages. However, the role and mechanisms for CHP in preventing…2019 American Transplant Congress
FcγRIIB is a Novel CD8+ Effector T Cell Intrinsic Regulatory Pathway That Correlates with Freedom from Rejection in Renal Transplant Patients
*Purpose: To understand the functional role and clinical relevance of FcγRIIB on CD8+ T cells in transplantation.*Methods: See results*Results: FcγRIIB is the sole inhibitory Fcγ…2019 American Transplant Congress
Bcl-2/Bcl-xL Inhibition by Navitoclax vs. Bcl-2 Alone Inhibition by Venetoclax for Induction of Mixed Chimerism in Non-Human Primates
*Purpose: We recently demonstrated that a specific Bcl-2 inhibitor, Venetoclax, can promote mixed chimerism and renal allograft tolerance in non-human primates (NHPs) with reduced myelosuppressive…2019 American Transplant Congress
NQO-1 Attenuates Renal Ischemia-Reperfusion Injury in Mice
*Purpose: Ischemia-reperfusion (I-R)-induced reactive oxygen species (ROS) are thought to be a major factor in the development of acute renal injury by promoting the initial…2019 American Transplant Congress
Sigma-1 Receptor Agonists Are Renoprotective in a Rat Model of Kidney Transplantation
*Purpose: Kidney transplantation is associated with better quality of life and reduced costs compared to dialysis, but the shortage in donor organs is a limiting…2019 American Transplant Congress
Predominant Role of Microvascular over Tubular Injury as Driver of Progressive Renal Damage and Fibrosis Post Ischemia Reperfusion Injury
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for allograft dysfunction and chronic renal failure. Although tubular epithelial cells (TEC) are considered the main…2019 American Transplant Congress
Hypothermic Protection Attenuates Kidney Injury in Renal Ischemia-Reperfusion Injury via Phosphorylation of ERK
*Purpose: Hypothermia attenuates the renal injury induced by ischemia-reperfusion. However, the detailed molecular pathway remains unknown. ERK and HIF1 are known to protect against ischemia-reperfusion…2019 American Transplant Congress
CD38 Inhibition: A Novel Target for Hepatic Ischemia Reperfusion Injury
*Purpose: Ischemia/reperfusion injury (IRI) is a major source of injury during many surgical procedures on the liver, and severe IRI can lead to post-hepatectomy liver…2019 American Transplant Congress
Normothermic Ex Situ Liver Perfusion with Different Clinical Perfusates and Their Effect on Pig Liver Transplant Outcomes in a Donation after Circulatory Death Model
Toronto General Hospital, Toronto, ON, Canada
*Purpose: Human-albumin/Dextran (HA-D), Bovine-gelatin (BG) and packed red blood cells plus plasma have been used in European and North-American clinical trials of normothermic ex-situ liver…2019 American Transplant Congress
Human Mesenchymal Stem Cells Inhibits Hypoxia-Induced Islets Apoptosis via Regulation of Autophagy
The Third Xiang Ya Hospital,Central South University, ChangSha, China
*Purpose: Xenotransplantation of porcine islets has been an emerging and effective option for clinicians to treat type 1 diabetes recently. Comparing with other damage, hypoxic…
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