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The Relationship Between Kidney Donor Profile Index and Six Month eGFR in Deceased Donor Recipients.

D. Keith, A. Nishio Lucar, G. Vranic.

Division of Nephrology, University of Virginia, Charlottesville, VA.

Meeting: 2016 American Transplant Congress

Abstract number: 560

Keywords: Donors, Glomerular filtration rate (GFR), Kidney transplantation, marginal

Session Information

Date: Tuesday, June 14, 2016

Session Name: Concurrent Session: The High KDPI Kidney: Outcomes and Optimal Utilization

Session Time: 4:30pm-6:00pm

 Presentation Time: 4:42pm-4:54pm

Location: Ballroom C

Related Abstracts
  • Kidney Donor Profile Index and Recipient BMI Are Potent Predictors of Six Month Deceased Donor eGFR as Opposed to EPTS.
  • High Kidney Donor Profile Index (KDPI) Correlates With Calculated Pulsatile Perfusion (PP) Resistance Index (RI) and Delayed Graft Function (DGF)

Kidney function, as measured by GFR, at 6 months post-kidney transplant is a powerful predictor of long-term post-transplant outcomes. This study sought to understand the relationship between kidney donor profile index (KDPI) of the donor and GFR at six months in the recipient.

All adult deceased donor kidney recipients with six months of graft survival and a six month follow-up creatinine transplanted between January 1, 2005 and December 31, 2012 were included in the analysis. 74,387 recipients had 6 months of graft survival. Of these recipients, 96.9% (n=72,046) had a follow-up creatinine at six months. eGFR was calculated using the CKD EPI equation.

A linear relationship existed between median eGFR at six months and KDPI of the donor. Linear regression analysis showed for every 10% increase in KDPI the median eGFR dropped 3.1 ml/min/1.72m2.

   Coefficient in ml/min/1.72m2  Standard Error  Significance
 Constant  74.09    0.66    <0.001 
 KDPI per percent -0.31   0.00  <0.001
 Pediatric en bloc kidney transplant  26.44  0.59  <0.001
 Delay graft function  -4.82  0.17  <0.001
 Acute rejection in first six months  -9.45  0.25  <0.001
 Discharge immunosuppression      
    Tac/MPA  1.76  0.65  0.006
    CSA/MPA  -2.97  0.71  <0.001
    CNI/mTOR  -4.16  0.78  <0.001
    CNI/AZA  0.07  1.20  0.952
    Other Combination  -0.84   0.69  0.226

Finally, we determined the eGFR distribution at six months based on the allocation KDPI groups (0-20%, 21-85% and 86-100%). The median eGFR was 68.7, 55.3 and 42.5 ml/min/1.72m2 respectively.

KDPI is a strong predictor of graft function at six months and is an important consideration when determining recipients of high KDPI organs.

CITATION INFORMATION: Keith D, Nishio Lucar A, Vranic G. The Relationship Between Kidney Donor Profile Index and Six Month eGFR in Deceased Donor Recipients. Am J Transplant. 2016;16 (suppl 3).

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To cite this abstract in AMA style:

Keith D, Lucar ANishio, Vranic G. The Relationship Between Kidney Donor Profile Index and Six Month eGFR in Deceased Donor Recipients. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/the-relationship-between-kidney-donor-profile-index-and-six-month-egfr-in-deceased-donor-recipients/. Accessed February 27, 2021.

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