ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Single Center Experience of HLA-Related Donor Specific Antibody in Living Donor Liver Transplantation

H. Egawa,1 Y. Kotera,1 A. Ohmori,1 S. Yamashita,1 T. Kato,1 S. Nemoto,1 T. Ishizuka,2 M. Yamamoto.1

1Surgery, Tokyo Women's Medical University, Tokyo, Japan
2Clinical Laboratory, Tokyo Women's Medical University, Tokyo, Japan.

Meeting: 2018 American Transplant Congress

Abstract number: C210

Keywords: B cells, HLA antibodies, Immunosuppression, Liver transplantation

Session Information

Date: Monday, June 4, 2018

Session Name: Poster Session C: Liver: Immunosuppression and Rejection

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall 4EF

Related Abstracts
  • Pre-Operative Desensitization for Live Donor Liver Transplantation with Strong Donor-Specific Antibodies.
  • Mothers Are Often Sensitized and Sensitive: Antibody Mediated Rejection in Child to Mother Living Donor Liver Transplantation.

Although impact of donor specific antibody in liver transplantation has been recognized, significance of desensitization is not established yet. Our aim is to share our experience of desensitization using a regimen for ABO incompatible (ABO-I) liver transplantation. Among 61 adult living donor liver transplantation (LDLT) performed from August 2011 to October 2017, 11 patients had positive donor specific antibody (DSA) by single bead method (only Class I in 3, only Class II in 3, and both Classes I and II in 5 patients). Mean fluorescence Intensity (MFI) was greater 10,000 in 5 patients and less than 10,000 in 6 patients. Lymphocyte cytotoxic test (LCT) was positive in 4 of 5 patients with high MFI and negative in all 6 patients with low MFI. The 5 patients with high MFI (only Class I in 1 and both Classes I and II in 4) were treated with rituximab (500mg) 2 weeks prior to operation and splenectomy during transplantation and triple immunosuppression (Tacrolimus, Steroid, Mycophenolate). Class I DSA was turned to negative in 3 and decreased in 1 and LCT became negative in all. Class II DSA turned to negative in 3 and the MFI was increased from 11,000 up to 14,000 once and decreased to 4000 600 days after transplantation in another patient, and decreased around 8000 in the other patient. LCT turned to negative in all 6 patients with positive Class II DSA. Acute cellular rejection occurred and was successfully treated with steroid pulse in one patient. Massive necrosis or sclerosing cholangitis reported as antibody mediated rejection (AMR) or chronic rejection was not observed. Three of 5 patients with high MFI developed stenosis of biliary anastomosis requiring interventions (60%). In conclusion, desensitization using rituximab for ABO-I LT was feasible for LDLT with strongly positive HLA-related-DSA.

CITATION INFORMATION: Egawa H., Kotera Y., Ohmori A., Yamashita S., Kato T., Nemoto S., Ishizuka T., Yamamoto M. Single Center Experience of HLA-Related Donor Specific Antibody in Living Donor Liver Transplantation Am J Transplant. 2017;17 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Egawa H, Kotera Y, Ohmori A, Yamashita S, Kato T, Nemoto S, Ishizuka T, Yamamoto M. Single Center Experience of HLA-Related Donor Specific Antibody in Living Donor Liver Transplantation [abstract]. https://atcmeetingabstracts.com/abstract/single-center-experience-of-hla-related-donor-specific-antibody-in-living-donor-liver-transplantation/. Accessed January 19, 2021.

« Back to 2018 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Home
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Search
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.