2018 American Transplant Congress » Poster Session A: Biomarkers, Immune Monitoring and Outcomes

Date: Saturday, June 2, 2018

Time: 5:30pm-7:30pm

Location: Hall 4EF

Session Type: Poster Session

Meeting: 2018 American Transplant Congress

5:30pm-7:30pm: A Novel Preservation Solution for Lung That Improves Cell Viability and Tissue Architecture

J. Friedman,¹ M. Samamrco,¹ L. Marrero,¹ B. Bunnell,¹ D. Spyropoulos.²

5:30pm-7:30pm: AT1R Antibody Analysis: High Proportion of Non-Specific Reactivity?

A. Halpin,^1,3,4,5 S. Abou-Zeki,³ I. Larsen,^1,4 P. Campbell,^2,3,4,5 S. Urschel,^1,4,5 L. West.^1,3,4,5

5:30pm-7:30pm: Absolute Quantification of Plasma Graft-Derived Cell-Free DNA for Diagnosis of Kidney Transplant Rejection

J. Whitlam,¹ L. Ling,² F. Ierino,³ D. Bruno,² H. Slater,² D. Power.¹

5:30pm-7:30pm: Acute Tubular and Glomerular Kidney Injury Markers Reflect Ischemia-Reperfusion and Rejection

Y. Shim, R. Fan, N. Dvorina, W. Baldwin.

5:30pm-7:30pm: Assessment of Hepatic Ischemia-Reperfusion Injuries by NRF2-Dependent Transcriptional Activities of Bile Transporters in Rats

J. Kim,¹ A. Martin,¹ J. Yee,¹ L. Fojut,¹ A. Geurts,² K. Oshima,³ M. Zimmerman,¹ J. Hong.¹

5:30pm-7:30pm: Assessment of Immune Cell Profiles in HLA-Sensitized (HS) & Non-HS Patients (Pts) with End Stage Renal Disease (ESRD)

S. Ge,¹ M. Chu,¹ E. Ortiz,¹ A. Vo,² D. Lovato,¹ S. Jordan,² M. Toyoda.¹

5:30pm-7:30pm: Association of Leptin with Cystatin C in Kidney Allograft Dysfunction

A. Bera,¹ M. Watson,² N. Gana,¹ J. Karaian,¹ S. Radhakrishnan,¹ M. Subramanian,¹ D. Little,² R. Nee,² A. Chatterjee,¹ S. Rothwell,¹ H. Pollard,¹ R. Jindal,³ M. Srivastava.¹

5:30pm-7:30pm: Association of CYP3A5*3*6*7 Metabolic Composites to Tacrolimus Pharmacokinetics in African American and Caucasian Renal Transplant Recipients

K. Tornatore,^1,5 D. Brazeau,² C. Meaney,¹ K. Attwood,^3,4 G. Wilding,⁴ S. Chang,⁵ R. Venuto.⁵

5:30pm-7:30pm: Bioinformatics Approach to the Development of a Novel Molecular Biomarker for Sub-Clinical Acute Rejection (subAR) in the Peripheral Blood Following Kidney Transplant (KT)

T. Whisenant,¹ S. Kurian,¹ M. Kandpal,² L. Zhao,² D. Ikle,³ B. Armstrong,³ J. Friedewald,² R. Heilman,⁴ E. Poggio,⁵ C. Marsh,¹ P. Baliga,⁶ N. Bridges,⁷ J. Odim,⁷ M. Brown,⁷ J. Charette,² S. Brietigam,² N. Sustento-Reodica,² D. Salomon,¹ M. Abecassis.²

5:30pm-7:30pm: Brain Death Conditions Intensify Inflammation and Impair Metabolic Gene Expression

L. Zitur, P. Chlebeck, S. Odorico, T. Zens, J. Danobeitia, M. Eerhart, J. Reyes, A. D'Alessandro, K. Brunner, S. Capuano, L. Fernandez.

5:30pm-7:30pm: Changes in Phenotype, Immune Suppressive, Function, and Gene Expression of Myeloid Derived Suppressor Cells in Patients Given Combined Kidney and Hematopoietic Cell Transplants in a Tolerance Protocol

K. Jensen,¹ P. Zheng,² J. Xuhuai,² A. Saraswathula,¹ J. Scandling,³ S. Busque,⁴ J. Shizuru,⁵ R. Lowsky,⁵ A. Shori,⁴ H. Maecker,² E. Engleman,¹ E. Meyer,⁵ S. Strober.¹

5:30pm-7:30pm: Characterization of Exosomal DNA from Human Lung Transplant Recipients

S. Bansal, M. Sharma, R. Walia, R. Bremner, M. Smith, T. Mohanakumar.

5:30pm-7:30pm: Circulating Follicular Helper T Cells (cTfh) in Renal Transplantation: Utility as Rejection Biomarker

R. Laguna-Goya,¹ A. Utrero-Rico,¹ F. Cano-Romero,¹ E. Gómez-Massa,² D. Arroyo,¹ P. Auñon-Rubio,³ A. Sevillano-Prieto,³ M. Castro-Panete,² A. Andrés,³ E. Paz-Artal.^1,2

5:30pm-7:30pm: Circulating Wnt Pathway Factors Are Non-Invasive Biomarkers of Transplant Vascular Injury

M. Seifert,¹ A. Malone,² L. Boohaker,¹ J. Gaut,² S. Jain,² D. Brennan,^2,3 R. Mannon.¹

5:30pm-7:30pm: Clinical Significance and Therapeutic Potential of Orosomucoid 1 for Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients

H. Higuchi,^1,2 K. Hotta,¹ D. Iwami,¹ J-.J. Jiang,² D. Kamimura,² Y. Arima,² T. Atsumi,² Y. Takada,^1,2 H. Harada,³ M. Murakami,² N. Shinohara.¹

5:30pm-7:30pm: DNA Methylation Age and Differential Patterns of DNA Methylation in Older Compared with Younger Kidney Transplant Recipients

J. Schaenman, X. Zhou, R. Guo, M. Rossetti, E. Liang, B. Abdalla, E. Lum, S. Bunnapradist, G. Danovitch, E. Reed, D. Elashoff.

5:30pm-7:30pm: Different Expression Patterns of Exosomal miRNAs under Cyclosporin A and Rapamycin Treatment in Distinct Aggressiveness Colorectal Carcinomas

V. Tubita,¹ M. Ramírez-Bajo,¹ J. Lozano,² D. Moya-Rull,¹ J. Rovira,³ J. Campistol,^4,5,6 F. Diekmann,^1,4,5,6 I. Revuelta.^1,4,5,6

5:30pm-7:30pm: Dynamics of CD25-Positive Myeloid Suppressor Cells in Solid Organ Transplanted Patients and Relationship with Rejection

A. Utrero-Rico,¹ R. Laguna-Goya,¹ F. Cano-Romero,¹ E. Gómez-Massa,² M. Fernandez-Ruiz,³ J. Aguado,³ E. Mancebo-Sierra,² M. Castro-Panete,² E. Paz-Artal.^1,2

5:30pm-7:30pm: Elucidating Novel Signatures of Allograft Rejection through Cytometry by Time of Flight (CyTOF) in Kidney Transplant Recipients

S. Eskandari,¹ B. Al Dulaijan,¹ J. Assaker,¹ L. Riella,¹ A. Kurdi,² J. Azzi.¹

5:30pm-7:30pm: Evaluation of FlowDSA Crossmatch for Detection of Donor-Specific HLA Antibodies

J. Lee, J. Ryu, A. Choi, E-.J. Oh.

5:30pm-7:30pm: Extended Criteria Donors Have Higher Expression of Inflammatory Genes Than Standard Donors

M. Abbud-Filho,^1,2,3 M. Fernandes-Charpiot,^1,2 M. Baptista,^1,2 H. Caldas,^1,2 G. Florim.¹

5:30pm-7:30pm: False-Positive Flow-Cytometric T Cell Crossmatch Associated with Blood Type Antigen Expressed on Lymphocytes in ABO Incompatible Kidney Transplantation

D. Iwami,¹ M. Ito,² K. Hotta,¹ H. Higuchi,¹ N. Shinohara.¹

5:30pm-7:30pm: Global Expression Profiles of miRNA and Expression Patterns and Localization of the miR-21 in One-Hour Biopsy Specimens of Human Kidney Tansplantation from Donors after Cardiac Death

M. Kusaka,¹ N. Fukami,¹ H. Sasaki,¹ A. Kawai,¹ T. Kenmochi,² T. Ito,² R. Shiroki,¹ K. Hoshinaga.¹

5:30pm-7:30pm: Hyaluronic Acid as Early Biomarker of Graft Loss after Liver Transplantation: A Prospective Study

A. Rostved,¹ S. Ostrowski,² L. Peters,³ J. Lundgren,³ C. Sørensen,¹ H-.C. Pommergaard,¹ J. Hillingsø,¹ A. Rasmussen.¹

5:30pm-7:30pm: Identification of Exosomal Proteins from Human Lung Transplant Recipients

S. Bansal,¹ P. Pirrotte,² M. Saltzman,² K. Garcia,² M. Sharma,¹ M. Gunasekaran,¹ M. Smith,¹ R. Bremner,¹ T. Mohanakumar.¹

5:30pm-7:30pm: IgM HLA DSAs Do Not Alter the Outcomes of Renal Allograft Rejection

A. Gueret-Wardle,¹ P. Dodd,¹ G. Lucisano,¹ S. Hassan,¹ P. Brookes,² E. Santos-Nunez,² N. Firmin,² D. Goodall,¹ C. Roufosse,¹ M. Willicombe,¹ D. Taube.¹

5:30pm-7:30pm: Immune Phenotyping in a Pediatric Multicenter Transplant Study: Suitability of a Pre-Formulated Dry Antibody Panel System

S. Urschel,¹ L. Ionescu,¹ T. Blydt-Hansen,³ B. Foster,⁵ S. Mital,² U. Allan,² S. Iveson,³ L. Hamiwka,⁴ J. Yap,¹ V. Phan,⁵ P. Birk,⁶ L. West,¹ M. Levings.³

5:30pm-7:30pm: Impact of ELAD C3A Cell Conditioned Medium Enhanced Perfusate Fluid on Functional Recovery of Extended Criteria Donor Livers during Normothermic Machine Perfusion

S. Afford,² L. Wallace,² R. Laing,² Y. Botteon,² D. He,³ S. Soundararajan,⁴ D. Mirza,¹ R. Ashley,³ J. Brotherton,³ H. Mergental,¹ D. Reich.⁴

5:30pm-7:30pm: In-Situ Tissue-Based Gene Expression Profiling is a Reliable Method to Detect Gene Transcripts in Human Kidney Transplant Biopsies

D. Dobi,¹ J. Henrik,² T. Sigdel,² A. Chen,¹ Z. Laszik.¹

5:30pm-7:30pm: Intragraft MicroRNA Transcriptome of Acute Antibody Mediated Rejection of Human Kidney Allografts

H. Yang,¹ K. Akat,² C. Li,¹ C. Snopkowski,¹ Z. Khan,¹ D. Dadhania,¹ T. Tuschl,² M. Suthanthiran,¹ T. Muthukumar.¹

5:30pm-7:30pm: Intragraft MicroRNAs Foretell Fibrosis in Kidney Transplant Recipients

H. Yang,¹ L. Amrouche,² K. Akat,³ C. Li,¹ Z. Khan,¹ C. Tinel,² T. Tuschl,³ D. Anglicheau,² T. Muthukumar.¹

5:30pm-7:30pm: Involvement of Aldehyde Dehydrogenase 2 (ALDH2) in Fatty Liver Graft Protection Mechanisms against Cold Ischemic Injury

A. Panisello-Rosello,¹ A. Lopez,² C. Castro,² S. Bellogi,¹ E. Folch-Puy,¹ A. Rolo,³ C. Palmeira,³ R. Adam, J. Roselló-Catafau.

5:30pm-7:30pm: Ischemia Reperfusion Injury Significantly Differs between Lung vs. Heart Transplantation with Respect to Lead Cytokines and Correlation to Clinical Outcome

B. Wiegmann,¹ N. Ledwoch,² J. ISke,² C. Neudörfl,² I. Tudorache,¹ C. Kühn,¹ T. Kaufeld,¹ F. Ius,¹ S. Rojas,¹ M. Avsar,¹ A. Haverich,¹ G. Warnwcke,¹ C. Falk.¹

5:30pm-7:30pm: Isolation and Profiling of miRNAs from Formalin Fixed Paraffin Embedded Endomyocardial Tissues from Human Heart Transplant Recipients

R. Nog,^1,2 C. Gupta,^1,2 J. Fallon,^1,2 J. Panza,^1,2 N. Haque.²

5:30pm-7:30pm: Long-Term HIF-1α Stabilization is Associated with Fibrosis in Rat Lung Allografts

K. Freischlag,¹ B. Ezekian,¹ P. Schroder,¹ J. Everitt,¹ J. Yoon,¹ M. Swiderska-Syn,³ W. Parker,¹ A. Diehl,¹ J. Kwun,¹ S. Knechtle.¹

5:30pm-7:30pm: Longitudinal Molecular Assessment of Renal Allograft and Short-Term Outcome: Markers of Injury and Recovery

S. Bontha,¹ A. Fernandez,¹ E. Bardhi,¹ L. Gallon,² V. Mas,¹ D. Maluf.¹

5:30pm-7:30pm: Molecular Classifiers Can Outperform the Flawed Histologic “Gold Standard” on Which They Are Trained

J. Reeve, P. Halloran.

5:30pm-7:30pm: Multiple Factors Contribute to an Expanded Immune Risk Profile in Pre Renal Transplant Candidates

D. DeWolfe,¹ K. McGann,¹ J. Ghofrani,¹ E. Geiger,¹ C. Helzer,¹ S. Kleiboeker,² S. Jost,¹ C. Tan.¹

5:30pm-7:30pm: Non-Invasive Imaging Modalities for Immune Monitoring of Vascularized Composite Allografts Using a Translational Large Animal Model

J. Etra,¹ K. Cilwa,² G. Furtmueller,¹ A. Leto Barone,¹ K. Kolegraff,¹ E. Elster,¹ W. Lee,¹ G. Brandacher.¹

5:30pm-7:30pm: Non-Invasive Proteomics to Detect Biomarkers for Kidney Allograft Dysfunction

M. Watson,¹ M. Srivastava,³ D. Little,¹ O. Eidelman,³ R. Nee,¹ A. Bera,³ J. Karaian,³ D. Oliver,¹ H. Pollard,³ R. Jindal.²

5:30pm-7:30pm: Patients Converted to Belatacept Show Different Immunophenotyping Compared with De Novo Belatacept-Treated Patients

M. Rial,¹ F. Caro,² A. Nella,² D. Guerrieri,² L. León,¹ P. Uva,¹ E. Chuluyan,² D. Casadei.¹

5:30pm-7:30pm: Peripheral Blood Immune Response-Related Gene Analysis for Evaluating the Development of Subclinical Antibody-Mediated Rejection

T. Yamamoto,¹ K. Iwasaki,² K. Murotani,³ A. Takeda,⁴ M. Tsujita,⁴ T. Hiramitsu,⁴ N. Goto,⁴ S. Narumi,⁴ Y. Watarai,⁴ K. Uchida,² T. Kobayashi.⁵

5:30pm-7:30pm: Primary Cytomegalovirus Infection in Seronegative Kidney Transplant Patients is Associated with Prolonged Cold Ischemic Time of Seropositive Donor Organs

C. Falk,^1,7 F. Schlott,^2,7 K. Katsrintaki,^1,7 D. Steubl,³ W. Puppe,⁴ C. Blume,⁵ H. Haller,⁶ L. Renders,³ U. Heemann,³ D. Busch,² M. Neuenhahn.^2,7

5:30pm-7:30pm: Sensing T Cell Killing Activity with Granzyme B Activity Probes

Q. Mac,¹ D. Mathews,² J. Kahla,¹ C. Stoffers,¹ O. Delmas,¹ B. Holt,¹ A. Adams,² G. Kwong.¹

5:30pm-7:30pm: Serial Monitoring of Resolution of Sub-Clinical Acute Rejection (subAR) in Kidney Transplant Recipients (KTR) Using a Gene Expression Profile (GEP)

L. Zhao,¹ B. Armstrong,² J. Friedewald,¹ T. Whisenant,³ S. Kurian,³ R. Heilman,⁴ E. Poggio,⁵ C. Marsh,³ P. Baliga,⁶ N. Bridges,⁷ J. Odim,⁷ M. Brown,⁷ D. Ikle,² J. Charette,¹ S. Brietigam,¹ N. Sustento-Reodica,¹ M. Kandpal,¹ D. Salomon,³ M. Abecassis.¹

5:30pm-7:30pm: Stress-Related Exosomal MicroRNA Biomarkers Released by Human Islets during Transplantation

P. Saravanan,¹ P. Nguyen,¹ G. Yoshimatsu,¹ C. Chang,¹ C. Darden,¹ R. Bhattacharjee,¹ X. Wang,¹ J. Gu,¹ M. Lawrence,¹ B. Naziruddin.²

5:30pm-7:30pm: Tacrolimus Exposure in Human Proximal Tubule Cells Results in Differentially Increased CTGF Expression in Relation to Pharmacogenetic Variants of CYP3A5 and ABCB1

N. Knops,¹ Y. Ramazani,² B. Van den Heuvel,² R. Goldschmeding,³ T. Nguyen,³ E. Levtchenko,¹ D. Kuypers.⁴

5:30pm-7:30pm: Tax1bp3 is Upregulated in the Ischemia/Reperfusion Injury of Kidney

W. Qiu, J. Lin, Y. Tian.

5:30pm-7:30pm: The Impact of Childhood Solid Organ Transplantation on B-Cell Maturation

L. Ionescu,¹ T. Blydt-Hansen,² B. Foster,⁷ S. Mital,³ L. Hamiwka,⁵ U. Allan,³ V. Phan,⁴ P. Birk,⁶ C. Morgan,¹ S. Urschel.¹

5:30pm-7:30pm: The Inhibitory Effect of Plasma on Activation of Lymphocytes from Kidney Transplants is Significantly More Severe in Tacrolimus Based Regimen: What Implications for Plasma Exchange Role in Anti-Rejection Therapy?

A. Assounga,^1,2 S. Omarjee.¹

5:30pm-7:30pm: The Likelihood of Re-Transplantation in Patients Undergoing Allograft Nephrectomy

G. Lucisano,¹ P. Brookes,² E. Santos-Nunez,² N. Firmin,² N. Gunby,² S. Hassan,¹ A. Gueret-Wardle,¹ M. Willicombe,¹ D. Taube.¹

5:30pm-7:30pm: The Use of LiMAx for Evaluating Donor Livers on Normothermic Machine Perfusion

J. Schurink,¹ J. de Haan,² M. Verstegen,¹ H. Metselaar,³ J. Ijzermans,¹ J. de Jonge.¹

5:30pm-7:30pm: Time and Perfusate Dependent Molecular Response in Ex Vivo Lung Perfusion

P. Dromparis,¹ N. Aboelnazar,² S. Wagner,¹ S. Himmat,² C. White,² J. Luc,² D. Freed,² J. Nagendran,² M. Mengel,¹ B. Adam.¹

5:30pm-7:30pm: Urinary TIMP-2 Predicts the Presence and Duration of Delayed Graft Function in DCD Kidney Transplant Recipients

J. Bank,¹ R. Ruhaak,² D. Soonawala,¹ F. Romijn,² C. van Kooten,¹ C. Cobbaert,² H. de Fijter.¹

5:30pm-7:30pm: Urine AngiotensinII Signature Proteins as Biomarkers of Fibrosis in Kidney Transplant Recipients

Z. Mohammed-Ali,¹ S. Reid,^1,3 T. Tokar,¹ A. Tavares,² P. Yip,¹ H. Cardinal,² Y. Li,¹ S. Kim,^1,3 I. Jurisica,^1,3 R. John,¹ A. Konvalinka.^1,3

5:30pm-7:30pm: Validation Study of Operational Tolerance Signatures in Korean Kidney Transplantation Recipients

J. Seo,¹ Y. Lee,¹ Y. Kim,¹ J. Moon,¹ K-.H. Jeong,¹ C-.D. Kim,² J. Park,³ B. Jeong,⁴ S-.H. Lee.¹

5:30pm-7:30pm: What's Normal? An Evaluation of Pediatric T Cell Markers in Healthy Controls

M. Sosniuk,¹ A. Halpin,^1,2,5,6,7 J. Wizniak,⁷ A. Szkotak,^6,7 S. Urschel,^1,2,5 L. Ionescu,^1,2,5 L. West.^1,2,3,4,5,6

5:30pm-7:30pm: Whole-Transcriptome Sequencing to Identify Macaque Immune Gene Variants

A. Haj,¹ J. Karl,¹ R. Wiseman,¹ D. O'Connor.^1,2

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