Am J Transplant, Volume 16, Suppl 3 Archives - Page 161 of 180 - ATC Abstracts

2016 American Transplant Congress
Association Between GFR Decline and Long Term Outcome in Renal Transplantation.
A. Delay,¹ O. Moranne,² N. Maillard,¹ E. Alamartine,¹ C. Mariat.¹
¹Nephrology Department, CHU, Saint Etienne, France; ²Nephrology Department, CHU, Nimes, France.
In renal transplantation, GFR decline is strongly associated to graft failure and patient death and thus could be an interesting proxy for clinical research. GFR…
2016 American Transplant Congress
Chemoprevention of Cutaneous Squamous Cell Carcinoma in Renal Transplant Recipients: A Case-Controlled Analysis.
R. Anand, R. Hung, S. Frame, K. Bramham, M. Wain, A. Cronin.
Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom.
Organ transplant recipients are up to 200 times more likely to develop cutaneous squamous cell carcinoma (SCC) than age-matched general populations. Systemic retinoids, such as…
2016 American Transplant Congress
Donor Risk Index for Intestinal & Multi-Visceral Transplantation.
G. Zeng,¹ M. Chen,² X. Zhao,³ D. Landsittel,² H. Sogawa.⁴
¹Department of Pathology, The Thomas E Starzl Transplantation Institute, Pittsburgh, PA; ²Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, PA; ³Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China; ⁴Multi-Organ Transplant & Hepatobiliary, Westchester Medical Center, Valhalla, NY.
Background: The Donor Risk Index and the Kidney Donor Profile Index (KDPI) have been utilized for liver and kidney transplantation in clinical and research setting.…
2016 American Transplant Congress
Eomesodermin Expression by CD8+ Alloreactive T Cells in Human and Nonhuman Primate Allograft Recipients.
A. Perez-Gutierrez, L. Lu, A. Zahorchak, Y. Ono, A. Thomson, M. Ezzelarab.
Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
Background:The transcription factor Eomesodermin (Eomes) is critical in the maintenance of antigen-specific memory T cells (Tmem). We have shown previously that prolonged kidney allograft survival…
2016 American Transplant Congress
Belatacept Immunotherapy Is Not Augmented by Blockade of Activated LFA-1 in a Nonhuman Primate Renal Transplant Model.
K. Samy,¹ M. Mulvihill,¹ B. Collins,¹ D. Lo,² M. Song,¹ F. Leopardi,¹ A. Kirk.^1,2
¹Department of Surgery, Duke University Medical Center, Durham, NC; ²Emory University, Atlanta, GA.
Purpose: Belatacept specifically targets de novo alloimmune responses without off target side effects. However, resistant alloreactive memory T cells have complicated its use. LFA-1 therapy…
2016 American Transplant Congress
One-Year Graft Loss Risk in Kidney Transplants – A Big Data Approach.
T. Srinivas, D. Taber, J. Zhang, Z. Su, J. Marsden, A. Tripathi, W. Moran, P. Mauldin.
MUSC, Charleston, SC; IBM Corp., Armonk.
Background Predictive models using national data are limited by lack of evolving patient level data. A Big Data approach using both static and dynamic variables…
2016 American Transplant Congress
Similar Kidney Allograft and Patient Survival in Native Americans Despite Lower Rates of Living Donation and Longer Wait on the Deceased Donor List.
H. Khamash,¹ K. Reddy,² H. Chakkera,¹ J. Huskey,¹ S. Sukumaran-Nair,¹ A. Mathur,² A. Moss,² N. Katariya,² A. Singer,² R. Heilman.¹
¹Nephrology, Mayo Clinic Arizona, Phoenix; ²Transplant Surgery, Mayo Clinic Arizona, Phoenix.
Previous studies have shown that Native Americans (NAs) have decreased access and inferior outcomes following kidney transplantation. Reviewing our center's experience we wanted to assess…
2016 American Transplant Congress
Impediments to Timely Listing for HIV+ Patients Being Evaluated for Kidney Transplantation.
D. Lee,¹ A. Aldea,¹ M. Harhay,² S. Akshay,² G. Malat,³ N. Law,¹ S. DeBellis,² T. Bias,¹ S. Boyle,² K. Ranganna,² A. Doyle.²
¹Division of Infectious Diseases and HIV Medicine, Drexel University, Philadelphia; ²Division of Nephrology, Drexel University, Philadelphia; ³Department of Surgery, Drexel University, Philadelphia.
Introduction:HIV+ individuals can be transplanted safely and effectively but face additional barriers in evaluation and listing.MethodsWe performed a single center chart review of all HIV+…
2016 American Transplant Congress
The Immunologic Profile of Brain Death in Humans: A Whole-Body Analysis.
D. Carpenter,^1,2 N. Matsuoka,¹ J. Thome,^1,3 T. Granot,^1,3 C. Gordon,^1,3 B. Kumar,^1,3 T. Senda,^1,3 M. Miron,^1,3 J. Weiner,² A. Griesemer,^1,2 D. Farber.^1,2,3
¹Columbia Center for Translational Immunology, Columbia University Medical Center, New York City, NY; ²Surgery, Columbia University Medical Center, New York City, NY; ³Microbiology and Immunology, Columbia University Medical Center, New York City, NY.
Transplantation outcomes are believed to be influenced by a generalized inflammatory state caused by brain death itself or events in the peri-transplant period. Studies on…
2016 American Transplant Congress
Stratification of Kidney Transplant Recipients into Those with Low and High Alloreactive T-Cells May Allow Safe Conversion to mTOR-Inhibitor-Based Immunosuppression.
T. Schachtner,^1,2 M. Stein,² P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapies, Charite Campus Virchow Clinic, Berlin, Germany.
ZEUS and Herakles study randomized kidney transplant recipients (KTRs) to either continue cyclosporine or convert to everolimus posttransplantation with favorable long-term outcomes in the conversion…