Date: Monday, May 1, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
As the population ages and as the average age of liver transplant (LT) waitlist candidates increases, understanding of the trends and outcomes is imperative for clinical decision-making, appropriate referral for LT and post-LT care in older adults.
Older (age>=65) deceased donor liver-only recipients were identified using data from SRTR from 1/1/2003- 12/31/2015. We studied temporal changes in recipient, donor and LT characteristics along with mortality and death-censored graft loss. We used an adjusted Cox proportional hazards calculate adjusted changes in outcomes over time.
Since 2003, 7,694 older adults have received LTs. Older adults accounted for 19.0% of LT recipients in 2015 (N=1004), up from 9.1% (N=262) in 2003. Older recipients in 2015 were more likely to be female, African-American, and have a higher BMI and MELD compared to older recipients in 2003. Also, the indications for LT shifted to a higher prevalence of hepatitis C, non-alcoholic fatty liver, and hepatocellular carcinoma. Mortality for older LT recipients between 2012-2015 was 44% lower (HR: 0.56, 95%CI: 0.49-0.64, p<0.001) than between 2003-2006. All cause graft loss for older LT recipients between 2012-2015 was 43% lower (HR: 0.57, 95%CI: 0.50-0.66, p<0.001) than between 2003-2006. CONCLUSIONS
Despite a large increase in the number of older adults transplanted, a changing demographic of older LT recipients, and a higher MELD, mortality and graft loss have decreased substantially for older LT recipients over the past 10 years. These trends are important for consideration for LT referral and clinical decision-making in older adults.
CITATION INFORMATION: Haugen C, Huang Q, Pozo M, McAdams-DeMarco M, Segev D. Trends in Liver Transplantation Among Older Adults with ESLD. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Haugen C, Huang Q, Pozo M, McAdams-DeMarco M, Segev D. Trends in Liver Transplantation Among Older Adults with ESLD. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/trends-in-liver-transplantation-among-older-adults-with-esld/. Accessed December 7, 2019.
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