2020 American Transplant Congress
Fate of Donor-Derived Regulatory Dendritic Cells (DCreg) and Augmentation of Host Regulatory T Cells Following Their Infusion Into Prospective Living-Donor Liver Transplant Recipients
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Our purpose was to ascertain the fate of ex vivo-generated donor-derived DCreg and their influence on host T cells prior to transplant in a…2020 American Transplant Congress
Allograft Parenchymal Cell Expression of Tlr9 is Required for Endogenous Donor-Reactive Memory Cd8 T Cell Activation within High-Risk Cardiac Allografts to Mediate Ctla-4 Ig Resistant Graft Rejection
Lerner Reserch Institute, Cleveland Clinic, Cleveland, OH
*Purpose: Increased ischemia-reperfusion graft inflammation provokes activation of endogenous donor-reactive memory CD8 T cells within complete MHC-mismatched cardiac allografts at 24 hrs after graft reperfusion…2020 American Transplant Congress
Intra-Lymph Node Injection of Rapamycin-Alloantigen Microparticles Regulates Dendritic Cell Antigen Presentation
1U Maryland, Baltimore, MD, 2U Maryland, College Park, MD
*Purpose: Microparticles (MPs) carrying peptide antigen with immune signals can be directly delivered to lymph nodes (LNs) via intra-LN injections to shape both pro-inflammatory or…2020 American Transplant Congress
Electroacupuncture Promotes Induction of Long-Term Allograft Survival by Enhancing Lymphatic Migration of CD4+Foxp3+ Tregs via Upregulating Their LTalpha1beta2 Expression
Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
*Purpose: Induction of long-term transplant survival without continuous global immunosuppression is a highly desired goal in transplantation. Electroacupuncture (EA) has been shown to regulate immunity…2020 American Transplant Congress
Operational Tolerance in Kidney Transplant Recipients: Tomogram Transcriptomic Study
*Purpose: TOMOGRAM is a European multicenter study, that aims to identify transcriptomic and genomic signatures of operational tolerance (OT) in a recently identified cohort of…2020 American Transplant Congress
Torc1 Inhibition Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: The use of Regulatory T cells (Tregs) in adoptive cell therapy has been hindered by their short survival following their adoptive transfer. We have…2020 American Transplant Congress
Myeloid Derived Suppressor Cells Expanded by Granulocyte-Colony Stimulating Factor Prolong Allogeneic Cardiac Graft Survival When Compared with MDSCs Expanded by Different Means
Department of Surgery, University of Maryland, Baltimore, MD
*Purpose: Myeloid-derived suppressor cells (MDSCs) inhibit T cell responses and may provide a pathway towards tolerance. Granulocyte-colony stimulating factor (GCSF) is used in clinical practice…2020 American Transplant Congress
Agonistic Anti-CD272 Antibody (6B2) Suppressed Donor Specific Antibody Through Inducible Regulatory T Cells
*Purpose: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) is a coinhibitory molecule and may play an important role in alloimmune responses. We…2020 American Transplant Congress
A Proof-of-Principle Study to Evaluate Autologous Hematopoietic Stem Cell Transplantation for Allogeneic Organ Transplant Tolerance (ASCOTT)
*Purpose: Long-term survival of recipients of solid organ transplants is limited by chronic rejection, disease recurrence and immunosuppression-induced toxicity. Self-tolerance is established after autologous hematopoietic…2020 American Transplant Congress
Thalidomide and Dexamethasone Combinatorial Treatment Induces Tolerogenic Signals by Systemic Immunomodulation of T Cells and Dendritic Cells
*Purpose: Preventing or reducing allograft rejection is critical in organ transplantation, and the need for immune modulation rather than immune suppression has been emphasized. Many…
American Transplant Congress abstracts