ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft function"

  • 2020 American Transplant Congress

    Donor Kidney Perfusion Fluid Extracellular Vesicles as Markers of Graft Function

    A. K. Rutman, S. Negi, N. Saberi, J. Tchervenkov, S. Paraskevas

    Research Institute of the McGill University Health Institute, Montreal, QC, Canada

    *Purpose: Kidney transplantation is a life-saving treatment for many patients with end-stage renal failure. Recently, machine perfusion of kidneys prior to transplantation has emerged as…
  • 2020 American Transplant Congress

    Rabbit Anti-Thymocyte Globulin versus Anti-T Lymphocyte Globulin Rescue Therapies in Delayed Graft Function after Kidney Transplantation from Donors after Cardiac Death

    H. Yang1, Y. Shi2, X. Li1, C. Long1, H. Li3, Z. Wang3

    1Department of Organ Transplantation, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, Nanchang, China, 2Department of Pathology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 3Department of Urologic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    *Purpose: Delayed graft function (DGF) is common in recipients of kidney transplants from donation after cardiac death (DCD) donors, induction therapy with monoclonal or polyclonal…
  • 2020 American Transplant Congress

    Estrogen Receptor Beta Deletion in the Vascular Endothelium is Protective in Renal Ischemia Reperfusion Injury

    L. Krumeich1, P. Hernandez1, C. O'Brien1, S. Concors1, Z. Wang1, G. Ge1, W. Hancock2, M. Levine1

    1Hospital of University of Pennsylvania, Philadelphia, PA, 2Childrens Hospital of Philadelphia, Philadelphia, PA

    *Purpose: Renal ischemia reperfusion injury (IRI) is a major contributor to early allograft dysfunction (EAD) in kidney transplantation. We previously identified lower rates of EAD…
  • 2020 American Transplant Congress

    Pattern of Renal Allograft Injury in Recipients with Normal Donor-Derived Cell-Free DNA

    W. Xie, N. Goussous, A. Haririan, M. Weir, J. Bromberg

    University of Maryland School of Medicine, Baltimore, MD

    *Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a novel non-invasive test currently used as a biomarker for identification of transplant rejection or injury. Here, we sought…
  • 2020 American Transplant Congress

    The Impact of Deceased Donor Maintenance on the Incidence of Delayed Kidney Allograft Function

    S. Costa1, F. Barroso1, C. Oliveira1, E. Daher1, P. Fernandes1, L. Andrade2, R. Esmeraldo3, T. Sandes-Freitas1

    1Universidade Federal do Ceará, Fortaleza, Brazil, 2Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, Brazil, 3Hospital Geral de Fortaleza, Fortaleza, Brazil

    *Purpose: To evaluate the risk factors for delayed graft function (DGF) in a Brazilian cohort with high DGF incidence, focusing on variables reflecting donor maintenance.*Methods:…
  • 2020 American Transplant Congress

    Improving Evaluation and Follow-Up of Living Kidney Donors: Role of Radioisotopic Glomerular Filtration Rate and Renal Functional Reserve

    V. Cantaluppi1, G. Guglielmetti1, U. M. Morosini1, A. Nappo1, G. Merlotti1, A. Airoldi1, M. Quaglia1, C. Ronco2

    1Nephrology and Kidney Transplantation Unit, University of Piemonte Orientale (UPO), Novara, Italy, 2Nephrology, Dialysis and Kidney Transplantation Unit, University of Padova, Vicenza, Italy

    *Purpose: After donation, living kidney donors (KD) develop an early and transient loss of kidney function (KF), defined as Acute Kidney Injury (AKI). Its recovery…
  • 2020 American Transplant Congress

    Gross Morphological Score for Deceased Donor Kidneys Can Predict Delayed Graft Function in Kidney Transplant Recipients

    M. Mandurah, M. A. Levine, A. Sener, P. Luke

    Department of Kidney Transplantation, London Health Sciences Center, London, ON, Canada

    *Purpose: Both microscopy and kidney donor profile index (KDPI) scoring systems have been used to predict kidney transplant outcomes. Utilizing gross renal morphology, we designed…
  • 2020 American Transplant Congress

    LacripepTM and its Analogs Act as Novel Interventional Agents to Promote Long-Term Islet Transplantation Outcomes

    M. Ma1, K. Teixeira2, G. Laurie2, K. Brayman1, P. Chhabra1

    1Department of Surgery, University of Virginia Health System, Charlottesville, VA, 2Department of Cell Biology, University of Virginia Health System, Charlottesville, VA

    *Purpose: To study the prosecretory, prosurvival, and mitogenic effect of Lacripep™ and its analogs in enhancing islet viability, increasing insulin secretion and promoting long-term islet…
  • 2020 American Transplant Congress

    Comparative Proteomics Analysis Identifies L-FABP as a Putative Biomarker of Graft Injury During Liver Transplantation Using the ITRAQ/MRM Approach

    M. Chen, Y. Zhang, M. Han, W. Ju, Q. Zhao, Y. Chen, D. Wang, X. He

    Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

    *Purpose: In liver transplantation, much of factors have a pernicious influence on liver donor quality, such as hepatic steatosis, long term of donor hypotension, cardiac…
  • 2020 American Transplant Congress

    Development of a Split Liver Machine Perfusion Protocol to Provide Comparative Controls in Assessing Therapeutic Interventions

    J. A. Attard1, L. Wallace1, Y. Boteon1, V. Ronca1, D. Osei-Bordom1, Y. Oo1, H. Mergental2, D. Mirza2, S. Afford1

    1Centre for Liver and Gastroenterology Research, University of Birmingham, Birmingham, United Kingdom, 2Liver Surgery Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom

    *Purpose: Ex situ donor liver machine perfusion is developing into a promising tool to test organ viability prior to transplantation and vehicle to assess novel…
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