Date: Saturday, June 2, 2018
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Hall 4EF
Introduction: Improved diagnosis and understanding the pathophysiology of early allograft dysfunction is essential to improve the short-term outcome after liver transplantation (LT). Hyaluronic acid (HA) is produced in connective tissue and is cleared from the blood by hepatic sinuisoidal endothelial cells with a low half-life. We investigated if HA measured after liver transplantation is associated with increased risk of graft loss.
Methods: Plasma sample were obtained on all consecutive adult DBD liver transplant recipients at a single centre. Samples were taken pretransplant and at day 1, 3, 7 and 14 days after LT. HA was measured by an enzyme-linked hyaluronic acid binding protein assay. Uni- and multivariate Cox regression assessed the association between HA and graft loss (all-cause mortality or retransplantation) up to 1 year with a minimum of 4 months.
Results: We included 106 patients of which 12 had graft loss. Hyaluronic acid was significantly higher for patients with graft loss at day 3, 7 and 14, but not pretransplant or at day 1. In the serial measurements day 3 HA was best at predicting graft loss (hazard ratio (HR) 1.15 per 50 [micro]g/l increase, 95% CI: 1.03 – 1.29, P = 0.01). The day 3 HA remained predictive of graft loss (HR 1.14 per 50 [micro]g/l increase, 95% CI: 1.01 – 1.29) when adjusted for eurotransplant donor risk index and renal replacement therapy at day 3. The optimal cut-off for HA to predict graft loss was 172 [micro]g/l, if below the graft survival was 96% (95% CI: 86 – 99%) if above 79% (95% CI: 62 – 89 %).
Conclusion: HA predicted short term graft loss and potentially a valuable biomarker of early allograft dysfunction. Elevated HA levels may reflect damage to hepatic sinusoidal endothelial cells and thus may reflect ischemic reperfusion injury.
CITATION INFORMATION: Rostved A., Ostrowski S., Peters L., Lundgren J., Sørensen C., Pommergaard H-.C., Hillingsø J., Rasmussen A. Hyaluronic Acid as Early Biomarker of Graft Loss after Liver Transplantation: A Prospective Study Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Rostved A, Ostrowski S, Peters L, Lundgren J, Sørensen C, Pommergaard H-C, Hillingsø J, Rasmussen A. Hyaluronic Acid as Early Biomarker of Graft Loss after Liver Transplantation: A Prospective Study [abstract]. https://atcmeetingabstracts.com/abstract/hyaluronic-acid-as-early-biomarker-of-graft-loss-after-liver-transplantation-a-prospective-study/. Accessed March 23, 2019.
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