Articles tagged "Apoptosis"

2019 American Transplant Congress
Bespoke Immunosuppression: Prolonging Transplant Survival through Enhanced T-cell Activation Induced Cell Death
R. Costello¹, R. J. Ingram¹, D. Longley², J. McDaid³
¹WWIEM, QUB, Belfast, United Kingdom, ²CCRCB, QUB, Belfast, United Kingdom, ³Renal Transplantation, Belfast City Hospital, Belfast, United Kingdom
*Purpose: We aim to develop donor-specific immunosuppression by inhibiting T-cell cellular FLICE like inhibitory protein (c-FLIP). Our current work focuses on clinically relevant pharmacological inhibitors…
2019 American Transplant Congress
Apoptosis during Cold Ischemia and Rewarming Involves a Caspase Independent Pathway
S. Jain¹, R. Plenter², T. Nydam², A. Jani¹
¹Renal Division, University of Colorado, Aurora, CO, ²Transplant Microsurgery Program, University of Colorado, Aurora, CO
*Purpose: We have previously shown that hibernating ground squirrels (GS) tolerate core body temperatures of 4°C for several days with a heart rate that is…
2019 American Transplant Congress
Eupatilin Ameliorates Tacrolimus Induced Nephrotoxicity via Inhibiting Apoptosis
H. J. Jang, C. S. Park, M. Y. Oh
Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Korea, Republic of
*Purpose: Tacrolimus (FK506) is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and…
2019 American Transplant Congress
Role of NF-kB in Release of Isletokines via Exosomes in Response to Islet Stress
P. Saravanan¹, M. Kanak¹, J. Kalivarathan¹, M. Lawrence², M. Levy¹, B. Naziruddin³
¹Department of Surgery, Virginia Commonwealth University, VCU Health, Richmond, VA, ²Islet Cell Lab, Baylor Scott and White Research Institute, Dallas, TX, ³Simmons Transplant Institute, Baylor Scott and White Medical Center, Dallas, TX
*Purpose: Human islets are exposed to a range of inflammatory stimuli upon transplantation that leads to poor graft survival. Identifying the various signaling events may…
2019 American Transplant Congress
Cyclo (his-pro) Protects Against Gentamicin Induced Cell Apoptosis And Cisplatin Induced Acute Kidney Injury Through Inhibiting P53 Mediated Apoptotic Pathway.
Y. Kim¹, J. Moon¹, J. Jeong¹, J. Kim¹, S. Lee¹, M. Yu², C. Lee³, Y. Kim¹, S. Yang⁴
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Internal Medicine, Hanyang University Medical Center, Seoul, Korea, Republic of, ³Internal Medicine, Cheju Halla General Hospital, Cheju, Korea, Republic of, ⁴Kidney Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Cyclo(His-Pro) (CHP) is an endogenous cyclic dipeptide that exerts cellular protective effects against anti-oxdative damages. However, the role and mechanisms for CHP in preventing…
2019 American Transplant Congress
FcγRIIB is a Novel CD8⁺Effector T Cell Intrinsic Regulatory Pathway That Correlates with Freedom from Rejection in Renal Transplant Patients
A. B. Morris¹, D. F. Pinelli¹, D. Liu¹, J. M. Boss², C. D. Scharer², M. Fribourg³, P. Cravedi³, P. S. Heeger³, M. L. Ford¹
¹Surgery, Emory University, Atlanta, GA, ²Micro & Immuno, Emory University, Atlanta, GA, ³Center for Translational Transplant Research, Icahn SOM at Mount Sinai, New York, NY
*Purpose: To understand the functional role and clinical relevance of FcγRIIB on CD8+ T cells in transplantation.*Methods: See results*Results: FcγRIIB is the sole inhibitory Fcγ…
2019 American Transplant Congress
Bcl-2/Bcl-xL Inhibition by Navitoclax vs. Bcl-2 Alone Inhibition by Venetoclax for Induction of Mixed Chimerism in Non-Human Primates
H. Sasaki¹, D. Ma¹, T. Oura¹, A. Dehnadi¹, I. Rosales², B. Cosimi¹, P. Cippa³, T. Fehr³, T. Kawai¹
¹Surgery, Massachusetts General Hospital, Boston, MA, ²Pathology, Massachusetts General Hospital, Boston, MA, ³Medicine, University of Zurich, Zurich, Switzerland
*Purpose: We recently demonstrated that a specific Bcl-2 inhibitor, Venetoclax, can promote mixed chimerism and renal allograft tolerance in non-human primates (NHPs) with reduced myelosuppressive…
2019 American Transplant Congress
NQO-1 Attenuates Renal Ischemia-Reperfusion Injury in Mice
D. Choi¹, J. Hwang², J. Jeong³, K. Lee¹, K. Na¹, Y. Ham¹, J. Jeon¹, H. Kim¹, Y. Chang¹
¹Nephrology, Chungnam National University, Daejeon, Korea, Republic of, ²Laboratory Animal Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, Republic of, ³Medical Science, Chungnam National University, Daejeon, Korea, Republic of
*Purpose: Ischemia-reperfusion (I-R)-induced reactive oxygen species (ROS) are thought to be a major factor in the development of acute renal injury by promoting the initial…
2019 American Transplant Congress
Sigma-1 Receptor Agonists Are Renoprotective in a Rat Model of Kidney Transplantation
A. Hosszu¹, Z. Antal², L. Illesy², L. Lenart¹, D. B. Balogh¹, L. Wagner³, A. Vannay⁴, A. J. Szabo², A. Fekete¹
¹"Lendulet" Diabetes Research Group, MTA-SE, Budapest, Hungary, ²1st Department of Pediatrics, Semmelweis University, Budapest, Hungary, ³Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary, ⁴Pediatrics and Nephrology Research Group, MTA-SE, Budapest, Hungary
*Purpose: Kidney transplantation is associated with better quality of life and reduced costs compared to dialysis, but the shortage in donor organs is a limiting…
2019 American Transplant Congress
Predominant Role of Microvascular over Tubular Injury as Driver of Progressive Renal Damage and Fibrosis Post Ischemia Reperfusion Injury
S. Lan¹, B. Yang¹, M. Dieudé¹, J. Sabo-Vatasescu², A. Karakeussian-Rimbaud², J. Turgeon², S. Qi³, N. Patey⁴, M. Hébert¹
¹Medicine Faculty, CRCHUM, University of Montreal, Montreal, QC, Canada, ²CRCHUM, Montreal, QC, Canada, ³Department of Surgery, CRCHUM, University of Montreal, Montreal, QC, Canada, ⁴Department of Pathology and Cell Biology, CHU Saint-Justine, University of Montreal, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for allograft dysfunction and chronic renal failure. Although tubular epithelial cells (TEC) are considered the main…

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