ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Retrospective Cohort Study Concerning Efficacy and Safety of Bortezomib in Combination With Or Without Rituximab in Antibody Mediated Rejection in Renal Transplant Recipients

M. Duerr, N. Lachmann, K. Budde, J. Waiser.

Charité
Universitätsmedizin Berlin, Department of Nephrology, Berlin, Germany.

Meeting: 2015 American Transplant Congress

Abstract number: A108

Keywords: CD20, Graft survival, HLA antibodies

Session Information

Session Name: Poster Session A: Kidney Antibody Mediated Rejection

Session Type: Poster Session

Date: Saturday, May 2, 2015

Session Time: 5:30pm-7:30pm

 Presentation Time: 5:30pm-7:30pm

Location: Exhibit Hall E

Treatment of antibody-mediated rejection (AMR) in renal transplant (tx) patients (pts) is still challenging and long-term outcome remains unsatisfying. Because plasma cells (PCs) are crucial for donor specific HLA antibody (DSA) formation, targeting this cell population with bortezomib (BZ) is quite reasonable. Combination of BZ with the B-cell depleting rituximab (Ritux) may display synergistic effects on precursor and mature DSA producing cells.

The aim of this study was to evaluate the efficacy and safety of three different AMR therapy regimens with Ritux (n=12, group A), BZ (n=23, group B) or Ritux+BZ (n=10, group C).

45 tx pts (men:29) with graft dysfunction, DSA and biopsy proven AMR according to BANFF classification were included into the study, starting in 1/2005. All pts received steroid pulse and PPH (6x). In addition, group A received a fixed dose of Ritux 500mg and IVIG 30g. Group B received 1 cycle of BZ (1.3 mg/m2; day 1, 4, 8, 11) and IVIG (30g; n=11 or 1.5g/kg; n=12). Group C received a combination of Ritux 500mg and one cycle of BZ with high dose IVIG. Pts had a mean follow-up of 59 (SD+/-22.5) months (m).

Cumulative pt survival was 94.3% in the follow-up. One pt died due to unknown cause 23m after treatment (group A) and one pt died from MI 33m after AMR therapy (group B). In general, graft survival was inferior in group A (1/12; 8.3%) as compared to group B (9/23; 39.1%; p=0.04) and group C (6/10; 60%; p=0.02) at the end of follow-up time. However, between group B and C, no significant difference was seen concerning graft survival. Notably, in group C adverse events, in particular infections were more dominant compared to both other groups.

This retrospective cohort study demonstrated significantly better graft survival following treatment of AMR with BZ or Ritux+BZ compared to Ritux alone in the long-term follow-up. The additional use of Ritux in combination with BZ showed no additional effect, but an increased incidence of side effects. Further randomized trials need to be performed to obtain more data on such a synergistic approach.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Duerr M, Lachmann N, Budde K, Waiser J. Retrospective Cohort Study Concerning Efficacy and Safety of Bortezomib in Combination With Or Without Rituximab in Antibody Mediated Rejection in Renal Transplant Recipients [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/retrospective-cohort-study-concerning-efficacy-and-safety-of-bortezomib-in-combination-with-or-without-rituximab-in-antibody-mediated-rejection-in-renal-transplant-recipients/. Accessed May 30, 2025.

« Back to 2015 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences