Articles tagged "Age factors"

2020 American Transplant Congress
Transition from Youth to Adult Care of Kidney Transplant Recipients: Single Center Experience
L. Ganesan, A. McGrath, K. Dahl, K. Dinello, A. Fong, L. Maestretti, M. Patton, P. Grimm, A. Chaudhuri
Pediatric Nephrology, Lucile Packard Children's Hospital, Stanford, CA
*Purpose: Transition of transplant recipients from youth to adult care has been a challenge for many. Starting in March 2017, Lucile Packard Children’s Hospital (LPCH)…
2020 American Transplant Congress
Managing the Road to Kidney Transplantation in the Elderly
R. S. Munjal, K. Kalra, A. Cherukuri, D. Jorgensen, S. Verma, P. Sood, R. Mehta, C. Puttarajappa, S. Hariharan, C. Wu
Nephrology, UPMC, Pittsburgh, PA
*Purpose: We hypothesize that careful patient selection and waitlist management minimizes the impact of advanced recipient age on kidney transplant outcomes.*Methods: A total of 3,521…
2020 American Transplant Congress
Outcome of Large Donor-Recipient Age Gap in Live-Donor Renal Transplant in Tacrolimus Era
K. Soliman¹, T. Fulop¹, M. Mohamed Ahmed¹, A. Osman², A. Posadas¹, M. Casey¹, V. Rao¹, V. Rohan³, D. Dubay³, S. Nadig³, H. Ali⁴
¹Medicine, Medical University of South Carolina, Charleston, SC, ²Medicine, Cairo University, Cairo, Egypt, ³Surgery, Medical University of South Carolina, Charleston, SC, ⁴Medicine, Royal Stoke University, Royal Stoke, United Kingdom
*Purpose: A large donor-to-recipient age gap among deceased-donor renal transplant (RT) patients leads to worse outcomes. However, the impact of this age gap among live-donor…
2020 American Transplant Congress
Age Mismatch between Donor and Recipient in Heart Transplant and its Effect on Mortality
A. Kumar¹, L. Bonell², M. Prikis¹
¹Internal Medicine, University of Vermont, Burlington, VT, ²Division of General Internal Medicine Research, University of Vermont, Burlington, VT
*Purpose: Increasing donor to recipient age difference has been shown to reduce survival in pediatric heart transplant population. However, the effect of age mismatch in…
2020 American Transplant Congress
Age- and Sex-Mediated Differences in T Lymphocyte Populations of Kidney Transplant Recipients
R. Dziarmaga¹, D. Ke¹, V. Phan², H. Cardinal³, R. Sapir-Pichhadze¹, C. A. Piccirillo¹, B. Mazer¹, B. Foster¹
¹Research Institute - McGill University Health Centre, Montreal, QC, Canada, ²Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada, ³Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada
*Purpose: Kidney allograft failure rates peak between 17 to 24 years of age and are higher in young female than male kidney transplant recipients (KTR).…
2020 American Transplant Congress
T Cell Hyporesponsiveness in Kidney Transplant Recipients is Associated with Urinary Tract Infections and Age of Kidney Transplant: Implications for Allograft Nephropathy
A. Assounga, S. Omarjee
Dept of Nephrology, University of KwaZulu-Natal, Durban, South Africa
*Purpose: Chronic allograft nephropathy is the main cause of kidney graft loss. With the use of potent immunosuppressive treatments, acute rejections are less and less…
2020 American Transplant Congress
Donor and Recipient Sex Affect Transplant Outcomes in an Age-Specific Fashion
R. Maenosono¹, Y. Nian¹, J. Iske¹, Y. Liu¹, H. Azuma², E. Milford³, S. G. Tullius¹
¹Division of Transplant Surgery, Brigham and Women's Hospital, Boston, MA, ²Urology, Osaka Medical College, Osaka, Japan, ³Renal Division, Brigham and Women's Hospital, Boston, MA
*Purpose: Donor and recipient sex impact transplant outcomes. The biology of sex-specific alloimmune responses has not been studied in detail.*Methods: Using clinical data from more…
2020 American Transplant Congress
Targeting CD4⁺ T Cell Metabolism Prolongs Graft Survival Age-Specifically
Y. Nian, J. Iske, K. Minami, R. Maenosono, T. Heinbokel, A. Elkhal, S. G. Tullius
Division of Transplant Surgery and Transplant Surgery Research Laboratory, Harvard Medical School, Boston, MA
*Purpose: If and how aging affects T-cell metabolism and alloimmune response is unclear. Here, we show that T-cell metabolism changes drastically in aging. Most notably,…
2020 American Transplant Congress
Serum αKlotho after Living Kidney Donation: A Systematic Review and Meta-Analysis
W. Cheungpasitporn¹, C. Thongprayoon², N. Leeaphorn³, M. A. Mao⁴, J. A. Neyra⁵
¹Nephrology, University of Mississippi Medical Center, Jackson, MS, ²Nephrology and Hypertension, Mayo Clinic, Rochester, MN, ³Renal Transplant Program, University of Missouri-Kansas City School of Medicine/Saint Luke's Health System, Kansas City, MO, ⁴Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL, ⁵Nephrology, University of Kentucky, Lexington, KY
*Purpose: αKlotho (klotho) is a known anti-aging protein that exerts diverse physiological effects. Defect in klotho gene expression in mice can result in a syndrome…
2020 American Transplant Congress
Older Livers Should Not Be Utilized in Pediatric Liver Transplantation
M. MacConmara, C. Feizpour, A. Aqul, D. Desai, P. Vagefi, S. Hanish, L. DeGregorio, C. S. Hwang
UT Southwestern, Dallas, TX
*Purpose: Organ scarcity in liver transplantation has required expansion of the acceptable criteria used for donor selection. The utilization of older donors (>60 years) has…