2019 American Transplant Congress
Use of Low Dose Interleukin-2 to Expand Regulatory T-cells and Facilitate the Complete Discontinuation of Immunosuppression in Human Liver Transplantation
*Purpose: Low dose interleukin-2 (LDIL-2) is capable of expanding endogenous CD4+CD25+FoxP3+ regulatory T-cells (Tregs) in vivo but its role in human solid organ transplantation is…2019 American Transplant Congress
Treg And Bone Marrow Infusion Promotes Survival Of Donor Kidney Grafted Months After Disappearance Of Mixed Chimerism
Columbia Center for Translational Immunology, Columbia University, New York City, NY
*Purpose: Transient mixed chimerism induced with non-myeloablative conditioning in monkeys and humans induces tolerance to about 70% of donor kidney grafts transplanted at the time…2019 American Transplant Congress
AMD3100 (Plerixafor) as a Single-Dose Stem Cell Mobilizing Agent in Vascularized Composite Tissue Allograft (VCA) Transplantation in a Canine DLA-Mismatch Model
*Purpose: Vascularized Composite Allograft (VCA) transplantation is a clinical reality but limited by toxicities of chronic immunosuppression and rejection. Current clinical tolerance protocols rely on…2019 American Transplant Congress
Mismatched Antibody Epitopes and the Development of HLA-DQ De Novo DSA during Immunosuppression Withdrawal in Liver Transplant Recipients
*Purpose: We recently described, in liver transplant (LT) recipients from the ITN030ST study, the development of de novo donor-specific HLA antibodies (dnDSA) and their impact…2019 American Transplant Congress
Superiority of Donor-Specifically vs. Polyclonally Expanded Regulatory T Cells in Controlling Graft Rejection in the NSG Mouse Human Skin Graft Model
*Purpose: Naturally occurring CD4+CD25highFOXP3+ Regulatory T cells (Tregs) function as mediators of immune homeostasis. So, they are beginning to be utilized for controlling hyper-immunity and…2019 American Transplant Congress
Tolerance Induction with Hematopoietic Stem Cells in Kidney Transplantations
Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Tolerance induction is considered to be the final goal in the field of organ transplantation. We have performed combined bone marrow and kidney transplantation…2019 American Transplant Congress
Murine Cmv Infection Impairs Transplantation Tolerance: A Critical Role Of Intragraft Anergic Cd4 T Cells
1Medicine, Duke University, Durham, NC, 2Pathology, Northwestern University, Chicago, IL
*Purpose: It is well known that certain infections can impair the stability of transplantation tolerance in recipients who had prolonged functional grafts, resulting in graft-loss.…2019 American Transplant Congress
Treg-Lymphatic Crosstalk: Lymphotoxin Signals as Modulators of Immunity and Suppression
*Purpose: Little is known about the molecular cues that regulate the entry of leukocytes across lymphatic vessels. Regulatory T cells (Treg) express high amounts of…2019 American Transplant Congress
Costimulatory Blockade and Allo-Specific Treg Therapy for Liver Transplant Recipients: Preclinical Data
*Purpose: Adoptive transfer of ex vivo generated donor-specific regulatory T cells (Treg) by using CD28/B7 costimulatory blockade (CSB) to induce transplant (TX) tolerance and minimize…2019 American Transplant Congress
Dichotomous Role Of Donor T Cells In The Efficacy Of Tolerogenic Therapies For Transplant Rejection
Plastic Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: Costimulation blockade-based regimens are a promising strategy to promote transplant tolerance. However, their efficacy is affected by multiple factors, many of which remain unknown.…
American Transplant Congress abstracts