ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "CD20"

  • 2020 American Transplant Congress

    B Cell Depletion with Anti-CD20 mAb Exacerbates Anti-Donor CD4+ T Cell Responses in Highly Sensitized Transplant Model

    A. Tanaka, K. Ide, Y. Tanaka, M. Ohira, H. Tahara, H. Morimoto, H. Ohdan

    Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan

    *Purpose: Preformed donor-specific anti-human leukocyte antigen antibodies (DSAs) have been associated with detrimental effects in transplant recipients. To eliminate preformed DSAs, we desensitized DSA-positive recipients…
  • 2020 American Transplant Congress

    T and B Lymphocyte Dynamics after Genetically-Modified Pig-To-Baboon Kidney Xenotransplantation with an Anti-CD40mAb-Based Immunosuppressive Regimen

    A. Jagdale1, H. Iwase1, H. Nguyen1, T. Yamamoto1, D. Ayares2, D. Anderson1, D. Eckhoff1, D. Cooper1, H. Hara1

    1Surgery, University of Alabama at birmingham, Birmingham, AL, 2Revivicor, Blacksburg, VA, VA

    *Purpose: We have evaluated recovery of T and B lymphocytes and their subsets after depletion by anti-thymocyte globulin (ATG) and an anti-CD20mAb (Rituximab), followed by…
  • 2020 American Transplant Congress

    Rapid Preparation to Undergo ABO-Incompatible Living Donor Liver Transplantation for Acute Liver Failure

    H. Hung1, C. Lee2, Y. Wang1, J. Lee2, C. Cheng1, T. Wu1, T. Wu1, H. Chou1, K. Chan1, W. Lee2

    1Chang-gung Hospital, Taoyuan, Taiwan, 2Chang-gung Hospital, Taiyuan, Taiwan

    *Purpose: Acute liver failure is a life-threatening condition and urgent liver transplantation is needed to save lives. In the circumstance of deceased and ABO-compatible (ABO-C)…
  • 2020 American Transplant Congress

    Association between Response to Rituximab and Risk of Antibody-Mediated Rejection in ABO-Incompatible Living Kidney Transplantation

    Y. Kakuta1, M. Okumi1, T. Kanzawa1, K. Unagami2, H. Ishida2, K. Tanabe1

    1Urology, Tokyo Women's Medical University, Tokyo, Japan, 2Organ Transplant Regulation, Tokyo Women's Medical University, Tokyo, Japan

    *Purpose: Owing to limited organ availability, ABO-incompatible living kidney transplantation (ABO-ILKT) has been used extensively. Various forms of preconditioning therapies have been used alone or…
  • 2020 American Transplant Congress

    Impact of Rituximab and Apheresis Techniques in Acute Rejection Rates in ABO Incompatible Living Donor Kidney Transplant

    I. Revuelta1, E. De Sousa-Amorim1, M. Lozano2, D. Cucchiari1, J. Cid2, L. Peri3, E. Palou4, M. Musquera3, J. Martorell5, J. M. Campistol1, F. Oppenheimer1, F. Diekmann1

    1Renal Transplant Unit, Department of Nephrology and Kidney Transplant, Hospital Clinic, Barcelona, Spain, 2Apheresis and Cellular Therapy Unit, Hospital Clinic, Barcelona, Spain, 3Department of Urology, Hospital Clinic, Barcelona, Spain, 4Histocompatibility Lab. Department of Immunology, Hospital Clinic, Barcelona, Spain, 5Histocompatibility Lab, Department of Immunology, Hospital Clinic, Barcelona, Spain

    *Purpose: ABO incompatibility (ABOi) is a widespread option of living kidney donor transplantation (LKDT). However, controversies in rejection, and death-censored graft survival rates are published,…
  • 2019 American Transplant Congress

    Efficacy Of Rituximab Monotherapy On Anti-human Leukocyte Antigen Antibodies In Highly Sensitized Living Donor Kidney Transplant Patients.

    D. J. Sindi1, A. Al Jedai2, H. Aleid3, J. Brockmann4, M. Al-Awwami5, D. Alissa2, E. De Vol6, H. Al Khabbaz7, L. Fajji8

    1Clinical Pharmacy, King Faisal Specialist Hospital and Research Center (KFSH&RC), Riyadh, Saudi Arabia, 2Clinical Pharmacy, KFSH&RC, Riyadh, Saudi Arabia, 3Kidney and Pancreas transplantation, KFSH&RC, Riyadh, Saudi Arabia, 4kFSH&RC, Riyadh, Saudi Arabia, 5Clinical Director, Histocompatibility and Immunogenetics Laboratory, KFSH&RC, Riyadh, Saudi Arabia, 6KFSH&RC, Riyadh, Saudi Arabia, 7Riyadh Elm University, Riyadh, Saudi Arabia, 8Clinical Transplant Coordinator, KFSH&RC, Riyadh, Saudi Arabia

    *Purpose: We aim to examine the efficacy of Rituximab (RTX) monotherapy in reducing DSA in Highly Sensitised Living Donor Kidney Transplant (HS-LDKT) candidates and potentially…
  • 2019 American Transplant Congress

    Variable Outcomes of Recurrent Autoimmune Diabetes Post Pancreas Transplant Treated with Rituximab

    K. Venkatachalam, A. Markwardt, B. Heady, T. Alhamad, A. Malone

    Washington University, St. Louis, MO

    *Purpose: Demonstrate the outcomes of treatment with rituximab in patients with autoimmune diabetes after pancreas transplant.*Methods: We present the treatment response to rituximab in 3…
  • 2018 American Transplant Congress

    The Impact of Rituximab Dose on Hepatitis B Virus Reactivation in HBsAg-Negative/anti-HBc-Positive Kidney Transplant Recipients

    J. Lee,1 J. Park,2 Y. Jung,1 D. Kim,1 J. Lee,1 S. Song,3 J. Lee,4 J. Lee,1 B. Kim,5 M. Kim,1 S. Kim,1 Y. Kim,1 K. Huh.1

    1Surgery, Yonsei University College of Medicine, Seoul, Korea; 2Internal Medicine (Gastroenterology), Yonsei University College of Medicine, Seoul, Korea; 3Surgery, Ewha Womans University, School of Medicine, Seoul, Korea; 4Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea; 5Internal Medicine (Nephrology), Yonsei University College of Medicine, Seoul, Korea.

    Background: Hepatitis B virus (HBV) reactivation is well-recognized complication of rituximab. Although use of rituximab for sensitized patients continues to increase in kidney transplantation, the…
  • 2018 American Transplant Congress

    The Incidence of Polyomavirus-BK and Cytomegalovirus Infections in Renal Transplant Recipients Following Rituximab Administration

    A. Kraljevic, C. D'Agostino, C. Kane, K. Cunningham, A. Shetty, C. Richardson.

    Northwestern Memorial Hospital, Chicago, IL.

    Rituximab is an antibody that binds to the CD20 antigen on B cells resulting in rapid and prolonged depletion. At Northwestern Memorial Hospital, a single…
  • 2018 American Transplant Congress

    Evaluation of FlowDSA Crossmatch for Detection of Donor-Specific HLA Antibodies

    J. Lee, J. Ryu, A. Choi, E-.J. Oh.

    Laboratory Medicine, Seoul St. Mary's Hospital, the Catholic University of Korea, Seoul, Republic of Korea.

    Background: Donor-specific HLA antibodies (DSA) are detected by different crossmatch techniques. Flow cytometric crossmatching (FCXM) is sensitive method, but it is subject to false (+)…
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