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Eosinophils Attenuate Hepatic Ischemia Reperfusion Injury in Mice Through St2-Dependent Il-13 Production

Y. Yang, Y. Wang, M. Wang, J. Jeong, L. Xu, Y. Wen, C. Emontzpohl, W. Dar, C. Ju

Department of Anesthesiology, McGovern Medical School University of Texas Health Science Center at Houston, Houston, TX

Meeting: 2021 American Transplant Congress

Abstract number: 351

Keywords: Bone marrow transplantation, Eosinophils, Ischemia, Liver

Topic: Basic Science » Ischemia Reperfusion & Organ Rehabilitation

Session Information

Session Name: Ischemia Reperfusion & Organ Rehabilitation

Session Type: Rapid Fire Oral Abstract

Date: Tuesday, June 8, 2021

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:05pm-6:10pm

Location: Virtual

*Purpose: The purpose is to investigate the functional role of eosinophils during hepatic ischemia and reperfusion injury (IRI).

*Methods: Mice with antibody-induced eosinophil depletion and two strains of mice with genetic deletion of eosinophils were be used in the studies.

*Results: Unexpectedly, we identified a rapid accumulation of eosinophils in human liver grafts following hepatic transplantation. In contrast, no eosinophils were detectable in healthy liver tissues. Studies with genetic models of eosinophil deficiency or antibody-mediated eosinophil depletion revealed exacerbated injury following hepatic ischemia and reperfusion. Adoptive transfer of bone marrow-derived eosinophils normalized liver injury of eosinophil-deficient mice and reduced hepatic ischemia and reperfusion injury in wild-type mice. Mechanistic studies combining genetic and adoptive transfer approaches identified a critical role of suppression of tumorigenicity (ST2)-dependent production of interleukin-13 by eosinophils in the hepatoprotection against ischemia reperfusion-induced injury.

*Conclusions: Taken together, the present studies uncovered a previously unrecognized hepatoprotective function of eosinophils and implicated the IL-33/ST2-dependent IL-13 production in mediating the protective effect. The findings support further exploration of eosinophils and IL-33/ST2 signaling as candidate therapeutic targets to improve the outcomes of liver surgery and transplantation.

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To cite this abstract in AMA style:

Yang Y, Wang Y, Wang M, Jeong J, Xu L, Wen Y, Emontzpohl C, Dar W, Ju C. Eosinophils Attenuate Hepatic Ischemia Reperfusion Injury in Mice Through St2-Dependent Il-13 Production [abstract]. Am J Transplant. 2021; 21 (suppl 3). https://atcmeetingabstracts.com/abstract/eosinophils-attenuate-hepatic-ischemia-reperfusion-injury-in-mice-through-st2-dependent-il-13-production/. Accessed May 9, 2025.

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