IL-33 Enhances Host Tolerance to Candida albicans Kidney Infections Through Induction of IL-13 Production by CD4+ T Cells
1Surgery, Ulsan University Hospital, Ulsan, Korea
2Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea
3Internal Medicine, Ulsan University Hospital, Ulsan, Korea
4School of Biological Sciences, University of Ulsan, Ulsan, Korea.
Meeting: 2015 American Transplant Congress
Abstract number: A260
Keywords: Fungal infection, T cell activation, Tolerance
Session Information
Session Name: Poster Session A: Preclinical Immunosuppression and Tolerance
Session Type: Poster Session
Date: Saturday, May 2, 2015
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Exhibit Hall E
Susceptibility to systemic Candida albicans infection is determined not only by immune resistance but also by the ability to control Candida-induced immunopathologies. We previously showed that exogenous IL-33 can increase resistance to peritoneal C. albicans infection by regulating multiple steps of the neutrophil anti-Candida response. Here, using a mouse model of systemic candidiasis, we observed that IL-33 administration limited fungal burden and inflammation and increased survival. In kidneys, IL-33 seemed to directly act on neutrophils and CD4+ T cells: IL-33 administration enhanced fungal clearance by increasing neutrophil phagocytic activity without which Candida proliferation was uncontrollable. On the other hand, IL-33 stimulated CD4+ T cells to produce IL-13, and it in turn drove the polarization of macrophages toward the M2 type. Furthermore, the absence of IL-13 abolished IL-33-mediated polarization of M2 macrophages and renal functional recovery. In addition, IL-33 and IL-13 acted synergistically to increase M2 macrophage polarization and its phagocytic activity. Overall, this study identifies IL-33 as a cytokine that is able to induce resistance and tolerance, and suggests that targeting resistance and tolerance simultaneously with therapeutic IL-33 may benefit patients with systemic candidiasis.
To cite this abstract in AMA style:
Cho H, Lee J, Tran V, Kim H, Kim J, Kwon B. IL-33 Enhances Host Tolerance to Candida albicans Kidney Infections Through Induction of IL-13 Production by CD4+ T Cells [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/il-33-enhances-host-tolerance-to-candida-albicans-kidney-infections-through-induction-of-il-13-production-by-cd4-t-cells/. Accessed October 3, 2024.« Back to 2015 American Transplant Congress