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Articles tagged "Viral therapy"

  • 2022 American Transplant Congress

    A Randomized Phase 2 Study Of Mau868 Vs Placebo To Treat Bk Viremia In Kidney Transplant Recipients

    S. Jordan1, A. P. Limaye2, B. Fischbach3, P. Sood4, S. Collette5, L. Gasink6, M. W. Fordyce7, C. J. Lin7, M. Hodges6, D. C. Brennan8

    1Cedars-Sinai Medical Center, Los Angeles, CA, 2University of Washington, Seattle, WA, 3Dallas Nephrology Associates, Inc, Dallas, TX, 4University of Pittsburgh Medical Center, Pittsburgh, PA, 5Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada, 6previous employee/consultant for Amplyx Pharmaceuticals, San Diego, CA, 7Vera Therapeutics, Inc, Brisbane, CA, 8Johns Hopkins School of Medicine, Baltimore, MD

    *Purpose: To assess the safety and efficacy of MAU868, a BK virus-specific monoclonal antibody, in adult kidney transplant recipients with BK viremia.*Methods: This is a…
  • 2022 American Transplant Congress

    Risk for Loss of Hepatitis B Surface Antibody or Hepatitis B Reactivation in Kidney Transplant Recipients Receiving Lymphocyte Depleting Induction

    K. Paplaczyk1, C. Kane1, M. Kapugi1, K. Lang1, K. Cunningham1, C. D'Agostino1, J. Boike2

    1Pharmacy, Northwestern Memorial Hospital, Chicago, IL, 2Transplant Hepatology, Northwestern Memorial Hospital, Chicago, IL

    *Purpose: Although used in over 60% of kidney transplant recipients, the impact of lymphocyte depleting induction on hepatitis B surface antibody (HBsAb) and hepatitis B…
  • 2022 American Transplant Congress

    Clinical Features and Outcomes of Hospitalized Solid Organ Transplant and Hematopoietic Stem Cell Recipients with Sars-CoV-2 Infection in the Midwestern United States: A Multi-Center Retrospective Cohort Study

    S. Tanna1, D. Florescu2, A. Majeed3, J. Banzon3, S. Waller4, A. Eid4, N. Barros Baertl5, D. Friedman6, K. Mullane7, M. Ison8

    1Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 2University of Nebraska Medical Center, Omaha, NE, 3Cleveland Clinic, Cleveland, OH, 4University of Kansas Medical Center, Overland Park, KS, 5Infectious Diseases, Indiana University, Indianapolis, IN, 6Infectious Diseases, University of Chicago, Chicago, IL, 7University of Chicago, Chicago, IL, 8Northwestern University Comprehensive Transplant Center, Chicago, IL

    *Purpose: Immunocompromised hosts are at risk for severe complications or death from SARS-CoV-2 infection. Few studies describe the clinical features, outcomes and treatment strategies in…
  • 2022 American Transplant Congress

    Letermovir for Prophylaxis of Cytomegalovirus After Solid Organ Transplantation: A Single-Center, Observational Study

    T. N. Bullard1, C. A. Moore2, J. Dasigi2, L. M. Sacha2, C. A. Iasella3, K. A. Shimko2, E. K. McCreary4, F. P. Silveira4

    1Massachusetts General Hospital, Boston, MA, 2UPMC, Pittsburgh, PA, 3Univ of Pittsburgh, Pittsburgh, PA, 4Univ of Pittsburgh and UPMC, Pittsburgh, PA

    *Purpose: Cytomegalovirus (CMV) infections cause significant complications post-transplant; however, prophylactic medications are often limited by toxicities. Letermovir is a novel terminase inhibitor specific to CMV…
  • 2022 American Transplant Congress

    Post-Kidney Transplant Valacyclovir versus Valganciclovir for CMV Prophylaxis: A Randomized Controlled Trial

    P. S. Verghese1, A. Matas2, S. Chinnakotla2, M. Evans3, H. Balfour Jr4

    1Univ of Minnesota Pediatric Nephrology, Minneapolis, MN, 2Surgery, University of Minnesota Medical School, Minneapolis, MN, 3Biostatistics, University of Minnesota, Minneapolis, MN, 4Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN

    *Purpose: Valganciclovir (valG) is an effective CMV prophylactic agent post-kidney transplant (KTx) with significant side effects. Valacyclovir (valA) may be effective for CMV prophylaxis with…
  • 2022 American Transplant Congress

    Use of Viral Specific T Cell Therapy in Solid Organ Transplant Recipients – A Single Center Experience

    G. McGraw1, N. Patel2, K. Patel1, S. Bumb3, A. Govil4, M. Anand1

    1University of Cincinnati, Cincinnati, OH, 2Nephrology, University of Cincinnati, Cincinnati, OH, 3Nephrology, Internal Medicine, University of Cincinnati Medical Center, Blue Ash, OH, 4Univ of Cincinnati, Cincinnati, OH

    *Purpose: Viral infections such as BK virus (BKV), cytomegalovirus (CMV) and adenovirus after kidney transplantation negatively impact outcomes in solid organ transplant (SOT) recipients despite…
  • 2022 American Transplant Congress

    Impact of Glecaprevir/Pibrentasvir on Tacrolimus Concentration in Solid Organ Transplant Recipients with or without Triazole Antifungal Therapy

    D. Abraham1, A. Feist2, N. Law1, S. Aslam1, V. Nguyen1

    1University of California San Diego Health, San Diego, CA, 2University of California San Diego, San Diego, CA

    *Purpose: Provide guidance on tacrolimus (TAC) dose adjustments during glecaprevir/pibrentasvir (GLE/PIB) initiation and discontinuation in patients on triazole antifungals by comparing changes in TAC concentration-dose…
  • 2022 American Transplant Congress

    The Prevalence And Risk Factors Of De Novo Hepatitis B Virus Infection In Kidney Transplantation From Hepatitis B Antigen-positive Donors To Hbsag-negative Recipients

    J. Wu1, S. Yin1, F. Zhang1, L. Wu1, X. Wang2, T. Lin1

    1urology, west china hospital, Chengdu, China, 2Urology, West China Hospital, Chengdu, China

    *Purpose: To explore the prevalence and risk factors of de novo HBV infection (DNH) in kidney transplantation (KT) from HBsAg⁺ donors (D[HBsAg⁺]) to HBsAg-negative recipients…
  • 2022 American Transplant Congress

    Evaluation of the Management of Cytomegalovirus in Kidney Transplant Recipients After Establishment of a Multidisciplinary Cytomegalovirus Workgroup

    A. Boyle, A. Spenningsby, H. Rhodes, T. Anderson-Haag

    Hennepin County Medical Center, Minneapolis, MN

    *Purpose: To assess the effectiveness of a multidisciplinary cytomegalovirus (CMV) workgroup in managing CMV in kidney transplant recipients.*Methods: Retrospective chart review at a single transplant…
  • 2022 American Transplant Congress

    Ultra-Short Duration Prophylaxis for Hepatitis C Donor Positive to Recipient Negative Simultaneous Kidney/Pancreas Transplants

    G. Gupta, I. Yakubu, A. Khan, R. Sterling

    Virginia Commonwealth University, Richmond, VA

    *Purpose: Recent trials have successfully utilized a strategy of hepatitis C virus (HCV) D+ [Donor nucleic acid test (NAT) positive]/R- (Recipient NAT negative) kidney and/or…
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