Am J Transplant, Volume 16, Suppl 3 Archives - Page 31 of 180 - ATC Abstracts

2016 American Transplant Congress
RNAseq Transcriptome Analysis of Bone Marrow CD138⁺ Plasma Cell Responses to Carfilzomib Monotherapy Desensitization.
J. Driscoll, B. Aronow, S. Tremblay, R. Alloway, E. Woodle.
Medicine, Surgery, Biomedical Informatics, U of Cincinnati, Cincinnati Children's, Cincinnati, OH.
Purpose: Prior studies indicate that bone marrow resident plasma cells (BMRPCs) demonstrate varying sensitivity to proteasome inhibition (PI). Effects of carfilzomib (CFZ) monotherapy desensitization on…
2016 American Transplant Congress
Activated Cytoprotective Mechanisms in DBD Kidneys Correlate with Kidney Function in Transplant Recipients: A Study Using Clinical Samples from the UK QUOD Biobank.
M. Kaisar,¹ L. van Dullemen,² Z. Akhtar,¹ M. Lo Faro,¹ H. Huang,¹ H. Leuvenink,² B. Kessler,¹ R. Ploeg.¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ²UMCG, UMCG, Groningen, Netherlands.
The onset of abnormal pathophysiological changes following brain death adversely impact kidney function following transplantation. Understanding the biological mechanisms that affect kidney quality will allow…
2016 American Transplant Congress
Early Conversion to Everolimus in De Novo Renal Transplant Recipients: Incidence of Viral Infections in the Randomized-Controlled ELEVATE Study.
H. Hirsch,¹ J. De Fijter,¹ M. van der Giet,¹ M. Zeier,¹ J. Pascual,¹ Y. Avihingsanon,¹ P. Lopez,² J. Aguilar-Sanchez,² J. Kochuparampil,² Z. Wang,³ H. Holdaas,¹ J. Cruzado.¹
¹ELEVATE Study Group, Basel, Switzerland; ²Novartis, Basel, Switzerland; ³Novartis Pharmaceutical Corporation, East Hanover.
BackgroundCytomegalovirus (CMV) and BK polyomavirus (BKPyV) infections are independent risk factors for acute rejection and graft loss. Early conversion from calcineurin inhibitors (CNIs) to everolimus…
2016 American Transplant Congress
Assessing Return of CMV Specific Cellular Immunity Using the T-SPOT.CMV Soon After Kidney Transplant with Thymoglobulin.
C. Kotton.
Infectious Disease, Massachusetts General Hospital, Boston, MA.
Background: We do not currently have sufficient predictive tools to determine risk of CMV infection after organ transplantation. Recent data suggest that assays of the…
2016 American Transplant Congress
Hif-1α Stabilization in the Recipient Accelerates Cardiac Allograft Rejection.
Z. Ilyas, M. DeBerge, S. Dehn, J.-J. Wang, Z. Zhang, E. Thorp, M. Ansari.
Northwestern University, Chicago.
Introduction: Increased Hif-1α mRNA expression in deceased-donor organ transplant tissue prior to or soon after transplantation significantly correlated with primary graft dysfunction. HIF-1α is positioned…
2016 American Transplant Congress
Receptor Tyrosine Kinase Mer Mediates Expansion of MDSCs Critical for Transplantation Tolerance.
L. Zhang,¹ M. DeBerge,² X. Zhang,³ J. Wang,³ Z. Zhang,³ E. Thorp,² X. Luo.^1,2,3
¹Medicine, Northwestern University, Chicago, IL; ²Microbiology and Immunology, Northwestern University, Chicago, IL; ³Comprehensive Transplant Center, Northwestern University, Chicago, IL.
Introduction: The TAM (Tyro3, Axl and Mer) receptor tyrosine kinases (RTKs) mediate homeostatic phagocytosis of apoptotic cells, and transmit regulatory signals that modulate immune response.…
2016 American Transplant Congress
Expansion of Regulatory B-Cells and Their Potential Role in Transplantation Tolerance.
B. Amundsen, H. Deirawan, J. Kim, J. Markmann.
Massachusetts General Hospital, Boston, MA.
IntroductionRegulatory B (Bregs) cells, B cells which produce IL-10, have been shown to play a critical role in immune homeostasis and autoimmunity models. Despite the…
2016 American Transplant Congress
Role of NRP1 in CD4+ T Cell Allo-Activation.
E. Lee, H. Kim, G. Demirci.
Department of Surgery, Boston Children's Hospital, Boston, MA.
Introduction: Neuropilin-1 (NRP1) is a transmembrane glycoprotein that functions as a co-receptor for class III/IV semaphorins, VEGF, and several other growth factors. NRP1 has been…
2016 American Transplant Congress
Better Long-Term Renal Function with Lower Incidence of Acute Rejection and Lower CMV Infection in Renal Transplant Patients Treated with a Combination of Tacrolimus and Everolimus.
G. Spagnoletti, M. Salerno, V. Bianchi, N. Silvestrini, F. Apponi, J. Romagnoli, F. Citterio.
Surgery - Renal Transplant Unit, Università Cattolica del Sacro Cuore, Rome, Italy.
Introduction. Recent clinical trials have shown that the combination of CNIs with Everolimus (EVE) allows CNIs minimization, which may positively impact on chronic nephrotoxicity. Aim…
2016 American Transplant Congress
Hospitalizations for Cardiovascular Disease After Liver Transplantation in the United States: Epidemiology, Outcomes, and Costs.
A. Mathur, Y.-H. Chang, D. Steidley, N. Khurmi, N. Katariya, A. Singer, W. Hewitt, K. Reddy, A. Moss.
Transplant Center, Mayo Clinic, Phoenix.
Background: Cardiovascular disease (CVD) is a leading cause of post-liver transplant death, and variable care patterns may affect outcomes. We aimed to describe epidemiology, outcomes,…