2017 American Transplant Congress
Pre-Transplant Circulating TNFR2+ Regulatory T Cells Predict Acute Rejection within the First 6 Months After Kidney Transplantation.
Background: Acute rejection (AR) mostly occurs during the first 6 months after kidney transplantation and contributes importantly to graft loss. Diagnosis relies on changes in…2017 American Transplant Congress
Molecular Analysis of Acute Rejection in Formalin-Fixed Paraffin-Embedded Clinical Face Transplant Biopsies.
1Brigham and Women's Hospital, Boston, MA; 2Harvard T.H. Chan School of Publich Health, Boston
BackgroundDiagnosis of acute rejection in face transplants relies on the histological evaluation of allograft skin biopsies using BANFF classification, an approach with significant limitations including…2017 American Transplant Congress
Necroptotic Cellular Death Modulates TNFα Mediated Inflammation and Cardiac Allograft Rejection in Mice.
Immunology Institute, Icahn School of Medicine at Mount Sinai, NYC, NY
While graft injury following cold ischemia reperfusion (IR) can accelerate graft rejection, mechanisms are incompletely understood. Evidence indicates that posttransplant IR injury is associated with…2017 American Transplant Congress
A Search for a Biomarker Which Predicts Belatacept-Resistant Rejection.
Belatacept, an inhibitor of the CD28-CD80/86 costimulatory pathway, has been associated with a higher acute rejection risk than ciclosporin. We sought to identify a biomarker…2017 American Transplant Congress
A Multi-Center Experience of Direct Acting Anti-Viral Agents in HCV Positive Patients Receiving HCV Positive Livers.
Background: HCV cirrhosis is the leading indication for liver transplantation in the U.S. The development of direct acting anti-viral agents (DAAs) has changed the approach…2017 American Transplant Congress
Impact of Ritonavir on Graft Function in Human Immunodeficiency Virus Infected Kidney Transplant Recipients.
Emory University Hospital, Atlanta, GA
Purpose: The purpose of this study was to determine the difference in 6 and 12 month graft function between patients with human immunodeficiency virus (HIV)…2017 American Transplant Congress
De Novo DSA with T Cell Mediated Rejection (TCMR) Leads to Early Allograft Scarring and Dysfunction.
Detection of de novo DSA is associated with adverse outcomes in kidney transplant recipients (KTRs). The relationship between de novo DSA and subsequent TCMR and…2017 American Transplant Congress
A Molecular Signature Characterized by Dominance of Negative Regulation over Cytotoxic Effectors in Tolerant Kidney Allograft Recipients.
Introduction. Development of tolerance biomarkers is important for interrogating the in-vivo immune status of patients entered in clinical trials of tolerance.Methods. To determine the feasibility…2017 American Transplant Congress
Treating Ischemically Damaged Porcine Kidneys with Mesenchymal Stromal Cells During Normothermic Machine Perfusion.
Normothermic machine perfusion (NMP) could provide superior organ preservation and offers the unique opportunity for interventions to an isolated kidney prior to transplantation. There is…2017 American Transplant Congress
Hepatitis B Virus Infection Is Associated with Recurrent Nephropathy After Kidney Transplantation.
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Background Hepatitis B virus(HBV) infection can cause HBV associated nephropathy, and is one of the major reasons for secondary nephropathy. We carried out a retrospective…
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