2022 American Transplant Congress
Long-Term Insulin Independence Achieved by a Multimodal Approach to Beta-Cell Replacement in Patients with Type I Diabetes
*Purpose: Long-term insulin independence in beta-cell replacement, via islet or pancreas transplant, remains limited by the toxic effects of calcineurin inhibitors (CNI) on beta cells…2022 American Transplant Congress
Urinary Metabolomic Profiling from Spontaneous Tolerant Kidney Transplanted Recipients Shows Enrichment in Tryptophan-Derived Metabolites
*Purpose: Operational tolerance is the holy grail in solid organ transplantation. Previous reports showed that the urinary compartment of operationally tolerant recipients harbored a specific…2022 American Transplant Congress
Apheresis of Deceased Donors: A New Source of Mobilized Peripheral Blood Hematopoietic Stem Cells for Transplant Tolerance
*Purpose: Solid organ transplantation is the therapy of choice for many patients with end-stage organ failure, but recipients must remain on lifelong immune suppression, leaving…2022 American Transplant Congress
Regulatory Gene Pathways Are Upregulated in Heart Transplant Biopsies with Quilty Lesions
Pathology, UTSW Medical Ctr, Dallas, TX
*Purpose: Quilty lesions (QL) are commonly sub-endocardial lymphoid aggregates found in biopsies from heart transplants. Their appearance and presence in the cardiac tissue is still…2022 American Transplant Congress
Infiltrating CD8+ Cytotoxic T Cells Are Converted to a Regulatory Phenotype in Accepted Kidney Allografts
*Purpose: Mouse kidney allografts are spontaneously accepted in select, fully-mismatched donor-recipient strain combinations (i.e. DBA/2J to C57BL/6 (B6)) without any immunosuppressive drug treatment. We have…2022 American Transplant Congress
Effect of CD8+ Cell Depletion in Treg Mediated Skin Graft Survival
*Purpose: The selective in vivo expansion and activation of regulatory T cells via administration of interleukin-2 (IL-2) coupled to a specific antibody against IL-2 (IL-2…2022 American Transplant Congress
Trajectory Analysis Of Single Cell RNAseq Data Suggest Intrarenal Induction Of Tregs In Spontaneously Accepted Kidney Allografts
*Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) are spontaneously accepted independent of the recipient’s thymus, spleen, and lymph nodes.…2022 American Transplant Congress
A FRET-Based Technique to Quantify Foxp3 Acetylation in TREG
*Purpose: Foxp3 acetylation is essential to TREG stability and function. Acetylation protects Foxp3 from degradation, and acetylated Foxp3 translocates to the nucleus to activate the…2022 American Transplant Congress
Regulatory T Cell PopulationsMay be Associated with Transplant Outcomes
*Purpose: The development of immunosuppressants has enabled remarkable progress in kidney transplantation (KT). However, current immunosuppressants cannot achieve induction of immune tolerance and their nonspecific…2022 American Transplant Congress
Donor-Specific T Cell Senescence In Operationally Tolerant Liver Transplant Recipients
*Purpose: Recent evidence indicates a correlation in liver transplant recipients between successful operational tolerance (OT) post immunosuppression withdrawal (ISW) with both recipient age and time…
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