ATC Abstracts

American Transplant Congress abstracts

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  • 2017 American Transplant Congress

    Biological Interplay Between Circulating HLA-sp Alloreactive Memory B-Cells and Long-Lived Plasma Cells in Kidney Transplant Patients Undergoing Chronic ABMR.

    S. Luque,2 M. Lúcia,4 M. Jarque,2 E. Crespo,2 E. Melilli,1 J. Martorell,3 J. Cruzado,1,2 J. Torras,1,2 J. Grinyó,1,2 O. Bestard.1,2

    1Kidney Transplant Unit, Bellvitge University Hospital, Barcelona, Spain; 2Experimental Nephrology Laboratory, IDIBELL, Barcelona, Spain; 3Immunogenetics Laboratory, Hospital Clínic, Barcelona, Spain; 4Transplant Immunology, School of Medicine, Stanford

    Alloreactive humoral responses are one of the main causes of immune-mediated allograft injury in kidney transplantation. Different biological compartments are involved in the generation and…
  • 2017 American Transplant Congress

    Sirolimus Prolonged Survival After Living Donor Liver Transplantation for HCC Beynd Milan Criteria; Outcome of a Multicenter Prospective Randomized Phase II Trial (ClinicalTrials.gov Identifier: NCT01374750).

    K.-W. Lee,1 S.-H. Kim,2 N.-J. Yi,1 S.-K. Hong,1 G. Yoon,1 H. Kim,1 D. Oh,1 S.-S. Han,2 S.-J. Park,2 K.-S. Suh.1

    1Department of Surgery, Seoul National University, Seoul, Republic of Korea; 2Center for Liver Cancer, National Cancer Center, Goyangsi, Republic of Korea

    Background:It is unclear whether the reported benefit of mTORi in LT for HCC is from direct effect of mTOR inhibitors. We aimed to compare directly…
  • 2017 American Transplant Congress

    Autophagy Regulates LG3 Maturation and Export in Apoptotic Exosome-Like Vesicles.

    D. Beillevaire,1,2,4 M. Francis,1,2,4 G. Diane,2 B. Éric,3,4 D. Mélanie,1,2,4 H. Marie-Josée.1,2,4

    1CRCHUM, Montréal, Canada; 2Université de Montréal, Montréal, Canada; 3CHUL, Québec, Canada; 4CNTRP, Edmonton, Canada

    Background: Autoantibodies to apoptotic antigens such as LG3 – a C-terminal fragment of perlecan– are present pre-transplantation and contribute to organ rejection in renal transplant…
  • 2017 American Transplant Congress

    Post-Donation Remaining Donor Kidney Function as Measured by CKD-EPI Formula at 2 Years Correlates and Is Predicted by Remaining Donor Kidney Volume.

    S. Hussain, A. Diez, A. Khalil, M. Yaqub, D. Mishear, T. Taber, O. Adebiyi, C. Sundaram, W. Goggins, J. Powelson, A. Sharfuddin.

    Indiana University School of Medicine, Indianapolis

    Aim: The aim of our study was to evaluate whether preserved kidney volume correlates with and can predict donor renal function at 2-years post-donation using…
  • 2017 American Transplant Congress

    De Novo Use of Everolimus Reduces Late-Onset Cytomegalovirus Primary Disease Occurring After Antiviral Prophylaxis Discontinuation in Kidney Transplant Recipients.

    A. Devresse,1 V. Avettand-Fenoel,2 A. Scemla,3 L. Morin,3 X. Lebreton,3 C. Tinel,3 L. Amrouche,3 L. Lamhaut,4 M.-O. Timsit,5 J. Zuber,3 C. Legendre,3 D. Anglicheau.3

    1Nephrology Unit, Cliniques Universitaires Saint-Luc, Brussels, Belgium; 2Virology Unit, Hôpital Necker-Enfants Malades, AP-HP, Paris, France; 3Kidney Transplantation and Intensive Care Unit, Hôpital Necker-Enfants Malades, AP-HP, Paris, France; 4Anesthesia Unit, Hôpital Necker-Enfants Malades, AP-HP, Paris, France; 5Urology Unit, Hôpital Necker-Enfants Malades, AP-HP, Paris, France

    Background: Donor (D)+/recipient (R)- serostatus is critically associated with an higher risk of cytomegalovirus (CMV) infection and disease. Antiviral prophylaxis is conventionally used in such…
  • 2017 American Transplant Congress

    The Impact of Social Support on Kidney Transplant Listing Decisions: Results from a Discrete Choice Experiment.

    K. Ladin,1,2 J. Emerson,2 Z. Butt, E. Gordon, D. Hanto, T. Lavelle.2

    1Occupational Therapy, Tufts University, Medford, MA; 2Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA

    Background: Although the Centers for Medicare and Medicaid Services require that social support be used to determine transplant eligibility, guidance is vague and centers vary…
  • 2017 American Transplant Congress

    A Prospective Iterative Trial of Carfizomib-Based Desensitization Trial: Initial Comparative Observations.

    S. Tremblay,1 A. Shields,1,2 R. Alloway,1 P. Brailey,1 A. Leino,1 A. Lichvar,1 B. Abu Jawdeh,1 J. Driscoll,1 A. Girnita,1 E. Woodle.1

    1U of Cincinnati, Cincinnati; 2Christ Hospital, Cincinnati

    Carfilzomib (CFZ) is a 2nd generation proteasome inhibitor different form bortezomib in that it irreversibly disables 20s and 26s proteasomes.Results from the first 2 phases…
  • 2017 American Transplant Congress

    Waitlist Desensitization and the Rate of Deceased Donor Kidney Transplantation After Implementation of the Kidney Allocation System.

    E. Huang, S. Jordan, R. Najjar, J. Choi, A. Peng, A. Vo.

    Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA

    Background:At Cedars Sinai Medical Center (CSMC), candidates with calculated panel reactive antibodies (cPRA) ≥30% (based on unacceptable antigens with MFI≥15,000) are desensitized while awaiting transplant.…
  • 2017 American Transplant Congress

    Tacrolimus Trough Concentration Variability and Disparities in African American Kidney Transplantation.

    D. Taber, Z. Su, A. Posadas, M. Gebregziabher, L. Egede, D. Dubay, J. McGillicuddy, C. Bratton, S. Nadig, K. Chavin, P. Baliga.

    MUSC, Charleston, SC

    Low tacrolimus (FK) trough concentrations have been associated with higher risk of acute rejection, particularly within African-American (AA) kidney transplant recipients; less is known about…
  • 2017 American Transplant Congress

    Circulating Exosomes Isolated from Human Lung Transplant Recipients with Rejection Are Immunogenic and Induce Antibodies to Lung Associated Self-Antigens, Kα1 Tubulin and Collagen-V.

    M. Gunasekaran, M. Sharma, S. Bansal, S. Biswas Roy, R. Walia, R. Bremner, M. Smith, T. Mohanakumar.

    Norton Thoracic Institute, St. Joseph's Hospital and Med Center, Phoenix

    Background: Exosomes isolated from acute and chronic rejections in lung transplant recipients (LTxR) demonstrated surface expression of mismatched donor human leukocyte antigen and lung associated…
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