Articles tagged "Apoptosis"

2019 American Transplant Congress
Sigma-1 Receptor Agonists Are Renoprotective in a Rat Model of Kidney Transplantation
A. Hosszu¹, Z. Antal², L. Illesy², L. Lenart¹, D. B. Balogh¹, L. Wagner³, A. Vannay⁴, A. J. Szabo², A. Fekete¹
¹"Lendulet" Diabetes Research Group, MTA-SE, Budapest, Hungary, ²1st Department of Pediatrics, Semmelweis University, Budapest, Hungary, ³Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary, ⁴Pediatrics and Nephrology Research Group, MTA-SE, Budapest, Hungary
*Purpose: Kidney transplantation is associated with better quality of life and reduced costs compared to dialysis, but the shortage in donor organs is a limiting…
2019 American Transplant Congress
Predominant Role of Microvascular over Tubular Injury as Driver of Progressive Renal Damage and Fibrosis Post Ischemia Reperfusion Injury
S. Lan¹, B. Yang¹, M. Dieudé¹, J. Sabo-Vatasescu², A. Karakeussian-Rimbaud², J. Turgeon², S. Qi³, N. Patey⁴, M. Hébert¹
¹Medicine Faculty, CRCHUM, University of Montreal, Montreal, QC, Canada, ²CRCHUM, Montreal, QC, Canada, ³Department of Surgery, CRCHUM, University of Montreal, Montreal, QC, Canada, ⁴Department of Pathology and Cell Biology, CHU Saint-Justine, University of Montreal, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for allograft dysfunction and chronic renal failure. Although tubular epithelial cells (TEC) are considered the main…
2019 American Transplant Congress
Hypothermic Protection Attenuates Kidney Injury in Renal Ischemia-Reperfusion Injury via Phosphorylation of ERK
D. Choi¹, J. Jeong², K. Lee¹, K. Na¹, Y. Chang³, Y. Ham¹, J. Jeon¹, H. Kim¹
¹Nephrology, Chungnam National University, Daejeon, Korea, Republic of, ²Medical Science, Chungnam National University, Daejeon, Korea, Republic of, ³Nephrology, Catholic University of Korea, Daejeon, Korea, Republic of
*Purpose: Hypothermia attenuates the renal injury induced by ischemia-reperfusion. However, the detailed molecular pathway remains unknown. ERK and HIF1 are known to protect against ischemia-reperfusion…
2019 American Transplant Congress
CD38 Inhibition: A Novel Target for Hepatic Ischemia Reperfusion Injury
C. Akateh¹, B. F. Reader¹, Y. Lee¹, J. Kim¹, K. Maynard¹, K. W. Washburn¹, J. L. Zweier², B. A. Whitson¹, S. M. Black¹
¹Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, ²The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: Ischemia/reperfusion injury (IRI) is a major source of injury during many surgical procedures on the liver, and severe IRI can lead to post-hepatectomy liver…
2019 American Transplant Congress
Normothermic Ex Situ Liver Perfusion with Different Clinical Perfusates and Their Effect on Pig Liver Transplant Outcomes in a Donation after Circulatory Death Model
I. Linares-Cervantes, D. Kollmann, T. Goto, J. Echeverri, M. Kaths, M. Hamar, P. Urbanellis, L. Mazilescu, R. Rosales, C. Bruguera, F. Oquendo, S. Ganesh, O. Adeyi, P. Yip, N. Selzner, M. Selzner
Toronto General Hospital, Toronto, ON, Canada
*Purpose: Human-albumin/Dextran (HA-D), Bovine-gelatin (BG) and packed red blood cells plus plasma have been used in European and North-American clinical trials of normothermic ex-situ liver…
2019 American Transplant Congress
Human Mesenchymal Stem Cells Inhibits Hypoxia-Induced Islets Apoptosis via Regulation of Autophagy
R. Pengfei, X. Yuzhi
The Third Xiang Ya Hospital,Central South University, ChangSha, China
*Purpose: Xenotransplantation of porcine islets has been an emerging and effective option for clinicians to treat type 1 diabetes recently. Comparing with other damage, hypoxic…
2019 American Transplant Congress
Erk-elk1-mir-711 Signalling In Cardiac Ischemia Reperfusion Injury In Heart Transplantation
H. Zheng, Y. Su, C. Zhu, V. Veramkovich, X. Zheng
Pathology, University of Western Ontario, London, ON, Canada
*Purpose: This study aims to discover new molecular mechanisms involved in and to develop new treatment for preventing ischemia reperfusion injury in heart transplantation.*Methods: The…
2019 American Transplant Congress
Phenotype and Course of Renal Tubular Cell Death during Cold Ischemia versus Cold Ischemia Followed by Transplant
S. Jain¹, R. Plenter², T. Nydam², A. Jani¹
¹Renal Division, University of Colorado, Aurora, CO, ²Transplant Microsurgery Program, University of Colorado, Aurora, CO
*Purpose: Treatments of Delayed graft function (DGF) are lacking. Prolonged cold ischemia (CI) is a risk factor for DGF but the pathways by which CI…
2019 American Transplant Congress
Ceria-Zirconia Nanoparticles as an Enhanced Antioxidant Attenuates Apoptosis of Human Kidney Proximal Tubular Epithelial Cells in Hypoxia
S. Yoon¹, K. Yoon², S. Hong³, S. Yun¹, W. Hwang¹, J. Moon⁴, J. Lee¹, H. Jeon¹
¹Nephrology, Konyang University Hospital, Daejeon, Korea, Republic of, ²Hannam University, Daejeon, Korea, Republic of, ³Chemistry, Hannam University, Daejeon, Korea, Republic of, ⁴General Surgery, Konyang University Hospital, Daejeon, Korea, Republic of
*Purpose: Ischemia/reperfusion injury, resulting from hypoxic damage within a graft, is the leading cause of delayed graft function and graft rejection. Various mechanisms have been…
2019 American Transplant Congress
Bcl-2 Inhibition with Venetoclax Promotes Induction of Mixed Chimerism and Renal Allograft Tolerance without Severe Myelosuppression in Non-Human Primate
H. Sasaki¹, D. Ma¹, T. Oura¹, A. Dehnadi¹, I. Rosales², B. Cosimi¹, P. Cippa³, T. Fehr³, T. Kawai¹
¹Surgery, Massachusetts General Hospital, Boston, MA, ²Pathology, Massachusetts General Hospital, Boston, MA, ³Medicine, University of Zurich, Zurich, Switzerland
*Purpose: Specific Bcl-2 inhibition has been shown to promote mixed chimerism and skin allograft tolerance without myelosuppressive conditioning in murine models. To extend this approach…

« Previous Page
1
…
3
4
5
6
7
…
13
Next Page »