ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Tolerance"

  • 2020 American Transplant Congress

    Fate of Donor-Derived Regulatory Dendritic Cells (DCreg) and Augmentation of Host Regulatory T Cells Following Their Infusion Into Prospective Living-Donor Liver Transplant Recipients

    A. W. Thomson, C. Macedo, A. F. Zahorchak, X. Gu, A. Humar, F. G. Lakkis, M. A. Styn, D. M. Metes

    Starzl Transplantation Institute, Pittsburgh, PA

    *Purpose: Our purpose was to ascertain the fate of ex vivo-generated donor-derived DCreg and their influence on host T cells prior to transplant in a…
  • 2020 American Transplant Congress

    Allograft Parenchymal Cell Expression of Tlr9 is Required for Endogenous Donor-Reactive Memory Cd8 T Cell Activation within High-Risk Cardiac Allografts to Mediate Ctla-4 Ig Resistant Graft Rejection

    D. Ueda, H. Tsuda, S. Miyairi, R. L. Fairchild

    Lerner Reserch Institute, Cleveland Clinic, Cleveland, OH

    *Purpose: Increased ischemia-reperfusion graft inflammation provokes activation of endogenous donor-reactive memory CD8 T cells within complete MHC-mismatched cardiac allografts at 24 hrs after graft reperfusion…
  • 2020 American Transplant Congress

    Intra-Lymph Node Injection of Rapamycin-Alloantigen Microparticles Regulates Dendritic Cell Antigen Presentation

    C. M. Paluskievicz1, Y. Xiong1, W. Piao1, M. Willson-Shirkey1, H. Eppler2, C. M. Jewell2, J. S. Bromberg1

    1U Maryland, Baltimore, MD, 2U Maryland, College Park, MD

    *Purpose: Microparticles (MPs) carrying peptide antigen with immune signals can be directly delivered to lymph nodes (LNs) via intra-LN injections to shape both pro-inflammatory or…
  • 2020 American Transplant Congress

    Electroacupuncture Promotes Induction of Long-Term Allograft Survival by Enhancing Lymphatic Migration of CD4+Foxp3+ Tregs via Upregulating Their LTalpha1beta2 Expression

    H. Liu, Y. Chen, F. Qiu, Z. Dai

    Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China

    *Purpose: Induction of long-term transplant survival without continuous global immunosuppression is a highly desired goal in transplantation. Electroacupuncture (EA) has been shown to regulate immunity…
  • 2020 American Transplant Congress

    Operational Tolerance in Kidney Transplant Recipients: Tomogram Transcriptomic Study

    O. Viklicky1, J. Klema2, P. Mrazova1, D. Abramowitz3, M. Abramowicz4, A. Massart3, P. Hruba1

    1Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2Czech Technical University, Prague, Czech Republic, 3Antwerp University Hospital, Antwerp, Belgium, 4Université Libre de Bruxelles, Brussels, Belgium

    *Purpose: TOMOGRAM is a European multicenter study, that aims to identify transcriptomic and genomic signatures of operational tolerance (OT) in a recently identified cohort of…
  • 2020 American Transplant Congress

    Torc1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B

    J. B. Alhaddad, H. Allos, B. S. Al Dulaijan,, S. K. Eskandari, I. Sulkaj, G. Melhem, J. Y. Choi, J. R. Azzi

    Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    *Purpose: The use of Regulatory T cells (Tregs) in adoptive cell therapy has been hindered by their short survival following their adoptive transfer. We have…
  • 2020 American Transplant Congress

    Myeloid Derived Suppressor Cells Expanded by Granulocyte-Colony Stimulating Factor Prolong Allogeneic Cardiac Graft Survival When Compared with MDSCs Expanded by Different Means

    Y. S. Lee, T. Zhang, J. S. Bromberg, J. R. Scalea

    Department of Surgery, University of Maryland, Baltimore, MD

    *Purpose: Myeloid-derived suppressor cells (MDSCs) inhibit T cell responses and may provide a pathway towards tolerance. Granulocyte-colony stimulating factor (GCSF) is used in clinical practice…
  • 2020 American Transplant Congress

    Agonistic Anti-CD272 Antibody (6B2) Suppressed Donor Specific Antibody Through Inducible Regulatory T Cells

    Y. Yamamoto1, M. Uchiyama2, K. Uchida3, H. Yagita4, M. Niimi1

    1Surgery, Teikyo University, Tokyo, Japan, 2Cardiovascular Surgery, Teikyo University, Tokyo, Japan, 3Hepato- Biliary- Pancreatic Surgery, Juntendo University, Tokyo, Japan, 4Immunology, Juntendo University, Tokyo, Japan

    *Purpose: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) is a coinhibitory molecule and may play an important role in alloimmune responses. We…
  • 2020 American Transplant Congress

    A Proof-of-Principle Study to Evaluate Autologous Hematopoietic Stem Cell Transplantation for Allogeneic Organ Transplant Tolerance (ASCOTT)

    A. Chruscinski1, S. Juvet1, S. Moshkelgosha1, E. Renner1, L. Lilly1, N. Selzner1, C. Bredeson2, O. Adeyi1, S. Fischer1, A. Demetris3, J. Zhang1, M. Epstein1, A. Clement2, K. Khalili1, Z. Galvin1, A. Humar1, T. Kim1, K. Tinckham1, T. Yi1, G. Levy1, H. Atkins2

    1Multi-Organ Transplantation, University Health Network, Toronto, ON, Canada, 2The Ottawa Hospital, Ottawa, ON, Canada, 3University of Pittsburgh, Pittsburgh, PA

    *Purpose: Long-term survival of recipients of solid organ transplants is limited by chronic rejection, disease recurrence and immunosuppression-induced toxicity. Self-tolerance is established after autologous hematopoietic…
  • 2020 American Transplant Congress

    Thalidomide and Dexamethasone Combinatorial Treatment Induces Tolerogenic Signals by Systemic Immunomodulation of T Cells and Dendritic Cells

    B. Kim1, E. Kim2, J. Kim2, H. Choi3, H. Lee2, J. Lee4, M. Kim4, Y. Kim4, K. Huh4

    1Department of Internal Medicine, Yonsei University Health System, Seoul, Korea, Republic of, 2The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea, Republic of, 3Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of, 4Department of Transplantation Surgery, Yonsei University Health System, Seoul, Korea, Republic of

    *Purpose: Preventing or reducing allograft rejection is critical in organ transplantation, and the need for immune modulation rather than immune suppression has been emphasized. Many…
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