ATC Abstracts

American Transplant Congress abstracts

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  • 2021 American Transplant Congress

    Natural Sensitization by Pregnancy, Testing Desensitization Strategies in Female NHPs Across Repeat Mismatches

    M. Manook, J. Yoon, Z. Fitch, R. Schmitz, A. M. Jackson, J. Kwun, S. Knechtle

    Duke Transplant Center, Duke University Medical Center, Durham, NC

    *Purpose: Women are disproportionately represented in the highly sensitized patient cohort, and HLA-incompatible transplantation is undertaken predominantly in females. However, nonhuman primate (NHP) models to…
  • 2021 American Transplant Congress

    Association of Donor Hepatitis C Virus Infection Status and Risk of Bk Polyomavirus Viremia After Kidney Transplantation

    V. S. Potluri1, D. E. Schaubel1, M. E. Sise2, B. P. Concepcion3, R. C. Forbes1, E. A. Blumberg1, D. Goldberg4, P. P. Reese1, R. Bloom1, D. Shaffer3, R. Chung2, D. Sawinski1, I. Strohben2, N. Elias2, A. Azhar5, M. Shah1, J. Eason5, L. A. Binari3, M. Talwar5, V. Balaraman5, A. Bhalla5, B. Besharatian1, M. Z. Molnar5

    1University of Pennsylvania, Philadelphia, PA, 2Massachusetts General Hospital, Boston, MA, 3Vanderbilt University Medical Center, Nashville, TN, 4University of Miami Miller School of Medicine, Miami, FL, 5Methodist University Hospital, Memphis, TN

    *Purpose: Transplantation of kidneys from deceased donors with hepatitis C virus (HCV) infection into HCV-negative recipients has become more common, but some studies have suggested…
  • 2021 American Transplant Congress

    Cleveland Clinic Experience with Cadaveric Uterus Transplant

    L. Del Prete1, C. Quintini1, K. Hashimoto1, B. Eghtesad1, G. D'Amico1, C. Kwon1, D. Priebe1, E. Richards1, S. Ricci1, U. Perni1, C. Ferrando1, A. Chiesa-Vottero1, S. Mawhorter1, N. Yeaney1, R. Farrell1, R. Flyckt2, C. Miller1, T. Falcone1, A. Tzakis1

    1Cleveland Clinic, Cleveland, OH, 2University Hospital, Cleveland, OH

    *Purpose: Uterus transplantation (UTx) is the only treatment for women with uterine factor infertility (UFI). The majority of overall experience is from living donation. Little…
  • 2021 American Transplant Congress

    Primary Outcome of OPTIMAL: A Prospective Multicenter Trial of Immunosuppression Withdrawal (ISW) in Stable Adult Liver Transplant (LT) Recipients

    S. Chandran1, K. Mason2, L. F. Sun1, N. Tanimine3, M. DesMarais1, B. Burrell1, J. F. Markmann3

    1ITN, San Francisco, CA, 2Rho, Inc., Durham, NC, 3MGH, Boston, MA

    *Purpose: To identify clinical & mechanistic correlates of successful ISW and operational tolerance (OT) in a selected cohort of adult LT recipients.*Methods: The Immune Tolerance…
  • 2021 American Transplant Congress

    Compatible Paired Donation in Paired Kidney Exchange: A Look at the Road Not Taken

    G. Vranic, A. Gilbert, B. Thomas, S. Ghasemian, M. Cooper, J. Verbesey

    MedStar Georgetown Transplant Institute, Washington, DC

    *Purpose: Paired kidney exchange (PKE) offers incompatible donor-recipient pairs increased access to transplant. Compatible pairs are increasingly joining the PKE in an effort to find…
  • 2021 American Transplant Congress

    Impact of the Covid-19 Pandemic on Transplant Pharmacist Workforce

    J. Lyons1, K. Khalil2, J. J. Teuteberg3, E. J. Henricksen4

    1Department of Pharmacy, Loyola University Medical Center, Maywood, IL, 2Department of Pharmacy, NYU Langone Health, New York, NY, 3Medicine and Section of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support, Stanford University, Stanford, CA, 4Department of Transplant, Stanford Health Care, Stanford, CA

    *Purpose: Evaluate the impact of the COVID-19 pandemic on the transplant pharmacist workforce.*Methods: A voluntary survey open from August 18, 2020 to September 15, 2020…
  • 2021 American Transplant Congress

    Peri-operative Liver Transplant Anesthesia Practice Patterns in the United States

    C. Crouch1, A. Hendrickse1, W. Stoll2, C. Sullivan3, M. Kaufman4, E. Pivalizza5, D. Damian6, D. Sellers7, M. Little8, S. McCluskey7, S. Kumar9, L. De Marchi10, S. Sridhar5, T. Sakai6

    1Department of Anesthesiology, University of Colorado, Aurora, CO, 2Medical University of South Carolina, Charleston, SC, 3Emory University, Atlanta, GA, 4Lahey Health, Burlington, MA, 5University of Texas Health Science Center at Houston, Houston, TX, 6University of Pittsburgh, Pittsburgh, PA, 7University of Toronto, Toronto, ON, Canada, 8University of Texas Health Science Center San Antonio, San Antonio, TX, 9University of Michigan, Ann Arbor, MI, 10Georgetown University, Washington DC, DC

    *Purpose: Transplant anesthesiology is an evolving subspecialty and has not been the subject of an overall review of practice patterns in the United States since…
  • 2021 American Transplant Congress

    Lung Transplant Recipients Developing Early DSAs are Characterized by a Shift Towards Memory B Cells Directly After Transplantation

    S. Christoph1, A. Hitz1, R. Bellmàs Sanz1, J. Kühne1, B. Wiegmann2, F. Ius2, J. Salman2, E. Chichelnitskiy1, T. Siemeni2, W. Sommer3, A. Haverich2, G. Warnecke3, C. Falk1

    1Institute of Transplant Immunology, MHH, Hannover, Germany, 2Department of Cardiothoracic, Transplant and Vascular Surgery, MHH, Hannover, Germany, 3Department of Cardiac Surgery, University Hospital Heidelberg, Heidelberg, Germany

    *Purpose: After lung transplantation (LTx), the development of early donor HLA-specific antibodies (eDSA) is associated with antibody-mediated rejection (AMR) and poor graft survival. Since 2013,…
  • 2021 American Transplant Congress

    Patterns and Inhibition of Cell Death During Static Cold Storage of Human Kidneys

    J. R. DiRito1, G. Chickering2, J. T. Langford1, D. Stern1, S. Hosgood3, M. L. Nicholson3, E. Gavathiotis4, R. N. Kitsis5, M. Saltzman2, J. S. Pober6, G. T. Tietjen7

    1Surgery, Yale School of Medicine, New Haven, CT, 2Biomedical Engineering, Yale University, New Haven, CT, 3Surgery, University of Cambridge, Cambridge, United Kingdom, 4Biochemistry and Medicine, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY, 5Surgery, Albert Einstein College of Medicine, Bronx, NY, 6Immunobiology, Yale University, New Haven, CT, 7Surgery and Biomedical Engineering, Yale School of Medicine, New Haven, CT

    *Purpose: As the donor population continues to age and accumulate co-morbidities, more marginal kidneys are being retrieved for transplantation. However, estimates suggest that more than…
  • 2021 American Transplant Congress

    Microbial Signatures Promote Antibiotic-Mediated Alleviation of Peritransplant Liver Damage in Mouse Recipients

    K. J. Dery1, S. Kageyama1, H. Hirao1, H. Kojima1, K. Kadono1, T. Dong2, J. W. Kupiec-Weglinski1

    1The Dumont-UCLA Transplantation Center, Los Angeles, CA, 2Department of Medicine, Vatche & Tamar Manoukian Division of Digestive Diseases, UCLA, Los Angeles, CA

    *Purpose: Although recent evidence shows that modifications of gut microbiota by antibiotics (Abx) influences liver allograft function, its compositional role in orthotopic liver transplantation (OLT)…
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