Articles tagged "Tolerance"

2021 American Transplant Congress
Effects of IL-2 and/ or Anti-IL6R Therapy on Long-term Cardiac Allograft Survival in Non-Human Primates (NHPs)
C. L. Miller, K. J. Ahrens, J. M. O, P. M. Patel, J. A. Morrissette, D. Becerra, T. Costa, A. Dehnadi, I. M. Hanekamp, G. Benichou, J. C. Madsen
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Cardiac allograft tolerance in NHPs has been achieved by our group using a mixed chimerism model with allogeneic bone marrow transplant after non-myeloablative conditioning…
2021 American Transplant Congress
Laminin Alpha 4 and Alpha5 Differentially Regulate Lymph Node Tolerogenic Structure
L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena¹, T. Zhang¹, J. Iyyathurai², R. Lakhan¹, R. Abdi³, J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²CVID, UMB, Baltimore, MD, ³Harvard University, Boston, MD
*Purpose: Lymph node (LN) stromal laminins α4 (Lama4) and α5 (Lama5) are associated with tolerance and immunity, respectively. We hypothesized that stromal Lama4 and Lama5…
2021 American Transplant Congress
Selective Bcl-2 Inhibition to Deplete Hematopoietic Stem Cells in Bone Marrow Niche: A Novel Approach to Promote Mixed Chimerism
T. Hirose¹, H. Sasaki¹, G. Lassiter¹, D. Ma¹, T. Oura¹, A. Dehnadi¹, A. Cosimi¹, P. Cippa², T. Fehr², T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Institute of Physiology, University of Zurich, Zurich, Switzerland
*Purpose: A recent murine study has shown that successful mixed chimerism is achievable without myelosuppressive treatments by Bcl-2 inhibition. However, the mechanism by which selective…
2021 American Transplant Congress
Clinical Value of Surveillance Biopsies in Pediatric Liver Transplantation: A Single Center Experience with >800 Biopsies
B. Rocque¹, A. Zaldana¹, C. Weaver², J. Huang¹, A. Barbetta¹, V. Shakhin², C. Goldbeck¹, G. Yanni², R. Kohli², Y. Genyk¹, J. Emamaullee¹
¹Surgery, University of Southern California Keck School of Medicine, Los Angeles, CA, ²Pediatrics, Children’s Hospital-Los Angeles, Los Angeles, CA
*Purpose: While pediatric liver transplantation (LT) results in excellent long-term outcomes, a high incidence of early acute cellular rejection (ACR) and late graft fibrosis persists.…
2021 American Transplant Congress
Selective Bcl-2 Inhibition for Induction of Mixed Chimerism and Renal Allograft Tolerance without Myelosupression
G. Lassiter¹, T. Hirose¹, H. Sasaki¹, D. Ma¹, T. Oura¹, A. Dehnadi¹, A. Cosimi¹, P. Cippa², T. Fehr³, T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Division of Nephrology, Ente Ospedaliero Cantonale, Lugano, Switzerland, ³Division of Nephrology, University of Zurich, Zurich, Switzerland
*Purpose: Immunologic tolerance of renal allograft has been achieved by induction of hematopoietic chimerism through donor bone marrow transplantation (DBMT). The myeloablative and genetic toxicity…
2021 American Transplant Congress
Increased T Cell Cross-dressing in Accepted Kidney Allografts
Q. Yuan¹, S. Hong², E. Szuter², I. Rosales², Y. Zhao², B. Gonzalez-Nolasco², G. Benichou², P. Russell², J. Madsen², R. Colvin², A. Alessandrini²
¹Massachusetts General Hospital/Chinese PLA General Hospital, Boston, MA, ²Massachusetts General Hospital, Boston, MA
*Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) develop tolerance while other combinations do not (e.g. B6 to DBA/2). We…
2021 American Transplant Congress
Tissue-Specific Features of Immunity Revealed by Single-cell RNA Sequencing of Healthy Human Kidney
S. Q. Crome¹, J. M. Szusz², C. McEvoy¹, J. An¹, S. Clotet-Freixas¹, S. A. MacParland¹, G. D. Bader³, A. Konvalinka¹
¹Toronto General Hospital Research Institute, Ajmera Transplant Centre, University Health Network and the University of Toronto, Toronto, ON, Canada, ²Immunology, University of Toronto, Toronto, ON, Canada, ³Molecular Genetics, University of Toronto, Toronto, ON, Canada
*Purpose: Tissue-resident immune cells reside within distinct niches across organs, where they sustain tissue homeostasis and rapidly respond to perturbations in the local microenvironment. Across…
2021 American Transplant Congress
Successful Induction of Hematopoietic Chimerism by Dual Inhibition of Mcl-1 and Bcl-2 Without Myeloablative Treatments in Nonhuman Primates
T. Hirose, D. Ma, G. Lassiter, T. Kawai
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Induction of hematopoietic chimerism by donor bone marrow transplantation (BMT) is essential for achievement of allograft tolerance in clinical HLA mismatched kidney transplantation, while…
2021 American Transplant Congress
Estrogen Receptors Alpha and Beta are Required for Immune Homeostasis and Normal Treg Function
L. M. Christensen¹, T. Akimova², G. Ge³, R. Han¹, L. Wang¹, P. Hernandez³, C. O'Brien³, M. H. Levine³, W. W. Hancock¹
¹Children's Hospital of Philadelphia, Philadelphia, PA, ²Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, ³University of Pennsylvania, Philadelphia, PA
*Purpose: Estrogen signaling is a critical component of mammalian homeostasis, acting through a complex and interconnected system of hormone synthesis pathways and receptor signaling cascades.…
2021 American Transplant Congress
TOLS are Novel Regulatory TLOs with A B Cell Signature
I. Rosales¹, Q. Yuan¹, C. Yang¹, P. Russell¹, J. Madsen¹, A. Alessandrini¹, R. Colvin¹, -. AA and RC²
¹Massachusetts General Hospital, Boston, MA, ²Co-Senior Authors, Boston, MA
*Purpose: Our previous studies suggest that a DBA/2 kidney graft is accepted by a MHC-fully mis-matched C57/BL6 recipient. Accepted renal allografts exhibited lymphoid like structures…

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