2015 American Transplant Congress » Poster Session A: Preclinical Immunosuppression and Tolerance

5:30pm-7:30pm

A Novel Post-Transplant High-Dose Cyclophosphamide-Based Regimen to Promote Immune Tolerance After VCA

G. Furtmüller,¹ M. Fryer,¹ B. Oh,¹ S. Ganguly,² J. Izzi,³ D. Cooney,¹ G. Raimondi,¹ W. Lee,¹ L. Luznik,² G. Brandacher.¹

5:30pm-7:30pm

Aging Enhances Immunosuppressives Capacities of Tacrolimus By Functional Changes of CD4+ T-Cells

F. Krenzien,¹ M. Quante,¹ A. ElKhal,¹ H. Uehara,¹ R. Abdi,² B. Slegtenhorst,¹ H. Biefer,¹ S. Tullius.¹

5:30pm-7:30pm

Altered Intestinal Microbiome as a Potential Biomarker for Failed Immune-Regulation in Autoimmune Type 1 Diabetes Mellitus

P. Chhabra,¹ A. Spano,² D. Bowers,¹ M. Wu,² L. Langman,¹ M. Timko,² K. Brayman.¹

5:30pm-7:30pm

Anti-CD122 + Costimulation Blockade Prolongs Allograft Survival

D. Mathews,¹ L. Higginbotham,¹ Y. Dong,¹ C. Breeden,¹ C. Larsen,¹ J. Tso,² A. Adams.¹

5:30pm-7:30pm

Cell Type of the Tolerizing Inoculum Plays a Role in the Formation of of Molecular Chimerism in Murine Neonatal Tolerance

X. Wang,¹ H. Mewhort,¹ S. Wang,¹ S. Tollenaar,¹ K. Tao,¹ L. West.^1,2,3

5:30pm-7:30pm

Combined Bone Marrow Plus Liver Transplantation in Cynomolgus Monkeys

J. Weiner, Y. Kato, R. Duran-Struuck, M. Martinez, S. Baker, P. Alonso, J. Zitsman, A. Wu, P. Houck, T. Pinyavat, J. Lefkowitch, S. Chaudhry, T. Kato, M. Sykes, A. Griesemer.

5:30pm-7:30pm

DNA Methytransferase 1 Inhibition Potently Suppresses T Cell Cycle Progression Through Demethylation of the Key Cell Cycle Inhibitors p15, p16, p21 and p27

T. Ma, Y. Pei, R. Tao.

5:30pm-7:30pm

Differential Expression and Function of ASC and Nlrp3 Inflammasome Adaptors in Hematopoietic Stem Cells (HSCs)

A. Scheinok, R. Elahimehr, A. Shigeoka, S. Kasimsetty, D. McKay.

5:30pm-7:30pm

Donor Specific Tolerance Can Be Induced by Donor Bone Marrow Transfer With Activation of Invariant Naturel Killer T Cells

S. Miyairi,¹ T. Hirai,¹ R. Shibahara,¹ K. Omoto,¹ S. Nunoda,² K. Yamazaki,² Y. Ishii,³ K. Tanabe.¹

5:30pm-7:30pm

Dual PI3K-mTOR Inhibition on Human T Cell Activation, Proliferation, and Differentiation: The First Step in the Development of New Immunosuppressants

V. Vilchez,¹ A. Castellanos,¹ D. Butterfield,³ M. Mitov,³ C. Hoopes,¹ F. Marti,² R. Gedaly.¹

5:30pm-7:30pm

ECDI Fixed Donor Splenocytes Combined With α-1 Antitrypsin Induce Immune Tolerance in Mice Cardiac Transplantation Model

G. Chen,¹ X. Lai,¹ J. Qiu,¹ L. Qiu,² X. Mai,² L. Chen.¹

5:30pm-7:30pm

Effects of Heart and Lung Co-Transplantation Across a Full MHC Barrier in Miniature Swine

M. Madariaga, P. Spencer, S. Michel, G. La Muraglia II, M. O'Neil, E. Mannon, C. Leblang, I. Rosales, R. Colvin, D. Sachs, J. Allan, J. Madsen.

5:30pm-7:30pm

Effects of Mast Cell Stabilization on the Development of Aspiration-Induced Fibrosis in a Rat Model

E. Sapmaz, Z. Sun, J.-C. Chang, N. Sanders, S. Bell, M. Everett, Z. Holzknecht, W. Parker, R. Davis, S. Lin.

5:30pm-7:30pm

Emerging Application of Active Immune Targeted Delivery in Transplantation

M. Uehara,¹ A. Jamil,¹ M. McGrath,¹ Z. Solhjou,¹ N. Banouni,¹ S. Tullius,² C. Jianjun,³ R. Abdi.¹

5:30pm-7:30pm

Feasibility of Regulatory T Cell Cryopreservation and Banking for Clinical Therapeutic Applications

K. Gołąb,¹ O. Savari,¹ S. Ramachandran,¹ Z. Tekin,¹ M. Tibudan,¹ J. Millis,¹ P. Trzonkowski,² P. Witkowski.¹

5:30pm-7:30pm

Glycogen Synthase Kinase 3β Inhibition Promotes Human iTreg Differentiation and Suppressive Function

Y. Xia, H. Zhuo, Y. Lu, L. Deng, R. Jiang, L. Zhang, L. Pu, X. Wang.

5:30pm-7:30pm

HO-1 Modified Macrophages Promote Autophagy by Activating Sirt1/TGF-β/Smad4 Signaling in Ischemia-Stressed Mouse Liver Transplants

S. Yue, J. Huang, K. Nakamura, M. Zhou, X.-D. Shen, R. Busuttil, B. Ke, J. Kupiec-Weglinski.

5:30pm-7:30pm

Heart En Bloc Thymus Transplantation Permits Long-Term, Acute Rejection-Free Cardiac Allograft Survival in Nonhuman Primates (NHPs)

M. Tonsho,¹ P. Spencer,¹ T. Millington,¹ A. Muniappan,¹ A. Tena,² R. Smith,³ R. Colvin,³ J. Allan,^1,2 J. Madsen.^1,2,4

5:30pm-7:30pm

Human Adipose Derived Mesenchymal Stem Cells Enhance Bone Marrow Engraftment and Induce Immunological Tolerance

R. Saidi,² B. Rajeshkumar,¹ P. Agrawal,¹ M. Rashighi.¹

5:30pm-7:30pm

Human CD8⁺TCR^– Facilitating Cells Enhance HSC Engraftment In Vivo and Promote HSC Survival In Vitro

Y. Huang,¹ M. Elliott,¹ E. Yolcu,¹ T. Miller,¹ L. Bozulic,² Y. Wen,¹ H. Xu,¹ S. Ildstad.^1,2

5:30pm-7:30pm

IL-33 Enhances Host Tolerance to Candida albicans Kidney Infections Through Induction of IL-13 Production by CD4⁺ T Cells

H. Cho,^1,2 J. Lee,^2,3 V. Tran,⁴ H. Kim,^2,4 J. Kim,^2,4 B. Kwon.^2,4

5:30pm-7:30pm

Immunomodulation of Human T Cells by a Novel RALG Preparation With Higher Specificity Toward Activating T Cells

K. Samy, H. Xu, A. Kirk.

5:30pm-7:30pm

Impact of HMOX1 Genetic Variation in Pancreas Transplant Recipients On Long-Term Graft Outcome

C. Duff,¹ A. Hamilton,¹ S. Mittal,^2,3,4 M. Barnardo,^2,3 S. Fuggle,^2,3 P. Friend,^2,3 S. Gough,^1,4 M. Simmonds.¹

5:30pm-7:30pm

Induction of HO-1 High Expression Enhances the Capacity of Immature Dendritic Cells to Modulate Alloimmune Responses

G. Chen, Y. Zhao, L. Wang, S. Chen, X. Huang.

5:30pm-7:30pm

Neonatal Tolerance: Donor and Host Cells Fuse in Livers of Newborn Mice Injected With F1-Bone Marrow/Spleen Cells

R. Bascom, K. Tao, S. Tollenaar, L. West.

5:30pm-7:30pm

Non-Cytoreductive Immunosuppression Prevents Rejection of Vascularized Composite Allografts

B. Oh, G. Furtmüller, M. Fryer, G. Raimondi, D. Cooney, W. Lee, G. Brandacher.

5:30pm-7:30pm

PI3Kα and STAT1 Interplay Regulates Human Mesenchymal Stem Cell Immune Polarization

E. Kefalogianni,¹ M. Mounayar,² B. Smith,² J. Azzi,² L. Chabtini,² P. Fiorina,² M. Kraus,³ R. Briddell,⁴ W. Fodor,⁵ A. Herrlich,¹ R. Abdi.²

5:30pm-7:30pm

Primary and Secondary Vaccine Responses in a Non-Human Primate Model of Cardiac Allotransplantation

S. Dahi,¹ E. Kang,¹ T. Zhang,¹ B. Vanhove,² A. Azimzadeh,¹ R. Pierson III.¹

5:30pm-7:30pm

Relative In Vitro Immunoregulatory Effects of Everolimus, Sirolimus, Tacrolimus, Mycophenolic Acid and Drug Combinations

J. Mathew, X. Huang, J. Leventhal, L. Gallon, J. Miller, J. Levitsky.

5:30pm-7:30pm

Single Infusion of Donor-Type Splenocytes Treated With Extracorporeal Photopheresis Prior to Transplantation Significantly Prolongs Cardiac Allograft Survival in Mice

J. Schneiderman,¹ J. Ye,² X. Yeap,² M. Caralt,² J.-J. Wang,² Z. Zhang.²

5:30pm-7:30pm

Targeted Rapamycin Nanotherapy Dampens Memory T Cell Function

S. Nadig,¹ S. Esckilsen,¹ A.-M. Broome,² S. Dixit,² C. Atkinson.³

5:30pm-7:30pm

Thymic Transplantation to Determine Mechanisms of Thymic Involution: Insulin-Like Growth Factor 1 Receptor and Forkhead Box Protein N1 in the Thymus Play a Role in Maintaining the Juvenile Thymus

K. Yamada, M. Tasaki, M. Sekijima, A. Kawai, V. Villani, T. Tanabe, I. Hanekamp, A. Shimizu, D. Sachs.

5:30pm-7:30pm

microRNA-494 Promotes Cyclosporine-Induced Nephrotoxicity and Epithelial to Mesenchymal Transition By Inhibiting PTEN

J. Yuan,¹ C. Benway,^1,2 J. Bagley,¹ J. Iacomini.^1,2