ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Potential Mechanism Involving Regulatory T Cells in Induction of Tolerance in Mouse Vascularized Composite Allotransplantation Under Combined Costimulation Blockade.

    M. Anggelia,1,2 Y.-Y. Huang,3 W.-Y. Chuang,4 H.-Y. Cheng,1 G. Brandacher,5 F.-C. Wei,1,2 C.-H. Lin.1,2

    1PRS, Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 2Chang Gung Medical College and Chang Gung University, Taoyuan, Taiwan; 3Nephrology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 4Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 5Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD

    Background: Role of Regulatory T cells in vascularized composite allotransplantation (VCA) remains to be elucidated. In this study, we investigate potential mechanism involved in Tregs…
  • 2017 American Transplant Congress

    Increase in Post-Transplant Mortality Under KAS.

    A. Massie, J. Garonzik-Wang, D. Segev.

    JHU, Baltimore

    Following implementation of the Kidney Allocation System (KAS), a major change to deceased donor kidney allocation in December 2014, transplantation rates increased for African-Americans and…
  • 2017 American Transplant Congress

    Organs with Extended Cold Ischemia Time May Offer Aged Kidney Transplant Recipients New Options in an Expanded Donor Pool.

    M. Postalcioglu,1 B. Byun,1 A. Kaze,2 A. Siedlecki,1 E. Milford,2 R. Abdi.1

    1Transplantation Research Center, Brigham and Women's Hospital, Boston, MA; 2Renal Division, Brigham and Women's Hospital, Boston, MA

    Using data from the largest cohort of renal transplants, the aim of this study was to examine the effects of cold ischemia times (CIT) on…
  • 2017 American Transplant Congress

    A Multi-Center Experience of Direct Acting Anti-Viral Agents in HCV Positive Patients Receiving HCV Positive Livers.

    N. Kapila,1 B. Zervos,2 B. Ismail,1 C. Lindenmeyer,3 V. Sanghi,3 K. Menon,3 G. Schnickel,2 J. Rivas,2 D. Reino,2 A. Tzakis.2

    1Gastroenterology, Cleveland Clinic, Weston, FL; 2Transplant, Cleveland Clinic, Weston, FL; 3Gastroenterology, Cleveland Clinic, Cleveland, OH

    Background: HCV cirrhosis is the leading indication for liver transplantation in the U.S. The development of direct acting anti-viral agents (DAAs) has changed the approach…
  • 2017 American Transplant Congress

    Impact of Ritonavir on Graft Function in Human Immunodeficiency Virus Infected Kidney Transplant Recipients.

    K. Roach, E. Meredith, M. Lyon.

    Emory University Hospital, Atlanta, GA

    Purpose: The purpose of this study was to determine the difference in 6 and 12 month graft function between patients with human immunodeficiency virus (HIV)…
  • 2017 American Transplant Congress

    De Novo DSA with T Cell Mediated Rejection (TCMR) Leads to Early Allograft Scarring and Dysfunction.

    A. Cherukuri, A. Sharma, M. Mangiola, P. Sood, P. Randhawa, A. Zeevi, R. Mehta, S. Hariharan.

    UPMC, Pittsburgh

    Detection of de novo DSA is associated with adverse outcomes in kidney transplant recipients (KTRs). The relationship between de novo DSA and subsequent TCMR and…
  • 2017 American Transplant Congress

    A Molecular Signature Characterized by Dominance of Negative Regulation over Cytotoxic Effectors in Tolerant Kidney Allograft Recipients.

    J. Lee,1 J. Leventhal,2 C. Li,1 A. Katapodis,3 S. Ildstad,4 M. Suthanthiran.1

    1Medicine, Weill Cornell, NY, NY; 2Surgery, Northwestern Medicine, Chicago, IL; 3Novartis, Basel, Switzerland; 4Regenerex, Louisville, KY

    Introduction. Development of tolerance biomarkers is important for interrogating the in-vivo immune status of patients entered in clinical trials of tolerance.Methods. To determine the feasibility…
  • 2017 American Transplant Congress

    Treating Ischemically Damaged Porcine Kidneys with Mesenchymal Stromal Cells During Normothermic Machine Perfusion.

    M. Pool,1 J. Sierra Parraga,2 M. Roemeling-van Rhijn,3 M. Reinders,4 M. Hoogduijn,2 R. Ploeg,1,5 H. Leuvenink,1 C. Moers.

    1Surgery, UMCG, Groningen, Netherlands; 2Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands; 3Internal Medicine, UMCG, Groningen, Netherlands; 4Nephrology, LUMC, Leiden, Netherlands; 5Oxford Transplant Centre, University of Oxford, Oxford, United Kingdom

    Normothermic machine perfusion (NMP) could provide superior organ preservation and offers the unique opportunity for interventions to an isolated kidney prior to transplantation. There is…
  • 2017 American Transplant Congress

    Hepatitis B Virus Infection Is Associated with Recurrent Nephropathy After Kidney Transplantation.

    G. Chen, C. Wang, Z. Wu, C. Wang, J. Qiu, L. Chen.

    Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

    Background Hepatitis B virus(HBV) infection can cause HBV associated nephropathy, and is one of the major reasons for secondary nephropathy. We carried out a retrospective…
  • 2017 American Transplant Congress

    Post-Donation Experiences of Non-Directed (Altruistic) Living Kidney Donors in the United States.

    A. Maghen,1 G. Vargas,1 S. Connor,1 S. Nassiri,1 E. Hicks,2 L. Kwan,1 S. Maliski,3 J. Veale.

    1Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA; 2Oregon Health and Science University, Portland, OR; 3University of Kansas Medical Center School of Nursing, Kansas City, KS

    A. Non-directed donors (NDDs) can potentially help alleviate the overburdened kidney transplant waiting list while also improve the quality of life for patients with end-stage…
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