2015 American Transplant Congress » Poster Session D: Innate Immunity in Transplantation

Date: Tuesday, May 5, 2015

Time: 5:30pm-6:30pm

Location: Exhibit Hall E

Session Type: Poster Session

Meeting: 2015 American Transplant Congress

5:30pm-6:30pm: A Mouse Model of Pneumonitis Induced by Candida Albicans Infection After Allogeneic Skin Transplantation

A. Yang, Z. Guo, W. Ju, Y. Ma, A. Hu, Y. Chen, M. Chen, C. Wu, X. He.

5:30pm-6:30pm: A Novel Signaling Approach for the Prevention of Ischemia/Reperfusion Injury (IRI)

S. Khalid,¹ M. Haller,¹ K. Koziel,¹ M. Enthammer,¹ M. Hermann,² M. Thurner,¹ L. Kremser,³ H. Lindner,³ J. Troppmair.¹

5:30pm-6:30pm: A Specific Inhibitor of C1s, TNT003, Prevents Complement-Mediated Enhancement of Monocyte Adhesion to Endothelium in Response to HLA Antibodies

N. Valenzuela,¹ K. Thomas,¹ A. Mulder,² G. Parry,³ S. Parker,³ E. Reed.¹

5:30pm-6:30pm: Activated Protein C Treatment Protects Steatotic and Non-Steatotic Livers Under Ischemia–Reperfusion Injury in Different Manner

A. Matsuda, N. Kuriyama, H. Kato, Y. Azumi, M. Kishiwada, S. Mizuno, M. Usui, S. Isaji.

5:30pm-6:30pm: Activation of FXR Protects Against Liver Ischemia and Reperfusion Injury (IRI) in Mice Via the PI 3-Kinase/Akt (PI3K/Akt) Pathway

J. Zhang,¹ X. Liu,² D. Li,¹ H. Dai,¹ J. Zhang,¹ T. Lu,¹ Q. Xia.¹

5:30pm-6:30pm: An Orchestrated Sequence of Innate and Adaptive Immune Responses Is Associated With Rejection After Pediatric Liver Transplantation

C. Falk,¹ I. Goldschmidt,² F. Mutschler,² C. Neudörfl,¹ J. Keil,¹ K. Daemen,¹ F. Lehner,³ R. Mikolajzcyk,⁴ A. Karch,⁴ U. Baumann.²

5:30pm-6:30pm: Antithymocyte Globulin-Induced Platelet Hypercoagulability Is a Consequence of Complement Activation and Microvesicle Release

D. Zecher,^1,4 A. Cumpelik,¹ D. Tsakiris,² M. Dickenmann,³ J. Schifferli.¹

5:30pm-6:30pm: CD52-Negative NK Cells Are Abundant in the Liver and Less Susceptible to Alemtuzumab Treatment

R. Hotta,¹ M. Ohira,² T. Matsuura,¹ I. Muraoka,¹ P. Tryphonopoulos,¹ J. Fan,¹ A. Tekin,¹ H. Ohdan,² A. Tzakis,³ R. Vianna,¹ S. Nishida.¹

5:30pm-6:30pm: CHBP in Preservation Solution and Autologous Blood Perfusate Ameliorates Ischemia Reperfusion Injury in Isolated Porcine Kidneys

C. Yang,¹ S. Hosgood,² H. Carly,² P. Meeta,² Y. Long,³ T. Zhu,¹ M. Nicholson,² B. Yang.²

5:30pm-6:30pm: Cellular Mechanism of Enhanced Alloimmunity by Ischemia Reperfusion Injury

Z. Solhjou, M. Uehara, S. Ohori, M. McGrath, J. Azzi, S. Tullius, R. Abdi.

5:30pm-6:30pm: Chemokine Receptor 5 Blockade Modulates Inflammation and Immunity in Renal Ischemic Reperfusion Injury

K. Yoo,¹ S. Han,¹ J. Park,¹ E. Bae,¹ J. Park,¹ J. An,¹ J. Lee,¹ D. Kim,¹ Y. Kim,^1,2 S. Yang.²

5:30pm-6:30pm: Clusterin-Regulated Transcriptome in the Kidney During Ischemia-Reperfusion

G. Dairi, Q. Guan, A. Haegert, C. Collins, M. Gleave, C. Nguan, C. Du.

5:30pm-6:30pm: Damage Associated Molecular Patterns (DAMPs)-Activated Neutrophil Extracellular Trap Formation Exacerbates Liver Ischemia/Reperfusion Injury

H. Huang, S. Tohme, A. Al-Khafaji, A. Tsung.

5:30pm-6:30pm: Diabetes Exacerbates Liver Ischemia and Reperfusion Injury By Activating the AGE-RAGE Pathway in Kupffer Cells

S. Yue, J. Zhu, J. Rao, J. Kupiec-Weglinski, R. Busuttil, Y. Zhai.

5:30pm-6:30pm: Distinct Roles of CD137 and CD137L Bi-Directional Signaling in Candida albicans Infection

H. Cho,^1,2 J. Lee,^2,3 V. Tran,⁴ B. Kwon.^2,4

5:30pm-6:30pm: Hepatic Stellate Cells Inhibit T Cells Through Active TGFβ1 from a Cell-Surface-Bound Latent TGFβ1/GARP Complex

Y. Li, B.-G. Kim, S. Qian, J. Letterio, J. Fung, L. Lu, F. Lin.

5:30pm-6:30pm: Human Bone Marrow Mesenchymal Stem Cell-Derived Hepatocytes Express TIMP-4 and Follistatin

J. Li,¹ J. Xin,¹ W. Ding,² S. Hao,¹ L. Jiang,¹ Q. Zhou,¹ T. Wu,¹ D. Shi,¹ L. Li.¹

5:30pm-6:30pm: Inflammasome Activation in Hepatocytes and Kupffer Cells Orchestrates the Hepatotoxic Effect of Bile Acids and Can Be Potential Target in the Management of Cholestatic Liver Injury

X. Liu,¹ T. Ma,¹ T. Billiar,² R. Tao.¹

5:30pm-6:30pm: Interleukin-17 Deficiency Attenuates Renal Allograft Injury and Prolongs Survival in a Murine Transplantation Model

T. Kwan,^1,2 S. Chadban,^1,2 J. Ma,^1,2 S. Bao,^2,3 S. Alexander,^2,4 H. Wu.^1,2

5:30pm-6:30pm: Low Molecular Weight Hyaluronan Increases MIG and MCP-1 Production in Cardiac Allografts

S. Goparaju,¹ A. Kaul,¹ N. Dvorina,¹ S. Iida,¹ K. Keslar,¹ R. Fan,¹ C. de la Motte,² A. Valujskikh,¹ R. Fairchild,¹ W. Baldwin III.¹

5:30pm-6:30pm: Macrophage Specific β-Catenin Controls ROCK/PTEN Function and Regulates Innate Immunity in Liver Inflammation

S. Yue,¹ X. Zhou,² M. Zhou,¹ Y. Zhai,¹ R. Busuttil,¹ Q. Ying,² J. Kupiec-Weglinski,¹ B. Ke.¹

5:30pm-6:30pm: Macrophage-Specific SIRT1 Regulates HO-1 Mediated Anti-Inflammatory and Cytoprotective Pathways

K. Nakamura,¹ M. Zhang,² B. Ke,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹

5:30pm-6:30pm: Mitochondrial Hydrogen Sulphide Donor Molecules Are More Effective Against Hypoxic Injury in Renal Tubular Epithelial Cells

G. Aboalsamh,^1,5 M. Saha,² I. Lobb,² J. Grewal,² P. Luke,^1,2,3 M. Wood,⁴ M. Whiteman,⁴ A. Sener.^1,2,3

5:30pm-6:30pm: NK Cells of Kidney Transplant Recipients Show a Reduced Capacity to Produce Cytokines But Retain Their Cytotoxic Capacity

U. Hoffmann,¹ C. Neudoerfl,¹ K. Daemen,¹ J. Keil,¹ C. Blume,^2,3 F. Lehner,⁴ H. Haller,² C. Falk.^1,5

5:30pm-6:30pm: Neogenin Functions as a Chemokinetic Receptor on Activated CD4+ T Lymphocytes

L. Boneschansker,¹ H. Nakayama,¹ M. Eisenga,¹ M. Klagsbrun,¹ D. Irimia,² D. Briscoe.¹

5:30pm-6:30pm: Non-Invasive Immune Monitoring Assay in Transplant Recipients

M. Gasser,¹ I. Tsaur,² K. Lopau,¹ C. Germer,¹ A. Chandraker,³ A. Waaga-Gasser.¹

5:30pm-6:30pm: Oxidative Stress During Organ Recovery Influences Transplant Vasculopathy Development

M. Maglione,¹ G. Riede,¹ B. Cardini,¹ D. Bernhard,² B. Messner,² K. Watschinger,³ C. Steger,⁴ G. Brandacher,⁵ J. Pratschke,¹ E. Werner,³ R. Oberhuber.¹

5:30pm-6:30pm: Perfusion Disturbances and Local Infarctions After Experimental Kidney Transplantation Corralte With the Duration of Cold Ischemia Time

S. Rong,¹ R. Chen,¹ M. Meier,⁴ B. Hensen,² H. Haller,¹ K. Hueper,² F. Gueler.¹

5:30pm-6:30pm: Phenotype of Renal Tubular Cell Death During Delayed Graft Function

S. Jain,¹ R. Plenter,¹ T. Nydam,¹ C. Ruller,¹ C. Edelstein,^1,2 A. Jani.^1,2

5:30pm-6:30pm: Profound Effect of HDAC2 Deletion on Renal Ischemia-Reperfusion Injury Is Intrinsic to the Kidney and Includes Protection Against Cold Ischemia

D. Aufhauser, Jr.,¹ Z. Wang,¹ S. Cheraghlou,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.^1,4

5:30pm-6:30pm: Recipient Myelomonocytic Cells With Activated Hypoxia-Inducible Factor Alleviate Ischemia-Reperfusion Injury in Mouse Heart Allografts

A. Raissadati, M. Keränen, E. Rouvinen, R. Krebs, K. Lemström.

5:30pm-6:30pm: Role of Complement in Mediating Pericyte Trans-Differentiation in Resident Myofibroblasts: A New Hypothesis On Vascular Rarefaction in Renal Ischemia/Reperfusion (I/R) Injury

G. Castellano,¹ R. Franzin,¹ C. Divella,¹ A. Stasi,¹ A. Intini,¹ M. Gigante,¹ G. Lucarelli,¹ P. Ditonno,¹ M. Battaglia,¹ A. Crovace,¹ F. Staffieri,¹ G. Pertosa,¹ B. Oortwijn,² E. Amersfoort,² G. Grandaliano,³ L. Gesualdo.¹

5:30pm-6:30pm: Significant Reduction in TRAIL-Expressing NK Cells in Remnant Liver After Partial Hepatectomy Is Strongly Associated With the Impaired Intrahepatic CXCL9–CXCR3 Pathway

T. Yano, M. Ohira, H. Ohdan.

5:30pm-6:30pm: TGR5 Regulates Innate Immune Responses in Mouse Liver Ischemia-Reperfusion Injury Through NRF2/HO-1 Signaling Pathway

J. Rao, B. Hao, X. Wang, F. Zhang, L. Lu.

5:30pm-6:30pm: The Effects of Periostin on Renal Fibrosis After Ischemia-Reperfusion Injury Via p38 MAPK Pathway

J. An,^1,2 S. Yang,³ J. Hwang,⁴ J. Kim,¹ S. Kim,^2,5 C. Lim,^1,2 Y. Oh,^1,2 Y. Kim,² J. Lee.^1,2

5:30pm-6:30pm: The Impact of Cytokine Release Caused By Induction Immunosupression On Nitric Oxide in Renal transplantation

R. Johns,^1,2 M. Laftsidis,² E. Burrows,² F. Edwards,² E. Ablorsu,² P. James,¹ A. Phillips,^1,2 A. Asderakis.²

5:30pm-6:30pm: The Impact of FcγRIIA, FcγRIIIA and C1QA Genes Polymorphism On Infectious Complications Following Renal Transplantation

L. Das, Y. Tanaka, S. Verma, S. Shimizu, K. Ide, H. Ohdan.

5:30pm-6:30pm: The Influence of Immunosuppressive Drugs On the Epithelial Microenvironment in Solid Organ Transplantation – Identification of Biomarker Candidates for Rejection Vs. Tolerance

A. Akhdar,¹ B. Mueller,² C. Neudoerfl,¹ F. Lehner,³ M. Stevanovic-Meyer,¹ K. Daemen,¹ J. Keil,¹ H. Haller,⁴ C. Blume,^4,5 C. Falk.^1,6

5:30pm-6:30pm: The Liver X Receptor Alpha (LXRα) Knockout Protect Liver Against Ischemia-Reperfusin Injury in Mice

T. Lu,¹ D. Li,¹ J. Zhang,¹ M. Zhang,¹ X. Cui,¹ H. Dai,¹ X. Liu,² Q. Xia.¹

5:30pm-6:30pm: The Role of Inflammasome Components in Renal Tubular Epithelial Cell Injury

S. Kasimsetty, A. Shigeoka, D. McKay.

5:30pm-6:30pm: Type III Phosphodiesterase (PDE3) Inhibitor Improves Survival Rate After Ischemia Reperfusion Injury of the Liver in Rats

T. Fujii,¹ H. Obara,² N. Fujimura,² K. Matsubara,² Y. Kitagawa.²

5:30pm-6:30pm: miR-155 Different Roles in UCB iTreg and nTreg

Y. Lu, L. Lu.

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