2019 American Transplant Congress » Poster Session A: Ischemia Reperfusion & Organ Rehabilition

5:30pm-7:30pm

Alpha-1 Antitrypsin Reduces Liver Ischemia Reperfusion Injury during Ex-Vivo Normothermic Machine Perfusion

D. Detelich¹, R. de Vries¹, C. Carroll¹, M. Stein², K. Uygun¹, H. Yeh¹, J. Markmann¹

5:30pm-7:30pm

Aquaporins May Be Involved in Renal Ischemia-Reperfusion Injury by Affecting the Pyroptosis of Renal Tubular Epithelial Cells

T. Lin, Y. Fan, Y. Jiang, J. Liu, Z. Wang, L. Li, T. Song, Z. Huang, X. Wang

5:30pm-7:30pm

CD38 Inhibition: A Novel Target for Hepatic Ischemia Reperfusion Injury

C. Akateh¹, B. F. Reader¹, Y. Lee¹, J. Kim¹, K. Maynard¹, K. W. Washburn¹, J. L. Zweier², B. A. Whitson¹, S. M. Black¹

5:30pm-7:30pm

Determining the Molecular Nature and Role of Cytoglobin in Chronic Allograft Nephropathy

D. Patel¹, T. Divanyan¹, E. Acosta¹, K. Carnes², D. Howard³, F. Jourd’heuil³, D. Jourd’heuil³, R. Lopez-Soler⁴

5:30pm-7:30pm

Distinct Delayed Classical Complement Pathway Activation Highlights Transition of Ischemic Acute Kidney Injury to Chronic Kidney Disease with Interstitial Fibrosis/Tubular Atrophy

S. Kumar, S. Jordan

5:30pm-7:30pm

Donor Renal Macrophages in Post-Transplant Ischemia/Reperfusion Injury (IRI): Role of IL-1R8 in Modulating Fate, Phenotype and Function

S. Aiello, P. Rodriguez, N. Azzollini, F. Casiraghi, M. Noris, G. Remuzzi, A. Benigni

5:30pm-7:30pm

Evaluation of New Baskent University Preservation Solution for Liver, Kidney and Intestine Graft during Cold Ischemia: Preliminary Experimental Animal Study

M. Haberal¹, M. Kirnap¹, R. Erdem², H. Ozdemir³, M. Lux², D. Bacanli⁴

5:30pm-7:30pm

Flow Cytometric Analysis of Leukocyte Migration during Ex Vivo Lung Perfusion with CXCR4 Inhibition

J. Yerxa¹, Q. Gao¹, R. P. Davis², M. Zhang¹, U. Scheuermann¹, W. Parker¹, M. G. Hartwig², A. Barbas¹

5:30pm-7:30pm

Graft TIM4 Deficiency Protects Liver from Ischemia Reperfusion Injury: From Mouse to Human

S. Kageyama¹, K. Kadono¹, H. Hirao¹, K. Nakamura¹, T. Ito², K. J. Dery¹, D. Oncel¹, B. Ke¹, F. M. Kaldas², R. W. Busuttil², J. W. Kupiec-Weglinski¹

5:30pm-7:30pm

Heart-Associated Cytokine and Endothelial Patterns Dominate the Ischemia/Reperfusion Response in Recipients of Combined Heart/Lung Transplantation in Comparison to Lung Transplantation

F. Wandrer¹, B. Wiegmann², N. Ledwoch¹, R. Bellmas Sanz¹, F. Ius², W. Sommer², S. Rojas², C. Kühn², I. Tudorache², M. Avsar², A. Haverich², G. Warnecke², C. S. Falk¹

5:30pm-7:30pm

Hypothermic Protection Attenuates Kidney Injury in Renal Ischemia-Reperfusion Injury via Phosphorylation of ERK

D. Choi¹, J. Jeong², K. Lee¹, K. Na¹, Y. Chang³, Y. Ham¹, J. Jeon¹, H. Kim¹

5:30pm-7:30pm

Impact of Time-of-Day of Declamping on Kidney Transplant Outcome

D. Montaigne¹, N. Al Hawajri², M. Jacquelinet¹, A. Coppin¹, M. Frimat³, S. Bouyé³, G. Lebuffe³, F. Bayer², M. Lassalle², B. Staels¹, M. Hazzan³, C. Jacquelinet⁴

5:30pm-7:30pm

Indocyanine Green Fluorescence Imaging during Normothermic Ex Vivo Liver Perfusion for the Assessment of Hepatocyte, Biliary, and Vascular Function

T. Goto, I. Linares, S. Ganesh, L. Mazilescu, P. Urbanellis, N. Selzner, M. Selzner

5:30pm-7:30pm

Inhibition of Cyclin-Dependent Kinase 2 Signaling Prevents Liver Ischemia and Reperfusion Injury

Z. Xue, J. Xu, C. Zhang, Y. Liu, R. Busuttil, J. Kupiec-Weglinski, H. Ji

5:30pm-7:30pm

Ischemic Preconditioning Attenuates Renal Ischemia-Reperfusion Injury through Activating the Nrf2/HO-1 Pathway Enhanced Autophagy

H. Choi¹, Y. Kim², M. Kim², K. Jun², S. Kim², S. Park³, J. Kim⁴, I. Moon⁵, J. Hwang⁶

5:30pm-7:30pm

Kidney-Intrinsic Innate Immunity and Endoplasmic Reticulum Stress Pathways are Key Determinants of Severity of Ischemia-Reperfusion Injury Following Transplantation

L. Qiu¹, J. Wang¹, X. Yeap¹, C. Lin¹, Y. S. Kanwar², D. Fang², M. M. Abecassis¹, Z. J. Zhang¹

5:30pm-7:30pm

Kupffer Cells Are Critical for Inflammation Resolution in Liver Ischemia Reperfusion Injury via TIM-4 Mediated Efferocytosis

M. Ni¹, H. Wang¹, D. Jin¹, J. Zhang¹, R. Busuttil¹, J. Kupiec-Weglinski¹, X. Wang², Y. Zhai¹

5:30pm-7:30pm

Loss of FXR Exacerbates Liver Damage by Activating NLRP3 Inflammasome Induced Pyroptosis in Liver Ischemia Reperfusion Injury

Z. Zhu, Y. Zhang, Y. Tang, S. Huang, Q. Zhao, W. Ju, Z. Guo, X. He

5:30pm-7:30pm

Multi-omic Analysis Of Hepatic Ischemia/reperfusion Injury Identifies Novel Targets To Mitigate Hepatocellular Damage

S. Duarte¹, V. Boominathan², Z. Huo³, A. Kobayashi², U. Kim², Y. Lai², A. Coito¹, A. Zarrinpar²

5:30pm-7:30pm

NQO-1 Attenuates Renal Ischemia-Reperfusion Injury in Mice

D. Choi¹, J. Hwang², J. Jeong³, K. Lee¹, K. Na¹, Y. Ham¹, J. Jeon¹, H. Kim¹, Y. Chang¹

5:30pm-7:30pm

Normothermic Ex Situ Liver Perfusion with Different Clinical Perfusates and Their Effect on Pig Liver Transplant Outcomes in a Donation after Circulatory Death Model

I. Linares-Cervantes, D. Kollmann, T. Goto, J. Echeverri, M. Kaths, M. Hamar, P. Urbanellis, L. Mazilescu, R. Rosales, C. Bruguera, F. Oquendo, S. Ganesh, O. Adeyi, P. Yip, N. Selzner, M. Selzner

5:30pm-7:30pm

Novel Molecular Mechanisms Associated with Normothermic Ex-Vivo Kidney Perfusion

C. McEvoy¹, T. Tokar², S. Reid³, P. Urbanellis³, M. Hamar¹, M. Kaths¹, I. Jurisica², L. Robinson⁴, M. Selzner¹, A. Konvalinka¹

5:30pm-7:30pm

Optimizing a Protocol for Extended Ex-Vivo Extremity Perfusion

C. J. Stewart¹, M. T. Buchko², X. Wang¹, G. Brandacher³, A. Ladak⁴, D. H. Freed², J. Nagendran²

5:30pm-7:30pm

Perfluorocarbon (PFC) Solutions for Organ Preservation

N. Battula, T. Parsons, J. Zhu, C. Giordano, A. Esnakula, B. Spiess, M. Johnson, A. Zarrinpar, K. Andreoni

5:30pm-7:30pm

Pharmacological Mobilization of Host Stem Cells Prevents Delayed Graft Function Following Kidney Transplantation in Rats

W. Wang, L. Qi, J. Huang, A. Ahmadi, A. Krishnan, R. Wesson, A. Cameron, Z. Sun

5:30pm-7:30pm

Predominant Role of Microvascular over Tubular Injury as Driver of Progressive Renal Damage and Fibrosis Post Ischemia Reperfusion Injury

S. Lan¹, B. Yang¹, M. Dieudé¹, J. Sabo-Vatasescu², A. Karakeussian-Rimbaud², J. Turgeon², S. Qi³, N. Patey⁴, M. Hébert¹

5:30pm-7:30pm

Randomized Controlled Trial Of Spironolactone Effect In Kidney Transplant Recipients Of Living Donors

N. A. Bobadilla¹, L. E. Morales-Buenrostro¹, J. A. Ortega-Trejo¹, R. Perez-Villalva¹, L. Marino¹, Y. González-Bobadilla¹, H. Juarez¹, F. Zamora-Mejía¹, N. Gonzalez¹, R. Espinoza², J. Barrera-Chimal³

5:30pm-7:30pm

Recombinant Apoptosis Inhibitor of Macrophage Protein Ameliorates Transplant Ischemia-Reperfusion Injury

J. Y. Lee¹, X. Zhang², D. Lian³, A. R. Haig⁴, T. Miyazaki⁵, L. Gunaratnam⁶

5:30pm-7:30pm

Reverse Signaling through CD137 Ligand Promotes Tissue Repair after Ischemia-Reperfusion Kidney Injury

H. R. Cho¹, S. Lee², J. S. Lee³, S. J. Park¹, B. Kwon²

5:30pm-7:30pm

Sigma-1 Receptor Agonists Are Renoprotective in a Rat Model of Kidney Transplantation

A. Hosszu¹, Z. Antal², L. Illesy², L. Lenart¹, D. B. Balogh¹, L. Wagner³, A. Vannay⁴, A. J. Szabo², A. Fekete¹

5:30pm-7:30pm

Soluble C Type Lectin Receptor Protein Inhibition of Natural Killer Cell Mediated Tubular Epithelial Cell Death

S. Balaji¹, B. Fuhrmann², D. Lian³, H. Diao³, S. Ma³, Z. Zhang³, A. M. Jevnikar³

5:30pm-7:30pm

Tubastatin-A, an HDAC6 Inhibitor, is Protective in Liver Ischemia Reperfusion Injury and Acetaminophen-Mediated Liver Injury

S. Concors¹, D. Murken¹, P. Hernandez¹, D. Aufhauser¹, Z. Wang¹, G. Ge¹, L. Krumeich¹, T. Bhatti², A. Kozikowski³, W. Hancock², M. H. Levine¹

5:30pm-7:30pm

Withaferin A as a Possible Therapy for Chronic Allograft Nephropathy

T. Divanyan¹, D. Patel¹, E. Acosta¹, D. Howard², F. Jourd'heuil², D. Jourd'heuil², R. Lopez-Soler³