ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Angiotensin II Blockade and Fibroblast Growth Factor-23 in Stable Kidney Transplant Recipients.

O. Sanchez, S. Reule, S. Li, D. Berglund, R. Spong, H. Ibrahim.

U of MN, Mpls.

Meeting: 2016 American Transplant Congress

Abstract number: D258

Keywords: Glomerular filtration rate (GFR), Kidney transplantation

Session Information

Date: Tuesday, June 14, 2016

Session Name: Poster Session D: Poster Session II: Kidney Complications-Other

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Halls C&D

Related Abstracts
  • Pulse Pressure and GFR Decay in Kidney Transplant Recipients.
  • Predictors of Serum Uric Acid and Its Impact on Kidney Structure and Function: A Five Year Prospective Study

Introduction: FGF-23 has been linked to allograft failure. However, careful serial profiling of FGF-23 has not been done. Therefore, we measured FGF-23 levels in recipients who participated in the ABCAN Trial funded by the NIH.

Methods: This is a post-hoc analysis of the 154 kidney transplant recipients who were randomized to losartan (100 mg daily) vs. placebo shortly after transplantation. Subjects underwent annual iothalamate GFR for 5 years in addition to allograft biopsy at study entry and exit. The primary endpoint of the trial was doubling of cortical interstitium volume expansion from baseline to 5 years or ESRD from IF/TA. The main result showed a modest protective effect with losartan (p = 0.08).

Results: FGF-23 was measured at baseline and year 5. Cross sectional unadjusted analysis of FGF-23 at baseline showed that it was not associated with age, systolic or diastolic blood pressures, urinary protein or fraction of renal cortical volume occupied by interstitium. However, FGF-23 was positively associated with creatinine (r = 0.42, p < 0.0001), uric acid (r = 0.22, p = 0.02) and inversely associated with iothalamate GFR (r = -0.23, p = 0.01). Figure 1 shows a marginal sex*time interaction in FGF-23 (p <0.05) indicating at baseline FGF-23 is higher in females, but at year 5 this difference disappeared (p = 0.50). FGF-23 doubled in the placebo group while it declined with losartan.

Conclusion: FGF-23 levels decline with angiotensin II blockade and its level was inversely associated with iothalamate GFR. Unfortunately, we do not have data on the different components of this axis such as parathyroid hormone and serum calcium and phosphate.

CITATION INFORMATION: Sanchez O, Reule S, Li S, Berglund D, Spong R, Ibrahim H. Angiotensin II Blockade and Fibroblast Growth Factor-23 in Stable Kidney Transplant Recipients. Am J Transplant. 2016;16 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Sanchez O, Reule S, Li S, Berglund D, Spong R, Ibrahim H. Angiotensin II Blockade and Fibroblast Growth Factor-23 in Stable Kidney Transplant Recipients. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/angiotensin-ii-blockade-and-fibroblast-growth-factor-23-in-stable-kidney-transplant-recipients/. Accessed March 4, 2021.

« Back to 2016 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Penis Transplantation: First U.S. Experience.
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.