2015 American Transplant Congress » Poster Session A: Kidney Antibody Mediated Rejection

Date: Saturday, May 2, 2015

Time: 5:30pm-7:30pm

Location: Exhibit Hall E

Session Type: Poster Session

Meeting: 2015 American Transplant Congress

5:30pm-7:30pm: “Unexpected” Positive Crossmatchs in Zero-HLA-A-B-DR Mismatched or HLA-DR-Matched Organs

K. Haarberg,¹ M. Cusick,¹ M. Abecassis,¹ A. Jaramillo,² B. Kaplan,³ A. Tambur.¹

5:30pm-7:30pm: A New Diagnostic and Pronostic Tool for Antibody Mediated Rejection in Kidney Transplantation: Intragraft Donor Specific Anti-HLA Antibodies Detection

J. Olagne,^1,2,3 A. Parissiadis,² S. Caillard,¹ N. Froelich,² L. Marcellin,³ C. Muller,¹ G. Gautier-Vargas,¹ P. Perrin,¹ L. Braun-Parvez,¹ F. Heibel,¹ C. Gachet,² B. Moulin.¹

5:30pm-7:30pm: A Novel DSA Flow Cytometer Crossmatch (DSA-FXM) to Eliminate Ambiguous Auto- and Allo-FXM Results

G. Chen, L. Lin, D. Tyan.

5:30pm-7:30pm: Angiotensin Receptor Antibody IgG1 Subclass Predicts Accelerated Graft Loss in Those Kidney Transplant Recipients Who Develop Biopsy Proven Transplant Glomerulopathy Irrespective of the Presence Or Absence of Donor Specific Anti HLA Antibodies

R. Carroll,¹ A. Phillippe,² D. Dragun,² T. Coates.¹

5:30pm-7:30pm: Antibodies Directed Against HLA-DQ Are Significantly Associated to Complement Activation In Vitro

J. Arreola-Guerra, A. de Santiago, A. Arvizu, N. Gonzalez-Tableros, M. Lopez, M. Vilatoba, L. Morales-Buenrostro, J. Alberu, N. Castelan.

5:30pm-7:30pm: Are AT1R Antibodies as Dangerous as HLA-DSAs in Renal Allografts?

E. Cuevas, J. Arreola-Guerra, E. Hernandez-Mendez, I. Salcedo, M. Vilatoba, A. Contreras, A. Sanchez-Cedillo, J. Ramirez, D. de Rungs, J. Granados, L. Morales-Buenrostro, J. Alberu.

5:30pm-7:30pm: Association of De Novo Antibody-Mediated Rejection and Increased Hospital Costs Following Kidney Transplant in Immunologically Low-Risk Patients

S. Kulkarni,¹ I. Hall.²

5:30pm-7:30pm: Bortezomib Treatment in Antibody Mediated Rejection After Kidney Transplantation

J. Lee,¹ J. Lee,¹ B. Kim,² Y. Park,³ M. Ju,¹ M. Kim,¹ S. Kim,¹ Y. Kim,¹ K. Huh.¹

5:30pm-7:30pm: Changes in Donor Specific Antibodies (DSA) First Year After Kidney Transplant (KTX): Implications for Graft Histology and Survival

F. Cosio,¹ C. Schinstock,¹ L. Cornell,³ F. de Teresa,¹ M. Stegall.²

5:30pm-7:30pm: Chronic Active Antibody Mediated Rejection (cABMR): Treatment, Outcomes and Predictors of Graft Loss in a Large Case Series

R. Redfield,¹ T. Ellis,¹ W. Zhong,¹ T. Zens,¹ M. Rizzari,¹ J. Scalea,¹ L. Jacobson,¹ D. Mandelbrot,¹ S. Parajuli,¹ B. Muth,¹ M. Mohamed,¹ S. Panzer,¹ B. Astor,¹ M. Samaniego,² D. Kaufman,¹ A. Djamali.¹

5:30pm-7:30pm: Correlation Between C3d-Binding De Novo Donor Specific HLA Antibodies and Rejection in Kidney Transplant Recipients

M. Cusick, K. Haarberg, J. Friedewald, A. Tambur.

5:30pm-7:30pm: Cyclophosphamide as a Salvage Therapy for Combined Intravenous Immunoglobulins and Plasmapheresis Refractory Antibody-Mediated Rejection

W. Habhab,¹ A. Dada,² M. Alwassia,¹ N. Baz,² N. Zabani,¹ A. Fahmy,¹ A. Abdul Malik.¹

5:30pm-7:30pm: DQB1 Epitope Matching Predicts the Development of De Novo DSA and Antibody Mediated Rejection

M. Willicombe,¹ M. Blow,² P. Brookes,² E. Santos,² D. Taube.¹

5:30pm-7:30pm: DSA Detected by ELISA-PRA Is Associated With High Risk for Development of AMR in Stable Kidney Transplant Recipients

D. Lee,¹ J. Kim,² B. Kim,³ M. Chun,⁴ I. Kim.⁵

5:30pm-7:30pm: De Novo Donor-Specific HLA Antibodies After Kidney Transplantation Are Associated With Donation After Circulatory Death and HLA-DQ Mismatch

G. Dreyer,¹ D. Roelen,² S. Brand-Schaaf,² O. Dekkers,³ M. Reinders,¹ F. Claas,² J. de Fijter.¹

5:30pm-7:30pm: Detection of Donor Specific HLA-Ab (DSA) Against Native HLA Molecules Expressed On Donor Cell Surface to Eliminate False Positive DSA in Luminex Single Antigen Beads (LMX-SAB)

G. Chen, L. Lin, D. Tyan.

5:30pm-7:30pm: Does the C1q Assay Predict the Result of Lymphocyte Flow Cross-Match (FCxM) in Potential Renal Transplant Recipients With HLA-DSA and AHG-CDC CxM negative?

J. Arreola-Guerra, A. de Santiago, A. Arvizu, N. Gonzalez-Tableros, M. Lopez, M. Vilatoba, L. Morales-Buenrostro, J. Alberu, N. Castelan.

5:30pm-7:30pm: Donor Selection and Prophylactic IVIg for Induction Immunosuppression Improves Outcomes for HIV+ Kidney Transplant Recipients (HIV+ Tx)

G. Malat,^1,2 L. Panarey,³ A. Sharma,³ K. Ranganna,³ D. Reich,² G. Xiao,² A. Doyle.³

5:30pm-7:30pm: Eculizumab in the Treatment of Early Severe Acute Antibody Mediated Rejection Following HLA-Compatible Kidney Transplantation-Case Series

M. Singh,¹ N. Macias,² V. Tatapudi,¹ B. Lee.¹

5:30pm-7:30pm: Effect of Antibody Mediated Rejection on Long-Term Renal Allograft Function

M. John, A. Smith, I. Dortonne, A. Paramesh, M. Killackey, B. Lee, R. Zhang, J. Buell.

5:30pm-7:30pm: First Clinical Data With an Improved C1q-Luminex® Assay

A. Roodenburg,² J. Bamoulid,¹ O. Staeck,¹ C. Schoenemann,² N. Lachmann,² K. Budde.¹

5:30pm-7:30pm: High Prevalence of Allograft Rejection in Kidney Recipients With a Mild Increase in Serum Creatinine: Interim Report of the ANIDAR Study

S. De Serres,¹ J. Ho,² J.-F. Cailhier,³ H. Cardinal,³ O. Désy,¹ P. Vallin,¹ S. Béland,¹ I. Côté,¹ I. Houde,¹ R. Noël,¹ I. Lapointe,¹ M. Agharazii.¹

5:30pm-7:30pm: Immune Response to Kidney and Pancreas Self-Antigens Are Associated With Antibody Mediated Rejection in Simultaneous Kidney Pancreas Transplants

M. Gunasekaran,¹ A. Siddiq,² S. Shenoy,¹ J. Wellen,¹ T. Mohanakumar.¹

5:30pm-7:30pm: Impact of HLA Antibody Monitoring After Kidney Transplantation

S. Rao,¹ M. Ghanta,¹ H. Parekh,² A. Gillespie,¹ I. Lee,¹ S. Geier,² K. Lau,³ S. Karhadkar,³ A. Di Carlo,³ S. Constantinescu.¹

5:30pm-7:30pm: Impact of Pre-Transplant Panel Reactive Antibody Levels On Renal Graft Survival in Patients With Negative Cross-Match and No Donor Specific Antibody

K. Jun,¹ M. Kim,¹ H. Kim,¹ K. Park,² S. Ahn,¹ J. Hwang,¹ S. Kim,¹ S. Park,¹ S. Kim,¹ J. Kim,¹ I. Moon.¹

5:30pm-7:30pm: Improving ABMR Diagnostics Through Advanced Anti-HLA Antibody Screening Techniques

R. Ponsirenas,^1,2 H. Cazarote,^1,2 S. Shimakura,³ J. Valdameri,¹ F. Contieri,⁴ C. von Glehn,^1,2 M. Susin.^1,2

5:30pm-7:30pm: Incidence of De Novo Donor Specific Antibodies in Kidney Transplant Recipients

C. Staino, N. Pilch, O. Moussa, K. Boyle, J. Casale, K. Covert, J. Fleming, D. Taber, H. Meadows, C. Mardis, K. Chavin, S. Nadig, J. McGillicuddy, C. Bratton, T. Srinivas, P. Baliga.

5:30pm-7:30pm: Intimal Arteritis Associated With Subsequent Graft Dysfunction in ABO-Incompatible Kidney Transplantation

D. Toki,¹ H. Iahida,¹ M. Okumi,¹ T. Shimizu,¹ M. Inui,¹ K. Omoto,¹ H. Shirakawa,¹ K. Unagami,¹ K. Honda,² J. Koike,³ K. Tanabe.¹

5:30pm-7:30pm: Isolated Microcirculation Inflammation Negatively Impacts Renal Graft Function at 5 Years

A. Chapelet,¹ M. Touzot,¹ M. Fournier,² A. Cesbron,³ K. Renaudin,⁴ A. Moreau,⁴ E. Morelon,⁵ D. Anglicheau,⁶ M. Giral.¹

5:30pm-7:30pm: Isotype Switching of Antibodies to Vimentin Following Transplantation Is Associated With Development of Transplant Glomerulopathy Following Renal Transplantation

M. Gunasekaran,¹ T. Maw,³ R. Santos,³ J. Wellen,¹ S. Shenoy,¹ T. Mohanakumar.^1,2

5:30pm-7:30pm: Kidney Transplantation (KTx) With Positive Crossmatch (XM) but No Donor Specific Antibody (DSA)

J. Verbesey, O. Timofeeva, L. Dong, B. Javaid, G. Monica, A. Gilbert, J. Moore, P. Weems, S. Ghasemian, S. Rosen-Bronson, M. Cooper.

5:30pm-7:30pm: Microcirculation Inflammation in Early Surveillance Renal Biopsy in Sensitized Patients Did Not Correlate With Graft Outcome

P. Souza,¹ D. Machado,¹ D. David,¹ G. Bezerra,¹ F. Jota de Paula,¹ H. Rodriges,² W. Nahas,¹ E. David Neto,¹ M. Castro.¹

5:30pm-7:30pm: Mycophenolic Acid Area-Under-Curve (MPA AUC) Levels Sufficient to Prevent Donor-Specific Antibody (DSA) Formation Are Not Associated With Higher Rates of CMV/EBV/BK Viral Infections

S. Narins, D. Ladie, R. Saylor, E. Richards, H. Yang, M. Waybill.

5:30pm-7:30pm: NK-Cell Subset Distribution, Renal Function and Biopsy Findings in Kidney Transplant Recipients With HLA Donor-Specific Antibodies

M. Crespo,¹ D. Redondo,¹ J. Gimeno,² J. Yelamos,³ A. Muntasell,³ A. Faura,¹ M. Pérez-Sáez,¹ M. López-Montañes,⁴ A. Torío,⁵ C. García,⁶ M. Mir,¹ J. Hernandez,⁶ M. López-Botet,^3,4 J. Pascual.¹

5:30pm-7:30pm: Novel Flow Cytometry Method for Detecting Complement-Fixing Blood Group IgG Antibody in ABO-Incompatible Renal Transplantation

T. Ishizuka,¹ M. Yasuo,¹ Y. Ishida,¹ H. Miura,¹ K. Iwadoh,² T. Murakami,² K. Kitajima,² I. Nakajima,² S. Fuchinoue.²

5:30pm-7:30pm: Number of Antigen Targets: A Key Parameter for Accurate Flow Cytometry Crossmatch Interpretation of Weak DSA

L. Hidalgo,¹ S. Hasenbank,¹ A. Halpin,¹ P. Campbell.^1,2

5:30pm-7:30pm: Outcomes Following Kidney Transplant With Low Level Positive Flow Cytometric Crossmatch

C. Schinstock, F. Cosio, M. Gandhi, L. Cornell, M. Stegall.

5:30pm-7:30pm: Outcomes of Eculizumab (ANTI-C5) Therapy for Treatment of Refractory Antiobdy-Mediated Rejection (ABMR) and Thrombotic Microangiopathy (TMA)

P. Wongsaroj,¹ J. Choi,¹ A. Vo,¹ J. Kahwaji,¹ A. Peng,¹ R. Villicana,¹ M. Haas,² S. Jordan.¹

5:30pm-7:30pm: Outcomes of Treatment of Late Antibody-Mediated Rejection in Primary Renal Transplant Recipients – A Single Center Experience

R. Prashar, A. Patel, K. Venkat.

5:30pm-7:30pm: Preformed Anti-HLA DP Donor Specific Antibodies Are Clinically Significant in Renal Transplantation

V. Dibbur, M. Willicombe, P. Brookes, R. Sergeant, A. Wardle, D. Taube.

5:30pm-7:30pm: Protocol Donor Specific Antibody Monitoring After Kidney Transplantation: What Is the Utility?

C. Staino, N. Pilch, O. Moussa, K. Boyle, J. Casale, K. Covert, J. Fleming, D. Taber, H. Meadows, C. Mardis, K. Chavin, S. Nadig, J. McGillicuddy, C. Bratton, T. Srinivas, P. Baliga.

5:30pm-7:30pm: Repeat Donor HLA Mismatch Antigens and Kidney Transplant Outcome

P. Lokhandwala,¹ M. Wang,² Z. Kadry,³ R. Shah,³ A. Jain,³ J. Gaspari,¹ N. Ghahramani,⁴ C. Abendroth,¹ H. Shike.¹

5:30pm-7:30pm: Retrospective Cohort Study Concerning Efficacy and Safety of Bortezomib in Combination With Or Without Rituximab in Antibody Mediated Rejection in Renal Transplant Recipients

M. Duerr, N. Lachmann, K. Budde, J. Waiser.

5:30pm-7:30pm: Role of CMV, BKV, and Immunosupression Non-Adherence in Early and Late De Novo Donor Specific Anti-HLA Antibody Development and Outcomes

M. Everly,¹ L. Rebellato,² K. Briley,² A. Maldonado,³ P. Bolin,² C. Haisch,² W. Kendrick,⁴ S. Kendrick,⁴ C. Morgan,² R. Harland,² P. Terasaki.¹

5:30pm-7:30pm: Serum Creatinine Is Most Predictive of Graft Loss in Late Antibody Mediated Rejection

G. Agarwal, D. Diskin, R. Reed, J. Locke, V. Kumar.

5:30pm-7:30pm: Should Current IVIg Preparations Containing High Titers of Anti-HLA-I/-II IgG be Used for Lowering the Anti-HLA IgG in Sensitized Pre-Transplant Patients and Allograft Recipients?

M. Ravindranath, P. Terasaki, C. Maehara, V. Jucaud.

5:30pm-7:30pm: The Differential Effect of HLA-DQ Mismatching on Renal Allograft Survival in Zero HLA-A,B,DR Mismatched Deceased Donor Transplants

M. Casey,¹ X. Wen,¹ S. Rehman,¹ A. Santos,¹ S. Goldstein,¹ K. Andreoni,¹ B. Kaplan,² K. Womer.¹

5:30pm-7:30pm: The Impact of Microcirculation Inflammation in Predicting Treatment Response for Late Onset Antibody Mediated Rejection

J. Lee,¹ J. Lee,¹ B. Lim,² B. Kim,³ M. Ju,¹ M. Kim,¹ S. Kim,¹ Y. Kim,¹ H. Jeong,² K. Park,⁴ K. Huh.¹

5:30pm-7:30pm: The Impact of Therapy On the Inflammatory Infiltrate in Renal Allografts With Acute and Chronic Antibody Mediated Rejection

W. Mulley,^1,2 D. Nikolic-Paterson,^1,2 A. Longano,³ Y. Han,¹ F. Ma,¹ J. Kanellis,^1,2 S. Ramessur.^1,2

5:30pm-7:30pm: Transplant Glomerulitis in Allograft Kidneys Is Correlated With Antibody-Mediated Rejection

W. Xu, T. Deng.

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