ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Apoptosis"

  • 2019 American Transplant Congress

    Erk-elk1-mir-711 Signalling In Cardiac Ischemia Reperfusion Injury In Heart Transplantation

    H. Zheng, Y. Su, C. Zhu, V. Veramkovich, X. Zheng

    Pathology, University of Western Ontario, London, ON, Canada

    *Purpose: This study aims to discover new molecular mechanisms involved in and to develop new treatment for preventing ischemia reperfusion injury in heart transplantation.*Methods: The…
  • 2019 American Transplant Congress

    Phenotype and Course of Renal Tubular Cell Death during Cold Ischemia versus Cold Ischemia Followed by Transplant

    S. Jain1, R. Plenter2, T. Nydam2, A. Jani1

    1Renal Division, University of Colorado, Aurora, CO, 2Transplant Microsurgery Program, University of Colorado, Aurora, CO

    *Purpose: Treatments of Delayed graft function (DGF) are lacking. Prolonged cold ischemia (CI) is a risk factor for DGF but the pathways by which CI…
  • 2019 American Transplant Congress

    Ceria-Zirconia Nanoparticles as an Enhanced Antioxidant Attenuates Apoptosis of Human Kidney Proximal Tubular Epithelial Cells in Hypoxia

    S. Yoon1, K. Yoon2, S. Hong3, S. Yun1, W. Hwang1, J. Moon4, J. Lee1, H. Jeon1

    1Nephrology, Konyang University Hospital, Daejeon, Korea, Republic of, 2Hannam University, Daejeon, Korea, Republic of, 3Chemistry, Hannam University, Daejeon, Korea, Republic of, 4General Surgery, Konyang University Hospital, Daejeon, Korea, Republic of

    *Purpose: Ischemia/reperfusion injury, resulting from hypoxic damage within a graft, is the leading cause of delayed graft function and graft rejection. Various mechanisms have been…
  • 2019 American Transplant Congress

    Bcl-2 Inhibition with Venetoclax Promotes Induction of Mixed Chimerism and Renal Allograft Tolerance without Severe Myelosuppression in Non-Human Primate

    H. Sasaki1, D. Ma1, T. Oura1, A. Dehnadi1, I. Rosales2, B. Cosimi1, P. Cippa3, T. Fehr3, T. Kawai1

    1Surgery, Massachusetts General Hospital, Boston, MA, 2Pathology, Massachusetts General Hospital, Boston, MA, 3Medicine, University of Zurich, Zurich, Switzerland

    *Purpose: Specific Bcl-2 inhibition has been shown to promote mixed chimerism and skin allograft tolerance without myelosuppressive conditioning in murine models. To extend this approach…
  • 2019 American Transplant Congress

    The Impact of Thrombin / Protease-Activated Receptor-1 Pathway in Hepatic Ischemia-Reperfusion Injury in Mice

    D. Noguchi, N. Kuriyama, T. Fujii, H. Kato, M. Kishiwada, S. Mizuno, M. Usui, H. Sakurai, S. Isaji

    Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu City, Mie, Japan

    *Purpose: Coagulation cascade is an important pathway in the pathophysiology of hepatic ischemia-reperfusion injury(IRI). Generation of thrombin is a critical factor of coagulation induced by…
  • 2019 American Transplant Congress

    Apoptotic Exosome-Like Vesicles Induce Endothelial Cell Plasticity and Accelerate Allograft Vascular Remodeling

    F. Migneault1, M. Dieudé1, J. Turgeon1, A. Karakeussian Rimbaud1, D. Beillevaire1, M. Hardy2, A. Brodeur1, N. Thibodeau1, C. Perreault2, M. Hébert1

    1CRCHUM, Montreal, QC, Canada, 2IRIC, Montreal, QC, Canada

    *Purpose: Acute vascular rejection of allografts is associated with endothelial apoptosis which in turn contributes to the development of transplant vasculopathy. We previously showed that…
  • 2019 American Transplant Congress

    Nephrotoxicity Caused by Calcineurin Inhibitors is Meditated by BAX, NOL3 and XIAP Apoptotic Genes Dysregulation

    G. Queipo1, M. Fonsecha-Sanchez1, J. Sanchez1, L. Garcia1, M. Carmona2, E. Villanueva1, G. Melendez1, L. Morales-Buenrostro3, M. Alamilla1

    1Hospital General de Mexico-Eduardo Liceaga Facultad de Medicina UNAM, Mexico City, Mexico, 2Facultad de Medicina UNAM, Mexico City, Mexico, 3Instituto Nacional de Ciencias Médicas Salvador Zubirán, Mexico City, Mexico

    *Purpose: Calcineurin inhibitors (CNI) remain the most effective and widely used immunosuppressive agents in kidney transplantation. Nephrotoxicity is a major secondary effect, and renal biopsy…
  • 2019 American Transplant Congress

    Glycogen Synthase Kinase 3alpha Serine 21 Phosphorylation Inhibits Hepatocyte Autophagy to Facilitate Liver Ischemia Reperfusion Injury

    M. Ni1, H. Zhou2, R. Busuttil1, J. Kupiec-Weglinski1, X. Wang2, Y. Zhai1

    1Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA, 2Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: Glycogen synthase kinase 3 (Gsk3) has α and β isoforms. They are constitutively active in cells and inhibited upon stimulations by N-terminal serine phosphorylation.…
  • 2019 American Transplant Congress

    Bespoke Immunosuppression: Prolonging Transplant Survival through Enhanced T-cell Activation Induced Cell Death

    R. Costello1, R. J. Ingram1, D. Longley2, J. McDaid3

    1WWIEM, QUB, Belfast, United Kingdom, 2CCRCB, QUB, Belfast, United Kingdom, 3Renal Transplantation, Belfast City Hospital, Belfast, United Kingdom

    *Purpose: We aim to develop donor-specific immunosuppression by inhibiting T-cell cellular FLICE like inhibitory protein (c-FLIP). Our current work focuses on clinically relevant pharmacological inhibitors…
  • 2019 American Transplant Congress

    Apoptosis during Cold Ischemia and Rewarming Involves a Caspase Independent Pathway

    S. Jain1, R. Plenter2, T. Nydam2, A. Jani1

    1Renal Division, University of Colorado, Aurora, CO, 2Transplant Microsurgery Program, University of Colorado, Aurora, CO

    *Purpose: We have previously shown that hibernating ground squirrels (GS) tolerate core body temperatures of 4°C for several days with a heart rate that is…
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